Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements

Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues

(2021) Kotaro Hama et al.   Scientific Reports

Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia

(2021) Laurence C. Cheung et al.   Frontiers in Oncology

MiR-130b and miR-128a are essential lineage-specific co-drivers of t(4;11) MLL-AF4 acute leukemia

(2021) Camille Malouf et al.   BLOOD

HOXA9/IRX1 expression pattern defines two sub-groups of infant MLL-AF4-driven Acute Lymphoblastic Leukemia

(2020) V. Symeonidou et al.   EXPERIMENTAL HEMATOLOGY

Unravelling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis

(2019) Antonio Agraz-Doblas et al.   HAEMATOLOGICA

Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study

(2019) Rob Pieters et al.   JOURNAL OF CLINICAL ONCOLOGY

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

(2019) Sorcha O’Byrne et al.   BLOOD

Decoding human fetal liver haematopoiesis

(2019) Dorin-Mirel Popescu et al.   NATURE

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

(2019) Marteinn Thor Snaebjornsson et al.   Cell Metabolism

Phospholipids and cholesterol: Inducers of cancer multidrug resistance and therapeutic targets

(2019) Joanna Kopecka et al.   DRUG RESISTANCE UPDATES

The fetal liver lymphoid-primed multipotent progenitor provides the prerequisites for the initiation of t(4;11) MLL-AF4 infant leukemia

(2018) Camille Malouf et al.   HAEMATOLOGICA

High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia

(2018) Miriam Marquis et al.   Blood Cancer Journal

Polo-like kinase inhibitor volasertib marginally enhances the efficacy of the novel Fc-engineered anti-CD33 antibody BI 836858 in acute myeloid leukemia

(2018) Bhavani Gopalakrishnan et al.   Oncotarget

The fetal liver lymphoid-primed multipotent progenitor provides the prerequisites for the initiation of t(4;11) MLL-AF4 infant leukemia

(2018) Camille Malouf et al.   HAEMATOLOGICA

The Human Cell Atlas Bone Marrow Single-Cell Interactive Web Portal

(2018) Stuart Hay et al.   EXPERIMENTAL HEMATOLOGY

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

(2018) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation

(2017) Laura Godfrey et al.   EXPERIMENTAL HEMATOLOGY

The MLL recombinome of acute leukemias in 2017

(2017) C Meyer et al.   LEUKEMIA

Transcription control by the ENL YEATS domain in acute leukaemia

(2017) Michael A. Erb et al.   NATURE

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

(2017) Jon Kerry et al.   Cell Reports

Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries

(2017) Audrey Bonaventure et al.   Lancet Haematology

Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation

(2016) M. I. Mascarenhas et al.   BLOOD

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia

(2016) Shan Lin et al.   CANCER CELL

Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34 + HSPC But Is Insufficient to Initiate Leukemia

(2016) Cristina Prieto et al.   CANCER RESEARCH

RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation

(2016) Jayanth Kumar Palanichamy et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining the significance of IGF2BP1 overexpression in t(12;21)(p13;q22)-positive leukemia REH cells

(2016) Mindaugas Stoskus et al.   LEUKEMIA RESEARCH

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family

(2016) Bianca Busch et al.   NUCLEIC ACIDS RESEARCH

Kirsten Ras* oncogene: Significance of its discovery in human cancer research

(2016) Nobuo Tsuchida et al.   Oncotarget

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development

(2016) Neil A. Barrett et al.   Cell Reports

LIN28Boverexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia

(2015) Hetty H. Helsmoortel et al.   BLOOD

Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia

(2015) A. Sanjuan-Pla et al.   BLOOD

Phase I trial of volasertib, a Polo-like kinase inhibitor, in Japanese patients with acute myeloid leukemia

(2015) Yukio Kobayashi et al.   CANCER SCIENCE

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

(2015) Anna K Andersson et al.   NATURE GENETICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

MLL fusion-driven activation ofCDK6potentiates proliferation inMLL-rearranged infant ALL

(2014) Marieke Van der Linden et al.   CELL CYCLE

Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy

(2014) B T Gjertsen et al.   LEUKEMIA

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

(2014) Tessa G. Montague et al.   NUCLEIC ACIDS RESEARCH

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

PARP1 is required for chromosomal translocations

(2013) J. Wray et al.   BLOOD

HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia

(2013) Sujayita Roy et al.   LEUKEMIA & LYMPHOMA

The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells

(2013) Michael R. Copley et al.   NATURE CELL BIOLOGY

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

(2013) Adam C. Wilkinson et al.   Cell Reports

Hematopoietic Stem Cell Subtypes Expand Differentially during Development and Display Distinct Lymphopoietic Programs

(2012) Claudia Benz et al.   Cell Stem Cell

Very long-chain fatty acids: elongation, physiology and related disorders

(2012) A. Kihara   JOURNAL OF BIOCHEMISTRY

Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation

(2012) Marc Engelen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents

(2012) Ian G. Cowell et al.   International Journal of Environmental Research and Public Health

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

(2010) Y. Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting the role of mTOR: Lessons from mTOR inhibitors

(2009) Ryan J.O. Dowling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells

(2009) A. G. Renner et al.   BLOOD

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

(2009) D. Rudolph et al.   CLINICAL CANCER RESEARCH

Bone marrow mesenchymal stem cells from infants with MLL-AF4+acute leukemia harbor and express the MLL-AF4 fusion gene

(2009) Pablo Menendez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL