Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

Pharmacological inhibition of the mitochondrial Ca2+ uniporter: Relevance for pathophysiology and human therapy

(2020) Katalin Márta et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

(2019) Vikram Jakkamsetti et al.   Science Translational Medicine

Loss of MPC1 reprograms retinal metabolism to impair visual function

(2019) Allison Grenell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

M-channel activation contributes to the anticonvulsant action of the ketone body β-hydroxybutyrate

(2019) Rian W Manville et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

KCNQ-Encoded Potassium Channels as Therapeutic Targets

(2018) Vincenzo Barrese et al.   Annual Review of Pharmacology and Toxicology

The anti-epileptogenic and cognition enhancing effect of novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea (BPPU) in pentylenetetrazole induced chronic rat model of epilepsy

(2018) Chandra Bhushan Mishra et al.   BIOMEDICINE & PHARMACOTHERAPY

Electrophysiological Evidence for the Development of a Self-Sustained Large-Scale Epileptic Network in the Kainate Mouse Model of Temporal Lobe Epilepsy

(2018) Laurent Sheybani et al.   JOURNAL OF NEUROSCIENCE

Ketogenic Diet Therapy in Infants: Efficacy and Tolerability

(2018) Elaine Wirrell et al.   PEDIATRIC NEUROLOGY

Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia

(2018) Thomas Marissal et al.   NATURE NEUROSCIENCE

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

(2017) Ajit S. Divakaruni et al.   JOURNAL OF CELL BIOLOGY

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Modulation of Kv7 channels and excitability in the brain

(2016) Derek L. Greene et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α

(2016) Anna Tosatto et al.   EMBO Molecular Medicine

Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum

(2016) M.I. Cordero et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus

(2016) Elias Gebara et al.   STEM CELLS

Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet

(2016) Benoît Vanderperre et al.   PLoS Genetics

Regulation of Postsynaptic Function by the Dementia-Related ESCRT-III Subunit CHMP2B

(2015) R. Chassefeyre et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

(2014) Patrick A. Vigueira et al.   Cell Reports

Distribution of CaMKIIα expression in the brain in vivo, studied by CaMKIIα-GFP mice

(2013) Xinjun Wang et al.   BRAIN RESEARCH

Inhibition of Mitochondrial Pyruvate Transport by Zaprinast Causes Massive Accumulation of Aspartate at the Expense of Glutamate in the Retina

(2013) Jianhai Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

(2013) Peter Schönfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons

(2013) Andres De la Rossa et al.   NATURE NEUROSCIENCE

Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes

(2013) Massimo Bonora et al.   Nature Protocols

A Change in Configuration of the Calmodulin-KCNQ Channel Complex Underlies Ca2+-Dependent Modulation of KCNQ Channel Activity

(2013) Anastasia Kosenko et al.   PLoS One

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

(2013) A. S. Divakaruni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

(2013) Jing Qiu et al.   Nature Communications

BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures

(2012) Alfredo Giménez-Cassina et al.   NEURON

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Mitochondrial calcium homeostasis as potential target for mitochondrial medicine

(2011) Carlotta Giorgi et al.   MITOCHONDRION

Mitochondrial disorders caused by mutations in respiratory chain assembly factors

(2011) Francisca Diaz et al.   Seminars in Fetal & Neonatal Medicine

Four novel PDHA1 mutations in pyruvate dehydrogenase deficiency

(2009) E. Ostergaard et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Ketone bodies, glycolysis, and KATPchannels in the mechanism of the ketogenic diet

(2008) Gary Yellen   EPILEPSIA

SK (KCa2) Channels Do Not Control Somatic Excitability in CA1 Pyramidal Neurons But Can Be Activated by Dendritic Excitatory Synapses and Regulate Their Impact

(2008) Ning Gu et al.   JOURNAL OF NEUROPHYSIOLOGY

Mouse models of humanKCNQ2andKCNQ3mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization

(2008) Nanda A. Singh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Plasticity of intrinsic neuronal properties in CNS disorders

(2008) Heinz Beck et al.   NATURE REVIEWS NEUROSCIENCE

A mouse model for studying large-scale neuronal networks using EEG mapping techniques

(2008) Pierre Mégevand et al.   NEUROIMAGE