Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer

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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

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Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue

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Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy

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PARP Inhibitors in Endometrial Cancer: Current Status and Perspectives

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Development of a patient-derived explant model for prediction of drug responses in endometrial cancer

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Multiclonality and Marked Branched Evolution of Low-Grade Endometrioid Endometrial Carcinoma

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Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex

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Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

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Universal endometrial cancer tumor typing: How much has immunohistochemistry, microsatellite instability, and MLH1 methylation improved the diagnosis of Lynch syndrome across the population?

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Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets

(2019) Felicity Newell et al.   Nature Communications

A practical guide for mutational signature analysis in hematological malignancies

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Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

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Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series

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PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness

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Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas

(2018) Marthe M. de Jonge et al.   CLINICAL CANCER RESEARCH

Analysis of mutational signatures in primary and metastatic endometrial cancer reveals distinct patterns of DNA repair defects and shifts during tumor progression

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Establishment and characterization of uterine sarcoma and carcinosarcoma patient-derived xenograft models

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Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

(2017) Margherita Y. Turco et al.   NATURE CELL BIOLOGY

Patient-derived xenografts undergo mouse-specific tumor evolution

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HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

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Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes

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Prevention of Human Lymphoproliferative Tumor Formation in Ovarian Cancer Patient-Derived Xenografts

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Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer

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Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts

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Homologous recombination deficiency score shows superior association with outcome compared with its individual score components in platinum-treated serous ovarian cancer

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In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma

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The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis

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Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition

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(2015) Ann-Marie Patch et al.   NATURE

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

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Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells

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A Common Cancer-Associated DNA Polymerase   Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

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High Frequency ofRPL22Mutations in Microsatellite-Unstable Colorectal and Endometrial Tumors

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PyClone: statistical inference of clonal population structure in cancer

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Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro

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Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes

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MSIsensor: microsatellite instability detection using paired tumor-normal sequence data

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BMN 673, a Novel and Highly Potent PARP1/2 Inhibitor for the Treatment of Human Cancers with DNA Repair Deficiency

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Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

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Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Frequent mutations in the RPL22 gene and its clinical and functional implications

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Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

(2012) Sandra Misale et al.   NATURE

qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles

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Double strand break repair components are frequent targets of microsatellite instability in endometrial cancer

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PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors

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Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays

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