Article
Engineering, Biomedical
Cong Zhang, Qingrong Li, Jie Shan, Jianghao Xing, Xiaoyan Liu, Yan Ma, Haisheng Qian, Xulin Chen, Xianwen Wang, Lian-Ming Wu, Yue Yu
Summary: The overexpression of reactive oxygen and nitrogen species (RONS) in the colonic mucosa destroys the mucosa and its barrier, accelerating the occurrence of inflammatory bowel disease (IBD). The elimination of RONS from the inflammatory colon has proven effective in alleviating IBD. Bi2Se3 nanodiscs modified with PVP were developed as a multifunctional nanozyme for the treatment of IBD. The nanodiscs can eliminate multiple RONS, enhance cellular survival, alleviate intestinal inflammation, and regulate intestinal flora.
ACTA BIOMATERIALIA
(2023)
Article
Nanoscience & Nanotechnology
Weicai Wang, Youcheng Yang, Xiaozu Chen, Tingting Zhao, Xuemei Li
Summary: A biodegradable self-supplying cascade reactor with hollow mesoporous manganese dioxide nanospheres as carriers was developed, which improved the hypoxia characteristics of the tumor microenvironment for synergistic starvation therapy and chemiexcited PDT. The cascade nanoreactor released drugs, produced oxygen, and stimulated the activation of the photosensitizer to induce cancer cell death, offering a promising approach for cancer therapy.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hao Xiong, Yongzheng Zhao, Qinyuan Xu, Xue Xie, Jianrong Wu, Bing Hu, Shuai Chen, Xiaojun Cai, Yuanyi Zheng, Cunyi Fan
Summary: Nanozymes are widely used for treating major diseases, and this study introduces a pH-responsive biodegradable nanozyme for the treatment of osteoarthritis. The nanozyme shows good biodegradability, biocompatibility, and multi-enzyme activities, and it effectively inhibits oxidative damage and suppresses inflammation.
Article
Chemistry, Multidisciplinary
Jingqi Li, Xinda Cai, Yihan Zhang, Kangning Li, Lingyun Guan, Yilong Li, Ting Wang, Tiedong Sun
Summary: In this study, PVP/MnO2-Ti3C2 composites with dual enzymatic activities and PTT effect were synthesized, which can alleviate tumor hypoxia, kill tumor cells, and enhance photothermal effect. The results of this study are of great significance for improving the efficacy of cancer therapy.
Article
Materials Science, Biomaterials
Anni Cui, Ying Bao, Haitao Xu, Xin Mu, Xiahua Zhong, Wynn Wee, Fanqi Wu, Guiye Shan
Summary: The rapid emergence of drug-resistant bacteria has led to the exploration of advanced antibacterial methods. However, single-modal therapy is not effective in completely eliminating drug-resistant bacteria. Therefore, achieving multi-modal antibacterial therapy is essential. This study designed a dual-modal ROS generator based on PMCL nanozymes for synergistic chemo-photodynamic therapy. With the synergistic effects, PMCL nanozymes achieved powerful antibacterial efficacy and eradication of bacterial biofilm.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Chenhao Wei, Mukun He, Maoqing Li, Xiao Ma, Wenlong Dang, Panbo Liu, Junwei Gu
Summary: Hollow Co/NC@MnO2 polyhedra with lightweight characteristics and enhanced synergistic effect are successfully fabricated via etching-pyrolysis-hydrothermal reaction, and they show high-efficiency microwave attenuation at a low filler loading of 20 wt%.
MATERIALS TODAY PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Man Wang, Chunzheng Yang, Mengyu Chang, Yulin Xie, Guoqing Zhu, Yanrong Qian, Pan Zheng, Qianqian Sun, Jun Lin, Chunxia Li
Summary: In this study, a large-pore mesoporous SAzyme loaded with macromolecular melittin pro-peptide was designed to achieve synergistic photodynamic therapy and ferroptosis, effectively inducing cancer cell death by inhibiting autophagy.
Article
Engineering, Biomedical
Yi Lu, Xinni Pan, Cheng Cao, Shanshan Fan, Haisong Tan, Shengsheng Cui, Yanlei Liu, Daxiang Cui
Summary: Acetaminophen, one of the most widely used drugs, is the main cause of acute liver injury. Research has found that nanozymes can effectively eliminate the overproduced reactive oxygen species in acetaminophen-induced liver injury (AILI). Mesoporous PdPt@MnO2 nanoprobes (PPM NPs) with peroxide, catalase, and superoxide dismutase-like properties were synthesized to address this issue. PPM NPs demonstrate nontoxicity, high colloidal stability, and exceptional reactive oxygen species (ROS)-scavenging ability. The study confirmed the pathology mechanism of PPM NPs in AILI by scavenging excessive ROS, reducing inflammatory cytokines, and inhibiting the recruitment and activation of monocyte/macrophage cells and neutrophils. Moreover, the therapeutic effect and biocompatibility of PPM NPs may facilitate the clinical treatment of AILI.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Weicai Wang, Xiaozu Chen, Junwei Li, Qiu Jin, Hyung Jong Jin, Xuemei Li
Summary: Nanotechnology provides new developments and challenges for cancer immunotherapy. By using nanomaterial-mediated synergistic therapy, immunosuppressive adjustment of the tumor microenvironment, and nanovaccine construction, the study was able to promote cancer immunotherapy. The research developed a tumor microenvironment-responsive nano-vaccine using a biodegradable hollow manganese dioxide platform, which significantly enhanced the immune response and achieved combined therapy benefits.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Shiyue Wu, Pu Zhang, Zhongwei Jiang, Wendong Zhang, Xue Gong, Yi Wang
Summary: The study successfully modulated the catalytic activity of nanozymes by combining the peroxidase (POD)-like activity and plasmon properties of CuS hollow nanocages. The CuS HNCs were found to have abundant hot spots, generating strong localized surface plasmon resonance (LSPR) effect, leading to a significant enhancement of POD-like activity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Kai Jiang, Xiangjing Cao, Haitao Wu, Yifeng Xu, Lulu Liu, Haisheng Qian, Zhaohua Miao, Hua Wang, Yan Ma
Summary: Pluronic F-127-coated tungsten diselenide (WSe2@F127) nanozymes effectively alleviate inflammatory bowel disease by eliminating reactive oxygen/nitrogen species, modulating gut microbiota, and remodeling the immune barrier.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Shiyue Wu, Pu Zhang, Zhongwei Jiang, Wendong Zhang, Xue Gong, Yi Wang
Summary: By combining the peroxidase-like activity and plasmon properties of CuS hollow nanocages, the catalytic activity of nanozymes can be modulated. A dual-mode strategy for detecting tannic acid has been developed based on the light-enhanced catalytic activity and high photothermal efficiency of the reaction system.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yafeng Wu, Zixuan Chen, Zhipeng Yao, Kaige Zhao, Fengying Shao, Juan Su, Songqin Liu
Summary: A versatile nanoprobe (H-MnO2/DOX/BPQDs) was developed for dual-modality cancer imaging and synergistic chemo-phototherapy, utilizing the distinct characteristics of black phosphorus quantum dots (BPQDs). The designed nanoprobe displayed dual-modality MRI/FL imaging and synergistic chemotherapy/PDT/PTT, ultimately enhancing the accuracy of cancer diagnosis and therapeutic performance.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xiaoyu Chen, Chunhua Zhao, Dingxin Liu, Kunpeng Lin, Jingnan Lu, Shuang Zhao, Jiang Yang, Huanxin Lin
Summary: This study reports a core-shell-structured Pd1.7Bi@CeO2-ICG (PBCI) nanoplatform for synergistic chemodynamic therapy (CDT), photodynamic therapy (PDT), and photothermal therapy. The PBCI nanoplatform can generate cytotoxic hydroxyl radicals for CDT and relieve tumor hypoxia for enhanced PDT. Additionally, it exhibits good photothermal effect and can be used as a contrast agent for near-infrared fluorescence imaging, enabling effective tumor elimination.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Environmental Sciences
Wenjing Zong, Zhaoming Guo, Minghuo Wu, Xianliang Yi, Hao Zhou, Siyuan Jing, Jingjing Zhan, Lifen Liu, Yang Liu
Summary: The study demonstrates that MnO2 materials can effectively remove endocrine-disrupting chemicals (EDCs), with delta-MnO2 showing the best removal performance for estrone (E1), and the redox reaction can facilitate this process.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Chemistry, Physical
Xinlian Zhao, Lulu Jin, Haifei Shi, Weijun Tong, Dmitry Gorin, Yuri Kotelevtsev, Zhengwei Mao
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2020)
Article
Chemistry, Physical
Jiawei Li, Tong Li, Dmitry Gorin, Yuri Kotelevtsev, Zhengwei Mao, Weijun Tong
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Biophysics
Tong Li, Huiqiang Qiu, Na Liu, Jiawei Li, Yuheng Bao, Weijun Tong
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Huanhuan Wang, Yuheng Bao, Huiqiang Qiu, Weijun Tong
Article
Chemistry, Analytical
Tong Li, Yuheng Bao, Huiqiang Qiu, Weijun Tong
Summary: Single atom nanomaterials with catalytic activity like natural enzymes, known as SAzymes, have gained attention in the past two years. However, most SAzymes are based on hydrophobic carbon, limiting their biomedical applications due to poor dispersal in water and weak substrate affinity.
ANALYTICA CHIMICA ACTA
(2021)
Article
Nanoscience & Nanotechnology
Yuheng Bao, Jifan Chen, Huiqiang Qiu, Cong Zhang, Pintong Huang, Zhengwei Mao, Weijun Tong
Summary: A novel strategy using erythrocyte membrane-camouflaged metal-organic framework nanoparticles for tumor treatment has been developed, which can enhance sonodynamic therapy efficiency by releasing oxygen inside tumor cells and improving biocompatibility through longer circulation time, ultimately inhibiting tumor growth.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Jiawei Li, Huiqiang Qiu, Hengtai Gong, Weijun Tong
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease with excessively high levels of reactive oxygen species (ROS) in the colon. Fabricating broad-spectrum ROS scavenging and activated macrophage-targeting microparticles (MPs) can effectively treat IBD by reducing inflammation and targeting activated macrophages.
Article
Biophysics
Huimin Wu, Tong Li, Yuheng Bao, Xinran Zhang, Chengcheng Wang, Chenjie Wei, Zhikang Xu, Weijun Tong, Dajing Chen, Xiaojun Huang
Summary: The study successfully addressed the limitation of 1D or 2D structures by assembling modified MOF-enzyme hybrid nanosystem into 3D porous conductive supports via a physical embedding method, showcasing high stability and catalytic performance. Furthermore, the multifunctional device integrated with conductive hollow fiber membranes demonstrated fast capillary fluid flow, trace sampling, high selectivity, and accuracy in sensing applications.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Oncology
Jifan Chen, Yuheng Bao, Yue Song, Cong Zhang, Fuqiang Qiu, Yu Sun, Lei Xin, Jing Cao, Yifan Jiang, Jiali Luo, Chao Zhang, Guowei Wang, Qunyin Li, Yajing Liu, Weijun Tong, Pintong Huang
Summary: A nanoplatform was developed to alleviate hypoxia in pancreatic cancer by catalyzing peroxide to oxygen with Pt nanoparticles, releasing drugs quickly in lysosome microenvironment to enhance cancer cell sensitivity to chemotherapy, and converting the produced oxygen into highly cytotoxic singlet oxygen under ultrasound exposure.
Review
Biochemistry & Molecular Biology
Haihan Song, Mengli Zhang, Weijun Tong
Summary: This review provides a comprehensive introduction and overview of single-atom nanozymes (SAzymes), including their preparation methods, characterization, surface modification, and applications in biomedical fields. The study is of great significance for increasing the atom utilization rate of nanozymes and developing novel biomedical materials.
Article
Engineering, Biomedical
Chao Li, Yu Chen, Yong Gao, Xin Wang, Jiaqiang Wang, Peng Zhang, Xiaobo Hu, Lei Li, Weijun Tong, Zhigang Ren, Weitao Yao
Summary: By utilizing PtF coordination-driven assembly, a stoichiometric coordination complex of camptothecin and organoplatinum (II) (Pt-CPT) was constructed, displaying synergistic antitumor effects. The Pt-CPT complex was encapsulated in an amphiphilic polymer with H2O2-responsiveness and glutathione-depleting ability (PO), resulting in the formation of Pt-CPT@PO nanomedicine with prolonged blood circulation and enhanced tumor accumulation. The Pt-CPT@PO nanomedicine exhibited remarkable synergistic antitumor efficacy and antimetastatic effect in a mice orthotopic breast tumor model.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Yuheng Bao, Yanni Ge, Mengjie Wu, Zhengwei Mao, Juan Ye, Weijun Tong
Summary: In this study, a highly efficient nitric oxide (NO) nanogenerator was developed by loading NO donor NMA into hyaluronic acid-modified hollow manganese dioxide nanoparticles. Under ultrasound irradiation, this nanogenerator can release Mn2+ at the tumor sites, leading to cascade tumor pyroptosis and cGAS-STING-based immunotherapy, effectively inhibiting tumor growth.
Article
Engineering, Biomedical
Zhixin Zhu, Haipeng Lu, Lulu Jin, Yong Gao, Zhefeng Qian, Pan Lu, Weijun Tong, Pik Kwan Lo, Zhengwei Mao, Haifei Shi
Summary: Neuroinflammatory responses following ischemic stroke lead to irreversible nerve cell death. Cell free-double strand DNA (dsDNA) segments from ischemic tissue debris are sensed by microglia's cyclic GMP-AMP synthase (cGAS), triggering the activation of the STING pathway and initiating chronic inflammatory cascade. In order to reduce neuroinflammation, the immunogenic dsDNA should be decomposed and the innate immune STING should be inhibited. A novel nano-drug was developed to balance the cGAS-STING axis for enhancing stroke therapeutics by combining a DNase-mimetic Ce4+ enzyme and STING inhibitor synergistically. It provides a new approach to modulating CNS inflammatory signaling pathways and improving stroke prognosis.
BIOACTIVE MATERIALS
(2023)
Review
Materials Science, Biomaterials
Mengli Zhang, Weijun Tong
Summary: With the advancement of nanotechnology, nanozymes have emerged as potential substitutes for natural enzymes due to their unique properties of nanomaterials, such as high activity, easy preparation, low cost, and robust stability. However, the constant activity of nanozymes in biomedical applications poses a potential threat to normal tissues. To address this issue, stimuli-responsive nanozymes have been designed to manipulate their activities. This review discusses two types of stimuli-responsive nanozymes, including those with stimuli-switchable activities and those exhibiting responsive release from specific carriers. The biomedical applications of stimuli-responsive nanozymes in cancer therapy, antibacterial therapy, biosensing, and anti-inflammatory therapy are also briefly explored. Finally, the challenges and prospects in this field are addressed.
BIOMATERIALS SCIENCE
(2023)
