Article
Cell Biology
Kenneth J. O'Riordan, Michael K. Collins, Gerard M. Moloney, Emily G. Knox, Maria R. Aburto, Christine Fulling, Shane J. Morley, Gerard Clarke, Harriet Schellekens, John F. Cryan
Summary: The role of the intestinal microbiota in regulating gut-brain axis signaling has gained attention in recent years. Understanding the relationship between the gut microbiota, its metabolites, and the brain is crucial for developing new therapeutic approaches, including identifying psychobiotics. Current research focuses on the effects of short-chain fatty acids (SCFAs), such as butyrate, acetate, and propionate, on brain function, behavior, and physiology, and how these SCFAs enter the systemic circulation and can potentially impact the brain.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Microbiology
Weiping Xiao, Jiabin Su, Xinjie Gao, Heng Yang, Ruiyuan Weng, Wei Ni, Yuxiang Gu
Summary: This study demonstrates that modulating the gut microbiome via fecal microbiota transplantation (FMT) can improve cognitive impairment and depressive-like behaviors caused by chronic cerebral hypoperfusion. FMT increases the level of short-chain fatty acids (SCFAs), promotes gut function, and improves cognitive performance. Long-term SCFA supplementation also reduces inflammation and hippocampal neuronal apoptosis.
Review
Food Science & Technology
Bingbing Guo, Jingyi Zhang, Weihao Zhang, Feng Chen, Bin Liu
Summary: This comprehensive review explores the production of short chain fatty acids (SCFAs) by gut microbiota, their transportation through the gut-brain axis, and the potential mechanisms by which they influence age-related neurodegenerative disorders. The review also discusses the importance of dietary fiber sources and the challenges associated with harnessing dietary-derived SCFAs as promoters of neurological health in elderly individuals.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Atreye Majumdar, Indira Priya Siva Venkatesh, Anirban Basu
Summary: The gut-brain axis refers to the communication between the brain and gastrointestinal tract, and the role of gut microbiome and short-chain fatty acids in neurodegenerative diseases and neuroinflammation.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Katarzyna Socala, Urszula Doboszewska, Aleksandra Szopa, Anna Serefko, Marcin Wlodarczyk, Anna Zielinska, Ewa Poleszak, Jakub Fichna, Piotr Wlaz
Summary: Emerging evidence suggests that gut microbiota play a crucial role in the bidirectional communication between the gut and brain, influencing neural development, neurotransmission, and behavior. Studies have explored the role of microbiota in various neuropsychiatric and neurological disorders, including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, and epilepsy. This review discusses data from both preclinical experiments and clinical reports, highlighting the effects of probiotic, prebiotic, or antibiotic treatments, as well as fecal microbiota transplantation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biology
Zhao-Bo Luo, Shengzhong Han, Xi-Jun Yin, Hongye Liu, Junxia Wang, Meifu Xuan, Chunyun Hao, Danqi Wang, Yize Liu, Shuangyan Chang, Dongxu Li, Kai Gao, Huiling Li, Biaohu Quan, Lin-Hu Quan, Jin-Dan Kang
Summary: The host genome and intestinal microbiota have mutual influences on each other. Deletion of the myostatin (MSTN) gene in pigs positively regulates the expression of tight junction-related genes in the intestine, leading to changes in the structure of the intestinal microbiota. Transplantation of the intestinal microbiota from MSTN-deficient pigs into mice resulted in increased muscle growth and higher levels of short-chain fatty acids.
Review
Biochemistry & Molecular Biology
Sumel Ashique, Gabriele De Rubis, Ekta Sirohi, Neeraj Mishra, Mohd Rihan, Ashish Garg, Ruby-Jean Reyes, Bikash Manandhar, Shvetank Bhatt, Niraj Kumar Jha, Thakur Gurjeet Singh, Gaurav Gupta, Sachin Kumar Singh, Dinesh Kumar Chellappan, Keshav Raj Paudel, Philip M. Hansbro, Brian G. Oliver, Kamal Dua
Summary: The human microbiota plays a crucial role in immune system development and balance. Dysbiosis in the gut and respiratory tract is associated with immune system dysfunction and the development of lung diseases. Short-chain fatty acids (SCFAs) produced by the gut microbiota have a significant impact on the homeostasis, susceptibility, and outcome of various lung diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Plant Sciences
Hui-Hui Guo, Hao-Ran Shen, Ming-Ze Tang, Ning Sheng, Xiao Ding, Yuan Lin, Jin-Lan Zhang, Jian-Dong Jiang, Tian-Le Gao, Lu-Lu Wang, Yan-Xing Han
Summary: This study revealed that the Dengzhan shengmai (DZSM) formula improves cerebral ischemic diseases by regulating the gut microbiota and their production of short-chain fatty acids (SCFAs). DZSM treatment altered the gut microbiota composition and enhanced SCFA production, leading to the inhibition of neurocyte apoptosis and the improvement of cerebral neuropathy and oxidative stress. Additionally, DZSM repaired gut barrier integrity, reduced endotoxin translocation, and attenuated neuro-inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zhengjian Wang, Jin Liu, Fan Li, Yalan Luo, Peng Ge, Yibo Zhang, Haiyun Wen, Qi Yang, Shurong Ma, Hailong Chen
Summary: This review discusses the role of gut microbiota in regulating intestinal homeostasis and the pathogenesis of severe acute pancreatitis-associated lung injury (PALI). It focuses on the involvement of short-chain fatty acids (SCFAs) in PALI and summarizes potential therapeutic interventions targeting SCFAs.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Peng Zhao, Suhong Zhao, Jinwei Tian, Xinxin Liu
Summary: This review primarily focuses on the relationship between the gut microbiota and its major metabolites, such as short-chain fatty acids (SCFAs), and heart failure (HF), aiming to explore effective treatments for HF by targeting SCFAs and improve patients' quality of life.
Review
Nutrition & Dietetics
Songhyun Ju, Yoonhwa Shin, Sunhee Han, Juhui Kwon, Tae Gyu Choi, Insug Kang, Sung Soo Kim
Summary: Schizophrenia, a severe mental illness affecting about 1% of the population, is influenced by multiple factors including genetics, adversity, infection, and gene-environment interactions. Recent research suggests that maternal infection or stress during pregnancy may increase the risk of schizophrenia in offspring. The gut-brain axis, specifically the gut microbiome, has been found to play a significant role in CNS function and mental health, including schizophrenia.
Review
Geriatrics & Gerontology
Xiao-hang Qian, Ru-yan Xie, Xiao-li Liu, Sheng-di Chen, Hui-dong Tang
Summary: Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber. They play a role in various physiological and pathological processes in the human body, including potential roles and mechanisms in neurodegenerative diseases such as Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Ezgi Tas, Kutlu O. Ulgen
Summary: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by hyperactivity, impulsivity, and a lack of attention inconsistent with the patient's development level. The presence of certain gut microbiota, such as Coprococcus, Collinsella, Bacteroides, and Alistipes, may serve as indicators of ADHD. A modeling approach that considers the interactions between microbial genome and environment helps us understand the gastrointestinal mechanisms behind ADHD and potentially improve the quality of life for ADHD patients.
Article
Gastroenterology & Hepatology
Thomas Henry Tranah, Lindsey A. Edwards, Bernd Schnabl, Debbie Lindsay Shawcross
Summary: Cirrhotic portal hypertension is characterized by the development of serious complications such as ascites, encephalopathy, bleeding, and hepatorenal syndrome, which are often caused by cirrhosis-associated immune dysfunction. Bacterial infections are common complications of chronic liver disease and are closely linked to dysbiosis of the intestinal microbiota.
Article
Immunology
Xiran Lou, Jinfang Xue, Ruifei Shao, Yan Yang, Deyuan Ning, Chunyan Mo, Fuping Wang, Guobing Chen
Summary: This study found significant differences in gut microbiota between sepsis patients and healthy individuals. Fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) were found to regulate the abundance of bacteria and improve survival rate and systemic inflammatory response in a mouse model of sepsis. These findings suggest that FMT and SCFAs may be a potential treatment for sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Michal Bialy, Wiktor Bogacki-Rychlik, Kaja Kasarello, Evgeni Nikolaev, Elzbieta M. Sajdel-Sulkowska
BEHAVIORAL NEUROSCIENCE
(2016)
Article
Neurosciences
Z. L. Sulkowski, T. Chen, S. Midha, A. M. Zavacki, Elizabeth M. Sajdel-Sulkowska
Article
Neurosciences
Ming Xu, Elizabeth M. Sajdel-Sulkowska, Toshiharu Iwasaki, Noriyuki Koibuchi
Article
Neurosciences
M. Xu, Z. L. Sulkowski, P. Parekh, A. Khan, T. Chen, S. Midha, T. Iwasaki, N. Shimokawa, N. Koibuchi, A. M. Zavacki, E. M. Sajdel-Sulkowska
Review
Neurosciences
Elzbieta M. Sajdel-Sulkowska, Monika Makowska-Zubrycka, Katarzyna Czarzasta, Kaja Kasarello, Vishal Aggarwal, Michal Bialy, Ewa Szczepanska-Sadowska, Agnieszka Cudnoch-Jedrzejewska
Article
Endocrinology & Metabolism
Ming Xu, Toshiharu Iwasaki, Noriaki Shimokawal, Elizabeth M. Sajdel-Sukowska, Noriyuki Koibuchi
Article
Psychology, Biological
Katarzyna Czarzasta, Monika Makowska-Zubrycka, Kaja Kasarello, Veronica M. Skital, Karolina Tyszkowska, Katarzyna Matusik, Anika Jesion, Malgorzata Wojciechowska, Agnieszka Segiet, Robert Wrzesien, Michal Bialy, Pawel Krzascik, Aleksandra Wislowska-Stanek, Elzbieta M. Sajdel-Sulkowska
PHYSIOLOGY & BEHAVIOR
(2019)
Review
Cell Biology
Tingting Hu, Yinmiao Dong, Caixia He, Mingyi Zhao, Qingnan He
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Behavioral Sciences
Katarzyna Czarzasta, Malgorzata Wojciechowska, Agnieszka Segiet-Swiecicka, Sonia Borodzicz-Jazdzyk, Magdalena Niedziela, Elizabeth M. Sajdel-Sulkowska
Summary: Maternal depression during pregnancy has been found to impact offspring cardiovascular function, specifically impairing diastolic cardiac functions in the left ventricle.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Medicine, General & Internal
Agnieszka Wsol, Agata Gondek, Martyna Podobinska, Marek Chmielewski, Elzbieta Sajdel-Sulkowska, Agnieszka Cudnoch-Jedrzejewska
Summary: This study found that the presence of arterial hypertension is associated with increased activity of the oxytocinergic system in the heart, especially in the area of the left ventricle. These findings support the important role of this system in the maintenance of cardiovascular homeostasis.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Neurosciences
Michal Bialy, Martyna Podobinska, Jaroslaw Barski, Wiktor Bogacki-Rychlik, Elzbieta M. Sajdel-Sulkowska
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2019)
Article
Physiology
A. Khan, J. W. Harney, A. M. Zavackp, E. M. Sajdel-Sulkowskal
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2014)
Meeting Abstract
Biochemistry & Molecular Biology
M. Xu, T. Iwasaki, E. M. Sajdel-Sulkowska, N. Shimokawa, N. Koibuchi
JOURNAL OF NEUROCHEMISTRY
(2012)
Article
Physiology
A. Khan, Z. L. Sulkowski, T. Chen, A. M. Zavacki, E. M. Sajdel-Sulkowska
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2012)