Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease

(2020) Juliette Le Douce et al.   Cell Metabolism

Glucose metabolism links astroglial mitochondria to cannabinoid effects

(2020) Daniel Jimenez-Blasco et al.   NATURE

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

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The lactate receptor HCAR1 modulates neuronal network activity through the activation of Gα and Gβɣ subunits

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Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor

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Optogenetic assessment of VIP, PV, SOM and NOS inhibitory neuron activity and cerebral blood flow regulation in mouse somato-sensory cortex

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Ultrastructural Evidence for a Role of Astrocytes and Glycogen-Derived Lactate in Learning-Dependent Synaptic Stabilization

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Cryo-electron microscopy structures and progress toward a dynamic understanding of KATPchannels

(2018) Michael C. Puljung   JOURNAL OF GENERAL PHYSIOLOGY

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Supragranular Pyramidal Cells Exhibit Early Metabolic Alterations in the 3xTg-AD Mouse Model of Alzheimer’s Disease

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Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

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Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

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A molecular atlas of cell types and zonation in the brain vasculature

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Molecular and functional characterization of the endothelial ATP-sensitive potassium channel

(2017) Qadeer Aziz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular structure of human KATP in complex with ATP and ADP

(2017) Kenneth Pak Kin Lee et al.   eLife

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

(2017) Gregory M Martin et al.   eLife

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Peripheral administration of lactate produces antidepressant-like effects

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Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

(2016) Bosiljka Tasic et al.   NATURE NEUROSCIENCE

Cell type specificity of neurovascular coupling in cerebral cortex

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ATP-sensitive potassium channels: uncovering novel targets for treating depression

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Hemichannel-mediated release of lactate

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COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex

(2015) A. Lacroix et al.   JOURNAL OF NEUROSCIENCE

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

(2015) T. Sotelo-Hitschfeld et al.   JOURNAL OF NEUROSCIENCE

Glucose Induces Slow-Wave Sleep by Exciting the Sleep-Promoting Neurons in the Ventrolateral Preoptic Nucleus: A New Link between Sleep and Metabolism

(2015) C. Varin et al.   JOURNAL OF NEUROSCIENCE

NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting

(2015) Rodrigo Lerchundi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting LDH enzymes with a stiripentol analog to treat epilepsy

(2015) N. Sada et al.   SCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

(2015) Iben Lundgaard et al.   Nature Communications

Highly Energized Inhibitory Interneurons are a Central Element for Information Processing in Cortical Networks

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GABAergic Neurogliaform Cells Represent Local Sources of Insulin in the Cerebral Cortex

(2014) G. Molnar et al.   JOURNAL OF NEUROSCIENCE

KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons

(2014) Maria S. Lemak et al.   Frontiers in Cellular Neuroscience

Energy substrates that fuel fast neuronal network oscillations

(2014) Lukas V. Galow et al.   Frontiers in Neuroscience

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

Glucose-stimulated Single Pancreatic Islets Sustain Increased Cytosolic ATP Levels during Initial Ca2+Influx and Subsequent Ca2+Oscillations

(2013) Takashi Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycolysis and Oxidative Phosphorylation in Neurons and Astrocytes during Network Activity in Hippocampal Slices

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Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway

(2013) Luigi Bozzo et al.   PLoS One

Molecular and functional characterization of GAD67-expressing, newborn granule cells in mouse dentate gyrus

(2013) Carolina Cabezas et al.   Frontiers in Neural Circuits

Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio

(2013) Mathew Tantama et al.   Nature Communications

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase

(2012) Hyun B. Choi et al.   NEURON

BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures

(2012) Alfredo Giménez-Cassina et al.   NEURON

Characterization of Type I and Type II nNOS-Expressing Interneurons in the Barrel Cortex of Mouse

(2012) Quentin Perrenoud et al.   Frontiers in Neural Circuits

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Single KATP Channel Opening in Response to Action Potential Firing in Mouse Dentate Granule Neurons

(2011) G. R. Tanner et al.   JOURNAL OF NEUROSCIENCE

NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K+

(2011) I. Ruminot et al.   JOURNAL OF NEUROSCIENCE

In Vivo Evidence for Lactate as a Neuronal Energy Source

(2011) M. T. Wyss et al.   JOURNAL OF NEUROSCIENCE

miR-29a and miR-29b Contribute to Pancreatic  -Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)

(2011) T. J. Pullen et al.   MOLECULAR AND CELLULAR BIOLOGY

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

(2010) Kashan Ahmed et al.   Cell Metabolism

M3 Muscarinic Acetylcholine Receptor Expression Confers Differential Cholinergic Modulation to Neurochemically Distinct Hippocampal Basket Cell Subtypes

(2010) C. A. Cea-del Rio et al.   JOURNAL OF NEUROSCIENCE

Metabolic Autocrine Regulation of Neurons Involves Cooperation among Pannexin Hemichannels, Adenosine Receptors, and KATP Channels

(2010) M. Kawamura et al.   JOURNAL OF NEUROSCIENCE

Predominant Enhancement of Glucose Uptake in Astrocytes versus Neurons during Activation of the Somatosensory Cortex

(2010) J. Chuquet et al.   JOURNAL OF NEUROSCIENCE

Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction

(2010) Hélène Girouard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal activity in vitro and the in vivo reality: the role of energy homeostasis

(2010) Yuri Zilberter et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pinacidil induces vascular dilation and hyperemia in vivo and does not impact biophysical properties of neurons and astrocytes in vitro

(2009) R. CAO et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Stimulus-Induced Changes in Blood Flow and 2-Deoxyglucose Uptake Dissociate in Ipsilateral Somatosensory Cortex

(2009) A. Devor et al.   JOURNAL OF NEUROSCIENCE

Classification of NPY-Expressing Neocortical Interneurons

(2009) A. Karagiannis et al.   JOURNAL OF NEUROSCIENCE

Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

(2009) H. Imamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types

(2008) Joseph P. Doyle et al.   CELL

Lactate fuels the human brain during exercise

(2008) Bjørn Quistorff et al.   FASEB JOURNAL

Gap Junction-Mediated Astrocytic Networks in the Mouse Barrel Cortex

(2008) V. Houades et al.   JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

What we can do and what we cannot do with fMRI

(2008) Nikos K. Logothetis   NATURE

Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex

(2008)   NATURE REVIEWS NEUROSCIENCE

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE