Article
Engineering, Biomedical
Zesheng Chen, Tao Hu, Rui Wang, Bohan Huang, Lingfeng Tu, Guanyi Wang, Cao Li, Binghai Dong, Zijian Wang, Weikang Hu
Summary: This study successfully integrates antibacterial polymers and pro-regenerative small molecules through the fabrication of antibacterial composite hydrogels and the construction of composite microneedles, providing a promising therapeutic platform for treating infected and chronic wounds.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Yasaman Ghiyasi, Philip D. Prewett, Graham J. Davies, Zahra Faraji Rad
Summary: Chronic wounds occur due to various reasons, including trauma, accidents, and diseases. Diabetes is a major cause of non-healing wounds, and the number of people with diabetes is increasing globally. Microneedles (MNs) offer a promising solution for the treatment of chronic wounds, as they provide an effective and non-invasive way to deliver drugs and accelerate the healing process.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Wei Liu, Xingxing Zhai, Xue Zhao, Yongjie Cai, Xinmei Zhang, Kai Xu, Jie Weng, Jianshu Li, Xingyu Chen
Summary: Chronic nonhealing diabetic wounds are a serious complication of diabetes, and a multifunctional double-layer microneedle (DMN) has been developed to address the challenges in wound healing, including infection control and angiogenesis promotion.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Engineering, Biomedical
Shang Lyu, Zhifei Dong, Xiaoxiao Xu, Ho-Pan Bei, Ho-Yin Yuen, Chung-Wai James Cheung, Man-Sang Wong, Yong He, Xin Zhao
Summary: Microneedles have gained widespread attention as a novel drug delivery system due to their non-invasiveness, painless administration, controllable drug delivery, and versatile cargo loading capacity. In addition to transdermal drug delivery, microneedles have shown promising results in promoting wound healing and tissue regeneration. This review provides an overview of microneedle systems, including potential cargos, structural designs, material selection, and drug release mechanisms. It also summarizes different fabrication methods and the recent progress of microneedle-assisted wound healing and tissue regeneration in various tissues and organs.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Shun Yao, Junjie Chi, Yuetong Wang, Yuanjin Zhao, Yuan Luo, Yongan Wang
Summary: A degradable zinc-MOF encapsulated microneedles array was fabricated in this study, showing excellent antibacterial activity and biocompatibility, which can accelerate wound healing and tissue regeneration.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Jungho Lee, Sebin Park, Phuong Thao Le, Geunho Lee, Hyoun Wook Lee, Gaeun Yun, Juhyeong Jeon, Jeongwoo Park, Duy Tho Pham, Young Sook Park, Hoon Lim, Chulhong Kim, Tae Sik Hwang, Seung Whan Kim, Geunbae Lim
Summary: In this study, a shelf-stable dissolving microneedle (MN) patch is developed to prevent rebleeding during an emergency treatment. A minimally invasive hemostatic drug delivery system is established using a peripheral MN (p-MN) patch that enables topical drug absorption in the damaged capillaries. The invasiveness of MNs is examined through histological examination and the skin penetration force is quantified to demonstrate the milder administration of the p-MN patch compared to conventional MN patches. Hemostatic performance is studied systematically and the superior performance of the p-MN patch is demonstrated in an in vivo rat model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Ovidio Catanzano, Fabiana Quaglia, Joshua S. Boateng
Summary: Recent research has shifted focus from passive wound dressings to advanced dressings that actively promote wound healing. The use of growth factors (GFs) to accelerate wound healing and reduce scar formation is considered a feasible therapeutic approach, with the integration of micro- and nanotechnologies offering control over GF release rates. Multiple studies have shown promising outcomes in in vitro and in vivo wound models, leading to the expectation that some of these technologies will meet clinical needs and become commercially available.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Biochemistry & Molecular Biology
Ye Wang, Qida Zong, Huiying Wu, Yan Ding, Xi Pan, Bo Fu, Wei Sun, Yinglei Zhai
Summary: This review summarizes recent studies on the application of microneedles in wound healing, classifies microneedles according to their functions in the process, and discusses the current challenges and future directions of their clinical translation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Abigail L. Lauterbach, Anna J. Slezak, Ruyi Wang, Shijie Cao, Michal M. Raczy, Elyse A. Watkins, Carlos J. Medina Jimenez, Jeffrey A. Hubbell
Summary: Butyrate, an important bacterial metabolite, has a complex role in regulating immunity and maintaining epithelial barriers. However, its clinical translation is hindered by poor bioavailability, strong odor, and high dosage requirements. A novel polymeric delivery platform has been developed for controlled release of butyrate, which also has potential for other therapeutically relevant metabolites. This platform shows efficacy in the treatment of non-healing diabetic wounds by modulating immune cell activation and altering the soluble signals in the wound microenvironment, addressing a significant clinical need.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Ying Zhang, Shenqiang Wang, Yinxian Yang, Sheng Zhao, Jiahuan You, Junxia Wang, Jingwei Cai, Hao Wang, Jie Wang, Wei Zhang, Jicheng Yu, Chunmao Han, Yuqi Zhang, Zhen Gu
Summary: The authors developed a core-shell structured microneedle array patch with programmed functions to dynamically modulate the wound immune microenvironment according to different healing phases. This patch promotes scarless wound repair and inhibits the formation of hypertrophic scars.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Xuejing Yang, Wenyu Cao, Xun Gu, Lijie Zheng, Qiuyue Wang, Yingying Li, Fang Wei, Tao Ma, Lu Zhang, Qingqing Wang
Summary: One of the main problems in wound healing therapy is inefficient drug delivery. A new drug delivery system using dissolving microneedles to deliver SIM nanocrystals to deep wound areas has been designed and evaluated. The results show that the solubility of SIM is significantly improved after the preparation of SIM nanocrystals. The SIM nanocrystals are efficiently released into the wound area for optimal therapeutic efficacy. This drug delivery system has great potential in promoting wound healing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Wen Zhang, Wenqi Liu, Linyu Long, Shuyi He, Zhicun Wang, Yang Liu, Li Yang, Ningbo Chen, Cheng Hu, Yunbing Wang
Summary: The harsh microenvironment and poor tissue regeneration ability of chronic diabetic wounds make them difficult to cure. A new approach using smart-responsive multi-functional hydrogels has been developed to improve the healing of such wounds. These hydrogels can quickly respond to the acidic environment of diabetic wounds and release multiple drugs in a sequential manner. In vitro and in vivo experiments have shown that these hydrogels effectively eliminate bacteria, relieve inflammation, and promote angiogenesis, thereby accelerating the closure of chronic diabetic wounds.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Erfan Rezvani Ghomi, Mohamadreza Shakiba, Ali Saedi Ardahaei, Mahsa Akbari Kenari, Mehdi Faraji, Shahla Ataei, Parisa Kohansal, Iman Jafari, Majid Abdouss, Seeram Ramakrishna
Summary: Wound healing is a complex process involving different cells, cytokines, and growth factors. Chronic ulcers, however, cannot heal naturally and cause significant problems for patients and society. Therefore, innovative drug delivery systems to accelerate the healing process of chronic wounds are urgently needed.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Pharmacology & Pharmacy
Jobin Jose, Kartik Bhairu Khot, Prajna Shastry, Simi P. Thomas, Hitesh Chopra, Gopika Gopan, Akshay Bandiwadekar, Alex Babu, Sanjay R. Ugare, Ghulam Md Ashraf, Archana Dhyani, Vidhi Vora
Summary: The traditional methods of transdermal drug delivery have limitations due to the barrier function of the skin's stratum corneum. Microneedles offer a promising solution to this problem, providing a noninvasive and painless way to deliver drugs and enhance wound healing. Different types of microneedles are used in the fabrication of patches for wound healing strategies, and their effects are closely monitored by researchers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Engineering, Chemical
Shahram Emami, Mohsen Ebrahimi
Summary: Powders are commonly used for drug delivery, and bioactive wound powders (BWPs) have gained attention for wound dressings and drug delivery systems. BWPs have features such as stability, rapid effect, applicability to various wounds, exudate absorption, in-situ hydrogel formation, and no need for dressing change. This review discusses the composition, properties, fabricating techniques, and commercialized products of BWPs.
Review
Engineering, Multidisciplinary
Kun Li, Junwei Xu, Ping Li, Yubo Fan
Summary: Magnetic ordered materials based on MNPs have unique advantages in biomedical applications, and future research should focus on safety, functionality, and structural diversity for interdisciplinary studies.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Xianda Yang, Weirong Zhang, Jie Yao, Anqiang Sun, Yuanming Gao, Meng Guo, Yubo Fan
Summary: This study utilized finite element analysis to simulate the degradation process of poly (lactic-co-glycolic acid) stent, revealing that the fracture time of the stent was delayed by 63% in the surface degradation mode compared to bulk degradation. This indicates significant differences in mass loss rate and scaffolding period between surface degradation and bulk degradation.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Lurong Jia, Chunjuan Wang, Chao Wang, Jinlin Song, Yubo Fan
Summary: This study evaluated the biomechanical effects of various multi-layers of clear aligners on maxillary anterior teeth retraction, showing that increasing soft layer thickness led to decreased tooth displacement, periodontal ligament pressure, and stress. Additionally, higher soft/hard layers ratio resulted in decreased elastic strain of clear aligners. Multi-layer clear aligners were found to be more effective in tooth movement and stress distribution compared to single-layer clear aligners, especially when the soft layer to hard layer ratio exceeded 50%.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Ronghui Liu, Chang Jin, Lizhen Wang, Yisong Yang, Yubo Fan, Weidong Wang
Summary: The study developed a simulation using finite element analysis to evaluate the outcome of stent retriever thrombectomy for clots of different sizes and frictional properties. By characterizing the mechanical behavior of stent retrievers and clots, the simulation method offers a potential tool for optimizing device design and selecting surgical strategies.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Polymer Science
Lichuang Zhang, Xiali Guan, Xiongfu Xiao, Yixin Chai, Zhigang Chen, Gang Zhou, Yubo Fan
Summary: An injectable ferrimagnetic chitosan thermosensitive hydrogel was developed for precise and responsive controlled release of drugs in cancer treatment, showing synergistic effect and sustained treatment in tumor cells killing with good biocompatibility.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Xin-Tong Wu, Xiao Yang, Ran Tian, Ying-Hui Li, Chun-Yan Wang, Yu-Bo Fan, Lian-Wen Sun
Summary: Decades of spaceflight studies have shown that cells are capable of sensing and responding to microgravity in space through cytoskeletal reorganization. The disruption of cytoskeletal equilibrium by the shift from ground to space gravity leads to cellular changes in morphology, mechanical properties, extracellular matrix, and signaling pathways, ultimately affecting cell functionality in microgravity.
Article
Engineering, Biomedical
Qisheng Xiong, Ningze Zhang, Miaomiao Zhang, Meng Wang, Lizhen Wang, Yubo Fan, Chia-Ying Lin
Summary: Breast cancer bone metastasis is influenced by the local microenvironment, specifically the pre-metastatic niche, which affects the propensity of cancer cells to invade and colonize secondary sites. Tissue-engineering scaffolds, such as PCL-nHA, promote osteogenic differentiation and create a favorable environment for cancerous invasion. The study demonstrated increased mRNA levels of key markers for osteogenesis on the PCL-nHA scaffolds compared to control, indicating a more conducive niche for cancer cell migration. Furthermore, confirmation of the mediator CXCL12 and its role in promoting migration highlights the potential of tissue engineering scaffolds to mimic the bone microenvironment and study breast cancer metastasis.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Engineering, Multidisciplinary
Kun Li, Junwei Xu, Jingxi Wang, Xuenan Gu, Ping Li, Yubo Fan
Summary: In this study, oriented hydrogel film and chitosan hydrogel film with gradient nanofibrous structure and mechanical property were prepared using the stretching-drying method. These films show great potential in inducing cell migration, orientation, and differentiation.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Multidisciplinary
Meili Liu, Chongquan Huang, Junwei Xu, Zitong An, Xiaomeng Deng, Gang Zhou, Ping Li, Yubo Fan
Summary: This study demonstrated that magnetic materials can effectively promote neuronal growth under magnetic field loading. Fe3O4@PLGA RBC-like MPs, with a red blood cell-like shape, were constructed and shown to significantly increase cell viability and growth indices in primary cultured cortical neurons when combined with magnetic field loading. Additionally, the protective effect of these magnetic particles and magnetic field loading was demonstrated in mice sciatic nerve injury.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Zhuang Han, Lian-Wen Sun, Xin-Tong Wu, Xiao Yang, Yu-Bo Fan
Summary: This study investigates the time-dependent changes and structural characteristics of the membrane skeleton in osteocytes under vibration stimulation. Results show that the membrane skeleton is affected by vibrations and undergoes dynamic responses and structural changes. The vibration at 15Hz has the most destructive effect on the membrane skeleton, suggesting a natural frequency below 15Hz. Chaos phenomena occur in the membrane skeleton during vibration, and the presence of viscosity helps mitigate structural damage.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Xiaoling Jia, Chao Gao, Xia Wang, Lin-Hua Jiang, Yubo Fan
Summary: This study found that mechanical stretch had different effects on the expressions of BKCa and L-VDCC channels in rat uterine smooth muscle cells, with stretch down-regulating BKCa channel expression but upregulating L-VDCC channel expression.
JOURNAL OF MEMBRANE BIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Xinpeng Wang, Hongzhang Wang, Kang Sun, Wanjun Li, Xuelin Wang, Xuanqi Chen, Liang Hu, Yubo Fan
Summary: This study presents a reconfigurable and sustainable liquid metal oxide as an adsorbent for efficient removal of the azo dye Ponceau S in water. The gallium-based alloy exhibits excellent reconfigurability and fluidity, allowing continuous production of surface gallium oxide for adsorption. The adsorption process is fast, energy-saving, and easily reversible. Furthermore, the electrical conductivity of liquid gallium enables impedance sensing for quantification of the adsorption process. This research provides a unique approach for the design and fabrication of adsorbents with continuous and multifunctional performance and opens up possibilities for applications in dye adsorption, environmental engineering, and molecular monitoring.
APPLIED MATERIALS TODAY
(2022)
Article
Biotechnology & Applied Microbiology
Shaowei Jia, He Gong, Yingying Zhang, Hongmei Liu, Haipeng Cen, Rui Zhang, Yubo Fan
Summary: This study assessed and predicted femoral strength and its influencing factors in elderly men with type 2 diabetes mellitus (T2DM). The results showed that femoral strength was higher in the T2DM group, which may be caused by higher bone mineral density and lower bone turnover rate. In addition to bone density and bone formation level, advanced glycation end products (AGEs), blood glucose, and age may significantly impact the prediction of femoral strength in T2DM.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Tianming Du, Zhengwei Li, Xiaoming Li, Xufeng Niu, Yubo Fan
Summary: By adjusting the charge balance mechanism of polyelectrolyte compounds and osmotic pressure, the formation of intrafibrillar mineralization is promoted, providing a basis for the preparation of biomimetic mineralized materials and the development of tissue engineering.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yuwei Zhang, Lizhen Wang, Hongyan Kang, Chia-Ying Lin, Yubo Fan
Summary: This study investigated the inducibility of irisin in vitro and found that stretching myotubes can lead to a surge of irisin secretion, which is associated with the shift of myosin heavy chain isoforms. The expression of PGC-1 alpha 1 and PGC-1 alpha 4, rather than PGC-1 alpha 2 and PGC-1 alpha 3, contributes to the generation of irisin during cyclic strain. Additionally, the bioactivity of generated irisin was demonstrated in promoting osteogenic differentiation.