Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony

Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

(2021) Che-Wei Chang et al.   SCIENCE

Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission

(2020) Jie Zheng et al.   Cell Stem Cell

Activity-Dependent Plasticity of Axo-axonic Synapses at the Axon Initial Segment

(2020) Alejandro Pan-Vazquez et al.   NEURON

Tau Reduction Prevents Key Features of Autism in Mouse Models

(2020) Chao Tai et al.   NEURON

Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model

(2020) Masafumi Shimojo et al.   JOURNAL OF NEUROSCIENCE

Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro

(2020) Anke M. Tukker et al.   Scientific Reports

Association of epileptiform abnormalities and seizures in Alzheimer disease

(2020) Alice D. Lam et al.   NEUROLOGY

Targeting tau: Clinical trials and novel therapeutic approaches

(2020) Lawren VandeVrede et al.   NEUROSCIENCE LETTERS

Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome

(2020) Sam A. Booker et al.   Cell Reports

A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice

(2020) Kazuhiko Yamamuro et al.   NATURE NEUROSCIENCE

Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders

(2019) Vikaas S. Sohal et al.   MOLECULAR PSYCHIATRY

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments

(2019) Ronald S. Duman et al.   NEURON

A genetically encoded fluorescent sensor for in vivo imaging of GABA

(2019) Jonathan S. Marvin et al.   NATURE METHODS

Classification of electrophysiological and morphological neuron types in the mouse visual cortex

(2019) Nathan W. Gouwens et al.   NATURE NEUROSCIENCE

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

(2019) Peter Dongmin Sohn et al.   NEURON

A vicious cycle of β amyloid–dependent neuronal hyperactivation

(2019) Benedikt Zott et al.   SCIENCE

Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling

(2019) Monica Frega et al.   Nature Communications

Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse

(2018) Samuel Frere et al.   NEURON

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Modulation of excitation on parvalbumin interneurons by neuroligin-3 regulates the hippocampal network

(2017) Jai S Polepalli et al.   NATURE NEUROSCIENCE

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Spontaneous and Evoked Activity from Murine Ventral Horn Cultures on Microelectrode Arrays

(2017) Bryan J. Black et al.   Frontiers in Cellular Neuroscience

Tau exacerbates excitotoxic brain damage in an animal model of stroke

(2017) Mian Bi et al.   Nature Communications

Incidence and impact of subclinical epileptiform activity in Alzheimer's disease

(2016) Keith A. Vossel et al.   ANNALS OF NEUROLOGY

Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

(2016) Sumihiro Maeda et al.   EMBO REPORTS

Cooperative Interactions between 480 kDa Ankyrin-G and EB Proteins Assemble the Axon Initial Segment

(2016) A. Freal et al.   JOURNAL OF NEUROSCIENCE

Management of psychiatric and neurological comorbidities in epilepsy

(2016) Andres M. Kanner   Nature Reviews Neurology

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Inhibitory Circuits in Cortical Layer 5

(2016) Alexander Naka et al.   Frontiers in Neural Circuits

Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells

(2015) Carmen Laura Sayas et al.   JOURNAL OF NEUROCHEMISTRY

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

Molecular mechanisms of epilepsy

(2015) Kevin Staley   NATURE NEUROSCIENCE

Pathological Tau Disrupts Ongoing Network Activity

(2015) Noa Menkes-Caspi et al.   NEURON

Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing

(2015) Mark D. Evans et al.   Cell Reports

High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration

(2015) Jeanna M. Wheeler et al.   Acta Neuropathologica Communications

Tau reduction prevents disease in a mouse model of Dravet syndrome

(2014) Ania L. Gheyara et al.   ANNALS OF NEUROLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome

(2014) C. Tai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimfit: quantifying electrophysiological data with Python

(2014) Segundo J. Guzman et al.   Frontiers in Neuroinformatics

Calcineurin Signaling Mediates Activity-Dependent Relocation of the Axon Initial Segment

(2013) M. D. Evans et al.   JOURNAL OF NEUROSCIENCE

Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy

(2013) J. K. Holth et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction

(2013) Ethan M. Goldberg et al.   NATURE REVIEWS NEUROSCIENCE

Hyperexcitability and epileptic seizures in a model of frontotemporal dementia

(2013) Ana M. García-Cabrero et al.   NEUROBIOLOGY OF DISEASE

Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy

(2012) Johanna L. Crimins et al.   ACTA NEUROPATHOLOGICA

The Physiology of the Axon Initial Segment

(2012) Kevin J. Bender et al.   Annual Review of Neuroscience

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Changes in Neural Circuit Topology Following Mild Mechanical Injury In Vitro

(2011) Tapan P. Patel et al.   ANNALS OF BIOMEDICAL ENGINEERING

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Short- and Long-Term Plasticity at the Axon Initial Segment

(2011) M. S. Grubb et al.   JOURNAL OF NEUROSCIENCE

End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment

(2011) C. Leterrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism and epilepsy: Historical perspective

(2010) Roberto Tuchman et al.   BRAIN & DEVELOPMENT

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability

(2010) Matthew S. Grubb et al.   NATURE

Presynaptic activity regulates Na+ channel distribution at the axon initial segment

(2010) Hiroshi Kuba et al.   NATURE

Epileptogenesis in the immature brain: emerging mechanisms

(2009) Sanjay N. Rakhade et al.   Nature Reviews Neurology