Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation

Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells

(2021) Blaise Su Jun Low et al.   Nature Communications

Inhibiting MARSs reduces hyperhomocysteinemia‐associated neural tube and congenital heart defects

(2020) Xinyu Mei et al.   EMBO Molecular Medicine

Vitamin B complex supplementation as a homocysteine-lowering therapy for early stage diabetic nephropathy in pediatric patients with type 1 diabetes: A randomized controlled trial

(2019) Nancy Samir Elbarbary et al.   CLINICAL NUTRITION

The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice

(2019) Rita Moretti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of SIRT1 by l-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes (l-serine activates SIRT1 in C2C12 myotubes)

(2019) Woo-Cheol Sim et al.   CELL BIOLOGY AND TOXICOLOGY

Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells

(2018) Shanshan Geng et al.   BIOMEDICINE & PHARMACOTHERAPY

Plasma Levels of Homocysteine and the Occurrence and Progression of Rectal Cancer

(2018) Zhi Liu et al.   MEDICAL SCIENCE MONITOR

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

(2018) Song-Yang Zhang et al.   EBioMedicine

Homocysteine Modification in Protein Structure/Function and Human Disease

(2018) Hieronim Jakubowski   PHYSIOLOGICAL REVIEWS

Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair

(2018) Dan Wang et al.   Cell Reports

Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function

(2016) Thorsten Hartmann et al.   Cardiovascular Diabetology

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum

(2016) Leena Haataja et al.   DIABETES

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

(2016) Qi Gong et al.   HEPATOLOGY

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Elevated homocysteine levels in type 2 diabetes induce constitutive neutrophil extracellular traps

(2016) Manjunath B Joshi et al.   Scientific Reports

Novel Clinical Evidence of an Association between Homocysteine and Insulin Resistance in Patients with Hypothyroidism or Subclinical Hypothyroidism

(2015) Ning Yang et al.   PLoS One

Homocysteine and the pathogenesis of atherosclerosis

(2015) Kilmer S McCully   Expert Review of Clinical Pharmacology

Acute Insulin Resistance Mediated by Advanced Glycation Endproducts in Severely Burned Rats

(2014) Xing Zhang et al.   CRITICAL CARE MEDICINE

Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations

(2013) J.-Y. Zhao et al.   EUROPEAN HEART JOURNAL

Folate: Metabolism, genes, polymorphisms and the associated diseases

(2013) Fakhira Hassan Nazki et al.   GENE

Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose Tissue

(2013) Yang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population

(2012) Jian-Yuan Zhao et al.   CELL RESEARCH

Sterol Regulatory Element-Binding Protein-1c Mediates Increase of Postprandial Stearic Acid, a Potential Target for Improving Insulin Resistance, in Hyperlipidemia

(2012) X. Chu et al.   DIABETES

Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy

(2012) A. V. Nair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

Functional Variant in Methionine Synthase Reductase Intron-1 Significantly Increases the Risk of Congenital Heart Disease in the Han Chinese Population

(2011) Jian-Yuan Zhao et al.   CIRCULATION

Functional Variants of the HMGA1 Gene and Type 2 Diabetes Mellitus

(2011) Eusebio Chiefari   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Genetics of homocysteine metabolism and associated disorders

(2010) S. Brustolin et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Phenotypical variety of insulin resistance in a family with a novel mutation of the insulin receptor gene

(2010) Ikuko Takahashi et al.   ENDOCRINE JOURNAL

Overproduction of Very Low–Density Lipoproteins Is the Hallmark of the Dyslipidemia in the Metabolic Syndrome

(2008) Martin Adiels et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In Vitro

(2008) Y. Li et al.   DIABETES

The correlation of plasma homocysteine with insulin resistance in polycystic ovary syndrome

(2008) Nafiye Yilmaz et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

The CAPN10 Gene Is Associated with Insulin Resistance Phenotypes in the Spanish Population

(2008) María E. Sáez et al.   PLoS One