IRF3-mediated pathogenicity in a murine model of human hepatitis A

Human liver CD8+ MAIT cells exert TCR/MR1-independent innate-like cytotoxicity in response to IL-15

(2020) Min-Seok Rha et al.   JOURNAL OF HEPATOLOGY

Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice

(2020) Tisha Melia et al.   PLoS One

The non-transcriptional activity of IRF3 modulates hepatic immune cell populations in acute-on-chronic ethanol administration in mice

(2019) Carlos Sanz-Garcia et al.   JOURNAL OF HEPATOLOGY

Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection

(2019) Taishi Kimura et al.   PLoS Pathogens

Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses

(2019) Daisuke Yamane et al.   Nature Microbiology

The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function

(2019) Nina Oberbeck et al.   NATURE

Innate-like Cytotoxic Function of Bystander-Activated CD8 + T Cells Is Associated with Liver Injury in Acute Hepatitis A

(2018) Jihye Kim et al.   IMMUNITY

Type A viral hepatitis: A summary and update on the molecular virology, epidemiology, pathogenesis and prevention

(2018) Stanley M. Lemon et al.   JOURNAL OF HEPATOLOGY

Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease

(2018) J.T. Qiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Murine Models of Hepatitis A Virus Infection

(2018) Asuka Hirai-Yuki et al.   Cold Spring Harbor Perspectives in Medicine

Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins

(2016) Heidi Gytz et al.   BIOLOGY OF THE CELL

Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis

(2016) Saurabh Chattopadhyay et al.   IMMUNITY

Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes

(2016) Arvin Iracheta-Vellve et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAVS-dependent host species range and pathogenicity of human hepatitis A virus

(2016) A. Hirai-Yuki et al.   SCIENCE

Biliary Secretion of Quasi-Enveloped Human Hepatitis A Virus

(2016) Asuka Hirai-Yuki et al.   mBio

IRF3 is an important molecule in the UII/UT system and mediates immune inflammatory injury in acute liver failure

(2016) Liang-ming Liu et al.   Oncotarget

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis

(2014) Volker Fensterl et al.   JOURNAL OF VIROLOGY

Human but Not Mouse Hepatocytes Respond to Interferon-Lambda In Vivo

(2014) Pascale Hermant et al.   PLoS One

MiR-942 Mediates Hepatitis C Virus-Induced Apoptosis via Regulation of ISG12a

(2014) Darong Yang et al.   PLoS One

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dominance of the CD4+T helper cell response during acute resolving hepatitis A virus infection

(2012) Yan Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA

(2011) R. E. Lanford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-stimulated gene ISG12b2 is localized to the inner mitochondrial membrane and mediates virus-induced cell death

(2010) M-Y Lu et al.   CELL DEATH AND DIFFERENTIATION

Viral apoptosis is induced by IRF-3-mediated activation of Bax

(2010) Saurabh Chattopadhyay et al.   EMBO JOURNAL

Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells

(2010) Jan Petrasek et al.   HEPATOLOGY

The Interferon Stimulated Gene 54 Promotes Apoptosis

(2010) Marcin Stawowczyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of CD8+ T-cell response in acute and resolved hepatitis A virus infection

(2010) I. Schulte et al.   JOURNAL OF HEPATOLOGY

Emerging Roles of FAM14 Family Members (G1P3/ISG 6–16 and ISG12/IFI27) in Innate Immunity and Cancer

(2010) Venugopalan Cheriyath et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene

(2009) A. Nakajima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

(2008) Markus Mordstein et al.   PLoS Pathogens