REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion

Homeostatic Plasticity in Epilepsy

(2020) Gabriele Lignani et al.   Frontiers in Cellular Neuroscience

Spike-Related Electrophysiological Identification of Cultured Hippocampal Excitatory and Inhibitory Neurons

(2019) Cosimo Prestigio et al.   MOLECULAR NEUROBIOLOGY

Regulation of lifespan by neural excitation and REST

(2019) Joseph M. Zullo et al.   NATURE

Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal Neurons

(2018) Pierluigi Valente et al.   CEREBRAL CORTEX

Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease

(2018) Boaz Styr et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse

(2018) Samuel Frere et al.   NEURON

REST-Dependent Presynaptic Homeostasis Induced by Chronic Neuronal Hyperactivity

(2017) F. Pecoraro-Bisogni et al.   MOLECULAR NEUROBIOLOGY

Models of drug-induced epileptiform synchronization in vitro

(2016) Massimo Avoli et al.   JOURNAL OF NEUROSCIENCE METHODS

Npas4: Linking Neuronal Activity to Memory

(2016) Xiaochen Sun et al.   TRENDS IN NEUROSCIENCES

Fine Tuning of Synaptic Plasticity and Filtering by GABA Released from Hippocampal Autaptic Granule Cells

(2015) Pierluigi Valente et al.   CEREBRAL CORTEX

Regulation of neural gene transcription by optogenetic inhibition of the RE1-silencing transcription factor

(2015) Francesco Paonessa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

(2015) Arshan Perera et al.   Cell Reports

Interplay between population firing stability and single neuron dynamics in hippocampal networks

(2015) Edden Slomowitz et al.   eLife

Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs

(2014) Ivo Spiegel et al.   CELL

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons

(2014) Thomas Andreska et al.   Frontiers in Cellular Neuroscience

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

(2014) Shawn McClelland et al.   eLife

Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs

(2013) David C. Bersten et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

(2013) Davide Pozzi et al.   EMBO JOURNAL

The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition

(2013) Brenda L. Bloodgood et al.   NATURE

Involvement of TrkB- and p75NTR-signaling pathways in two contrasting forms of long-lasting synaptic plasticity

(2013) Shigeo Sakuragi et al.   Scientific Reports

Specificity Protein 1 (Sp1)-dependent Activation of the Synapsin I Gene (SYN1) Is Modulated by RE1-silencing Transcription Factor (REST) and 5′-Cytosine-Phosphoguanine (CpG) Methylation

(2012) Francesco Paonessa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons

(2012) Sandra Dieni et al.   JOURNAL OF CELL BIOLOGY

Distinct Subsets of Syt-IV/BDNF Vesicles Are Sorted to Axons versus Dendrites and Recruited to Synapses by Activity

(2012) C. Dean et al.   JOURNAL OF NEUROSCIENCE

Site-Specific Synapsin I Phosphorylation Participates in the Expression of Post-Tetanic Potentiation and Its Enhancement by BDNF

(2012) P. Valente et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Regulation of Inhibition via GAD67

(2012) C. G. Lau et al.   JOURNAL OF NEUROSCIENCE

Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex

(2012) Gerard M J Beaudoin et al.   Nature Protocols

Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

(2011) Shawn McClelland et al.   ANNALS OF NEUROLOGY

Conditional Deletion of NRSF in Forebrain Neurons Accelerates Epileptogenesis in the Kindling Model

(2011) Xiao-Ling Hu et al.   CEREBRAL CORTEX

Identification of cis-Elements and Transcription Factors Regulating Neuronal Activity-Dependent Transcription of Human BDNF Gene

(2011) P. Pruunsild et al.   JOURNAL OF NEUROSCIENCE

A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo

(2011) Y. Jiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain-derived neurotrophic factor and the development of structural neuronal connectivity

(2010) Susana Cohen-Cory et al.   Developmental Neurobiology

Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington’s disease

(2010) Chiara Soldati et al.   JOURNAL OF NEUROCHEMISTRY

Blood gene expression correlated with tic severity in medicated and unmedicated patients with Tourette Syndrome

(2010) Isaac H Liao et al.   PHARMACOGENOMICS

Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF

(2009) Daichi Hara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GABAB Receptor Activation Triggers BDNF Release and Promotes the Maturation of GABAergic Synapses

(2009) H. Fiorentino et al.   JOURNAL OF NEUROSCIENCE

Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release

(2009) Camin Dean et al.   NATURE NEUROSCIENCE

The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses

(2008) Gina G. Turrigiano   CELL

Huntingtin Regulates RE1-silencing Transcription Factor/Neuron-restrictive Silencer Factor (REST/NRSF) Nuclear Trafficking Indirectly through a Complex with REST/NRSF-interacting LIM Domain Protein (RILP) and Dynactin p150Glued

(2008) Masahito Shimojo   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

(2008) Tomoya Matsumoto et al.   NATURE NEUROSCIENCE