Article
Immunology
Zhujun Jiang, Haishuang Lin, Haoran Zhang, Ningning Shi, Zhetao Zheng, Liangzhen Dong, Yuelin Yang, Qing Xia
Summary: By analyzing peripheral blood cells from CoronaVac-vaccinated individuals and COVID-19 recovered patients, researchers found that the vaccine can significantly increase SARS-CoV-2 neutralizing antibody levels and induce changes in immune cell responses. After vaccination, type-1 helper T cells (Th1) and antibodies dominate humoral immune responses, while T follicular helper cells (Tfh) are involved in antibody production. Additionally, multi-omics analysis of vaccinated and recovered individuals identified specific changes in serum proteins, metabolites, and lipids. These findings provide a comprehensive understanding of the in vitro immune features specific to CoronaVac.
Article
Immunology
Qiu-Yan Xu, Jian-Hang Xue, Yao Xiao, Zhi-Juan Jia, Meng-Juan Wu, Yan-Yun Liu, Wei-Li Li, Xian-Ming Liang, Tian-Ci Yang
Summary: An urgent need for a highly protective vaccine against COVID-19 exists. This study evaluated the response and duration of 5 subsets of anti-SARS-CoV-2 antibodies post-vaccination, and found intense but decaying antibody response with the CoronaVac vaccine, suggesting the need for booster doses in vaccine strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Gabriele Anichini, Chiara Terrosi, Gianni Gori Savellini, Claudia Gandolfo, Federico Franchi, Maria Grazia Cusi
Summary: The study found that healthy individuals vaccinated with the Comirnaty vaccine had significantly lower neutralizing antibody titers against the B.1.351 lineage, suggesting potential differences in protection levels among different SARS-CoV-2 lineages. No significant differences in neutralizing antibody titers were observed for the other two lineages.
Article
Nutrition & Dietetics
Yao Deng, Liting Huang, Peixin Liu, Xuyang Geng, Zefang Lin, Zhixiong Zheng, Meixiao Zhan, Zhiren Zhang, Junwei Liu, Taoping Sun
Summary: The third dose of the SARS-CoV-2 vaccine significantly improves the body's ability to fight against the virus. Higher levels of vitamin D are associated with decreased levels of virus-neutralizing antibodies and lower seropositive rates for the omicron variant after vaccination. Further studies with larger patient cohorts of different nutritional statuses are needed to confirm these results.
FRONTIERS IN NUTRITION
(2023)
Article
Immunology
Yufei Wu, Ping Huang, Mingjie Xu, Qianqian Zhao, Yihui Xu, Shuyi Han, Huanjie Li, Yunshan Wang
Summary: Monitoring the dynamic change in neutralizing antibodies is necessary after COVID-19 vaccination. The rate of reduction of SARS-CoV-2 neutralizing antibody levels gradually showed after booster doses. CD25+T cell expression was significantly higher in the 18-35 age group. Booster vaccination in older adults and regular testing of neutralizing antibodies are recommended if the antibody level falls below 30% inhibition rate.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ping Li, Dawei Shi, Wenlong Shen, Shu Shi, Xinjie Guo, Jia Li, Sihong Xu, Yan Zhang, Zhihu Zhao
Summary: This study conducted a genome-wide association study in recipients of SARS-CoV-2 vaccines, identifying 177 SNPs and 41 independent loci associated with antibody levels. Specifically, the intronic variant rs4543780 of the FAM89A gene was found to be associated with total antibody levels and potentially affecting gene expression, with FAM89A being a biomarker for differentiating bacterial and viral infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Xin-Qi Zheng, Qiu-Yan Xu, Lin Xie, Yun He, Yong-Jing Wang, Li-Li Liu, Li-Rong Lin, Tian-Ci Yang
Summary: A cohort study was conducted to evaluate the response and duration of antibodies induced by a novel coronavirus-inactivated vaccine one year after the third dose. The levels of neutralizing, total, and IgG antibodies were assessed, and their kinetics and attenuation were evaluated. The results showed that these antibodies provided protection from infection and severe infection, with higher levels observed in younger individuals. The half-lives of the antibodies ranged from 186.89 to 417.50 days.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sikang Gao, Na Ren, Taoping Sun, Qi Nie, Sitian Liu, Xuyang Geng, Yao Deng, Zefang Lin, Yu Liu, Li Zhou
Summary: Higher plasma selenium and selenoprotein P were associated with increased neutralizing antibody response before the third dose of inactivated SARS-CoV-2 vaccine, but not after the third dose.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Immunology
Li-Na Yan, Zhong-Xin Zhao, Zhen-Dong Wang, Xiao Xiao, Pan-Pan Liu, Wen-Kang Zhang, Xiao-Lan Gu, Bang Li, Li-Ping Yu, Xue-Jie Yu
Summary: A study found that the majority of individuals who received two doses of the Chinese inactivated SARS-CoV-2 vaccine developed strong neutralizing antibodies and T-cell immune responses in the first two months after the second dose. However, after six months, only 37.0% and 44.0% of vaccinees retained neutralizing antibodies and T-cell immunity to SARS-CoV-2, respectively. Additionally, the study found that the neutralizing potency of immune serum decreased significantly against certain variants.
EXPERT REVIEW OF VACCINES
(2022)
Article
Immunology
Sarinya Boongird, Chavachol Setthaudom, Rungthiwa Kitpermkiat, Somsak Prasongtanakij, Supanart Srisala, Piyatida Chuengsaman, Arkom Nongnuch, Montira Assanatham, Sasisopin Kiertiburanakul, Kumthorn Malathum, Angsana Phuphuakrat, Jackrapong Bruminhent
Summary: This study assessed the changes in humoral and cell-mediated immunity in dialysis patients 6 months after receiving the COVID-19 vaccine. The results showed a significant decline in humoral immunity, while cell-mediated immunity remained stable. The study suggests considering a booster dose for dialysis patients 3 months after the initial vaccination.
Article
Medicine, General & Internal
Hong-Xing Pan, Jian-Kai Liu, Bao-Ying Huang, Gui-Fan Li, Xian-Yun Chang, Ya-Fei Liu, Wen-Ling Wang, Kai Chu, Jia-Lei Hu, Jing-Xin Li, Dan-Dan Zhu, Jing-Liang Wu, Xiao-Yu Xu, Li Zhang, Meng Wang, Wen-Jie Tan, Wei-Jin Huang, Feng-Cai Zhu
Summary: This study reported the immunogenicity and safety of an inactivated SARS-CoV-2 vaccine, KCONVAC, in healthy adults. The vaccine demonstrated good tolerability and induced robust immune responses in both phase 1 and phase 2 trials.
CHINESE MEDICAL JOURNAL
(2021)
Article
Immunology
Jing Li, Jingjing Li, Shuzhi Dai, Li Dang, Lin Wang, Ling Cao, Xiaobo Chen, Ying Wang, Menglei Ge, Weijie Liu, Qinwei Song, Wenjian Xu, Lijuan Ma
Summary: Objective analysis of SARS-CoV-2 IgG antibody and neutralizing antibody levels in children aged 3-11 years, comparing vaccinated and unvaccinated individuals, provides evidence for formulating vaccination strategies and control policies.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Immunology
Yun Liao, Ying Zhang, Heng Zhao, Jing Pu, Zhimei Zhao, Dandan Li, Shengtao Fan, Li Yu, Xingli Xu, Lichun Wang, Guorun Jiang, Longding Liu, Qihan Li
Summary: A study on individuals who received an inactivated SARS-CoV-2 vaccine showed a decrease in neutralizing antibodies over time, but the waning of antibodies does not necessarily indicate a loss of immunity.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Infectious Diseases
Roberta Rizzo, Daria Bortolotti, Luca Morandi, Sabrina Rizzo, Giovanna Schiuma, Silvia Beltrami, Alberto Papi, Marco Contoli
Summary: This study reports the relevance of serum antibody levels and the immune response to SARS-CoV-2 vaccines. The findings show that booster dose induces enhanced humoral and adaptive immune responses and early activation of memory CD8+ T subset.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Sicong Yu, Keda Che, Lei Fang, Haiyan Mao, Xiuyu Lou, Chaonan Li, Yanjun Zhang
Summary: SARS-CoV-2, MERS-CoV, and SARS-CoV pose a great threat to humanity, and the development of vaccines is crucial in combating these coronaviruses. Different types of vaccines are being researched and developed, with studies on neutralizing antibodies helping to evaluate and analyze the effectiveness of the vaccines.