Article
Multidisciplinary Sciences
Johannes J. Kovarik, Andrea Bileck, Gerhard Hagn, Samuel M. Meier-Menches, Tobias Frey, Anna Kaempf, Marlene Hollenstein, Tarik Shoumariyeh, Lukas Skos, Birgit Reiter, Marlene C. Gerner, Andreas Spannbauer, Ena Hasimbegovic, Doreen Schmidl, Gerhard Garhofer, Mariann Gyongyosi, Klaus G. Schmetterer, Christopher Gerner
Summary: In order to understand the pathophysiology of long COVID-19 syndrome (LCS), an exploratory study was conducted using blood plasma samples from three groups: healthy vaccinated individuals without SARS-CoV-2 exposure, asymptomatic recovered patients at least three months after SARS-CoV-2 infection, and symptomatic patients at least three months after SARS-CoV-2 infection with LCS. The study found that recovered individuals had slightly elevated pro-inflammatory cytokine levels compared to patients with LCS. Additionally, LCS patients showed low levels of acute phase proteins and macrophage-derived secreted proteins, but high levels of anti-inflammatory oxylipins and osmolytes. The study proposes that alternatively polarized macrophages may be a major contributor to these molecular alterations.
Article
Plant Sciences
Nana Su, Ze Liu, Lu Wang, Yuanyuan Liu, Mengyang Niu, Xin Chen, Jin Cui
Summary: This study reveals that hemin treatment increases anthocyanin accumulation in radish sprouts through HO-1 and NO signaling network.
Article
Immunology
Wen-Lin Su, Chih-Pei Lin, Hui-Ching Hang, Ping-Sheng Wu, Ching-Feng Cheng, You-Chen Chao
Summary: Increased heme levels, anemia, and desaturation occur during infection. Heme and HO-1 enzyme levels significantly increased in the low SpO(2) group, but further studies are required.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Chemistry, Multidisciplinary
Fan Chen, Baoxin Zhang, Zhenjiang Ding, Miao Zhong, Yanan Hou, Fang Zhang, Guodong Hu, Jianguo Fang
Summary: We report a new fluorescent probe, RBH, for imaging HO-1 activity in live cells, utilizing hemin as a universal static quencher. RBH has favorable properties such as long excitation/emission wavelengths, fast response rate, and high signal increase, enabling its use for determining HO-1 activity in complex biological samples. The discovery of hemin as a general static dark quencher provides a straightforward strategy for constructing novel fluorescent probes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Maria G. Detsika, Ioanna Nikitopoulou, Dimitris Veroutis, Alice G. Vassiliou, Edison Jahaj, Stamatis Tsipilis, Nikolaos Athanassiou, Hariklia Gakiopoulou, Vassilis G. Gorgoulis, Ioanna Dimopoulou, Stylianos E. Orfanos, Anastasia Kotanidou
Summary: The increase in HO-1 expression observed in critically ill COVID-19 patients is associated with disease progression and poor outcome. The upregulation of HO-1 in blood and tissues of severe patients may serve as a protective mechanism against coagulation and thrombosis.
Article
Critical Care Medicine
Xue Cheng, Mingzhu Yin, Xiongjie Sun, Zhigang Zhang, Xiaowei Yao, Hongtao Liu, Hui Xia
Summary: Pulmonary epithelial barrier injury contributes to acute lung injury, while heme oxygenase-1 (HO-1) plays a role in ameliorating the symptoms. This study investigated the potential molecular effect of hemin, a HO-1 inducer, on ALI epithelial damage in a mouse model. Hemin treatment effectively reversed the pathological changes triggered by lipopolysaccharide challenge, including dysfunction of the alveolar epithelial barrier and impaired clearance of alveoli fluid.
Article
Biochemistry & Molecular Biology
Hanxia Huang, Alena Dabrazhynetskaya, Jacob Pluznik, Jiwen Zheng, Yong Wu, Vladimir Chizhikov, Paul W. Buehler, Kenneth M. Yamada, Subhash Dhawan
Summary: Hemin has a significant inhibitory effect on the replication of M. hyorhinis in chronically infected prostate cancer cells, with over 90% inhibition. This effect is mediated through the induction of HO-1 protein expression, leading to increased intracellular levels of M. hyorhinis DNA. The study suggests that activated HO-1 has therapeutic potential in cellular innate responses against mycoplasma infection.
Article
Medicine, Research & Experimental
Sheila Maestro, Karol M. Cordoba, Cristina Olague, Josepmaria Argemi, Matias A. Avila, Gloria Gonzalez-Aseguinolaza, Cristian Smerdou, Antonio Fontanellas
Summary: Although hemin, a natural inducer of the heme oxygenase-1 gene, significantly up-regulated HO-1 expression, it was unable to inhibit or delay the progression of SARS-CoV-2 infection in two susceptible epithelial cell lines. Further research is needed to explore its antiviral effect.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Hsin-Yi Chen, I-Shiang Tzeng, Kuo-Wang Tsai, Yao-Kuang Wu, Ching-Feng Cheng, Kuo-Cheng Lu, Hsueh-Wen Chung, You-Chen Chao, Wen-Lin Su
Summary: HO-1 levels increase with sepsis development within 48 h of admission for COVID-19 after adjusting for other risk factors, but no significant association was observed between HO-1 and COVID-19 mortality. Further clinical multicenter prospective studies are needed to clarify the potential protective effect of HO-1 in early sepsis.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Surya K. K. De
Summary: COVID-19 is treated with Paxlovid, a drug composed of Nirmatrelvir and Ritonavir, which obtained emergency use authorization from the FDA on December 22, 2021. These drugs are peptidomimetic inhibitors of the coronavirus main protease. The patent discusses similar proline-like compounds, their preparation, use, pharmaceutical composition, and treatment.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Shobha Regmi, Pawan Kumar Raut, Shiva Pathak, Prakash Shrestha, Pil-Hoon Park, Jee-Heon Jeong
Summary: The study found that 3D-cultured MSCs (MSC3D) showed highly induced autophagy and suppressed ROS production compared to 2D-cultured MSCs (MSC2D). Autophagy induction significantly influenced the cell viability and apoptotic activity in MSC3D. The HIF1A-HMOX1 axis played a crucial role in modulating ROS production and autophagy induction in MSC3D.
Article
Medicine, Research & Experimental
Franciele de Lima, Carla Roberta Peachazepi Moraes, Mayck Silva Barbosa, Bruna Bombassaro, Andre C. Palma, Sergio San Juan Dertkigil, Maria Luiza Moretti, Fernanda Andrade Orsi, Joyce M. Annichino-Bizzacchi, Eli Mansour, Licio A. Velloso, Erich Vinicius De Paula
Summary: Heme-oxygenase 1 (HO-1) is an enzyme with anti-inflammatory and antioxidant properties, and its levels have been associated with disease severity in various diseases. The heme/HO-1 pathway has also been linked to prothrombotic changes. This study aimed to investigate the association between HO-1, heme, and hemopexin (HPX) levels with COVID-19 severity and markers of inflammation and coagulation activation.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
William Durante
Summary: The COVID-19 pandemic has resulted in the deaths of nearly 7 million people worldwide. Clinical data has revealed a deficiency of circulating glutamine in COVID-19 patients, which is associated with disease severity. The disturbed glutamine metabolism may lead to immune and endothelial cell dysfunction, causing severe infection, inflammation, oxidative stress, vasospasm, and coagulopathy, ultimately resulting in vascular occlusion, multi-organ failure, and death. Strategies that restore glutamine levels, its metabolites, and/or downstream effectors, in combination with antiviral drugs, offer a promising therapeutic approach to restore immune and endothelial cell function and prevent occlusive vascular disease in COVID-19 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tianrun Zheng, Junyi Zhan, Ming Yang, Maojia Wang, Wenjun Sun, Zhi Shan, Hui Chen
Summary: The study demonstrates that hemin can increase saponin synthesis in plants by enhancing photosynthetic capacity and promoting the expression of key enzyme genes, thus increasing saponin content and alleviating damage caused by environmental stress.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Editorial Material
Chemistry, Medicinal
C. S. Brian Chia, Yi Yang See
Summary: COVID-19, caused by the SARS-CoV-2 coronavirus, has rapidly become a global pandemic with millions of fatalities. The development of antiviral drugs targeting the virus is ongoing, including peptide inhibitor nirmatrelvir and azadipeptide peptidomimetic inhibitors.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Food Science & Technology
Mengxiao Song, Md Iqbal Hossain, Soontag Jung, Daseul Yeo, Zhaoqi Wang, Ae Min, Ziwei Zhao, Sunho Park, Changsun Choi
Summary: This study compared the efficacy of four commercial liquid disinfectants on hepatitis A virus using carrier and suspension testing methods. The results showed that high concentrations of ClO2 and ethanol were effective in carrier testing, while NaOCl and ClO2 were effective in suspension testing. The study recommends using ClO2 at concentrations above 500 ppm or 50% ethanol with a 10-minute exposure to disinfect surfaces potentially contaminated with HAV.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Food Science & Technology
Kye-Hwan Byun, Sang Ha Han, Min Woo Choi, Si Hong Park, Sang-Do Ha
Summary: This study evaluated the efficacy of a bacteriophage cocktail as a biocontrol agent against L. monocytogenes in celery and enoki mushroom. The results showed that the phage cocktail can effectively inhibit the growth of L. monocytogenes in these foods, making it a potential candidate for biocontrol purposes.
Article
Biotechnology & Applied Microbiology
Shamsun Nahar, Ha Lim Jeong, Ah Jin Cho, Jun-Ha Park, Sangha Han, Younsoo Kim, Si-Hong Park, Sang-Do Ha
Summary: This study investigated the biofilm reduction effects of a food-grade enzyme (ficin) and a common sanitizer (PAA) on Salmonella. Results showed that ficin could enhance the efficacy of PAA in reducing biofilm. The combined use of enzyme and sanitizer proved promising in addressing food safety issues.
Article
Biotechnology & Applied Microbiology
Kye-Hwan Byun, Kyung Won Na, Md Ashrafudoulla, Min Woo Choi, Sang Ha Han, Iksoon Kang, Si Hong Park, Sang-Do Ha
Summary: The combination treatment of PAA or LA with UV-C significantly reduced Salmonella Enteritidis biofilms on food contact surfaces and chicken skin.
Article
Food Science & Technology
Sazzad Hossen Toushik, Jun-Ha Park, Kyeongjun Kim, Md Ashrafudoulla, Mevo Senakpon Isaie Ulrich, Md Furkanur Rahman Mizan, Pantu Kumar Roy, Won-Bo Shim, Young-Mog Kim, Si Hong Park, Sang-Do Ha
Summary: The study shows that bioactive substances from lactic acid bacteria and plant-derived essential oils can act as biocidal agents, efficiently inhibiting biofilm formation on seafood processing surfaces and potentially serving as preservatives in the seafood industry.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Agriculture, Dairy & Animal Science
I Kang, H. C. Lee, B. Adhikari, S. D. Ha, Y. M. Kwon
Summary: The combination of subzero saline chilling and hot water spray significantly reduces bacterial contamination on broiler carcasses, especially for mesophilic aerobic bacteria, Escherichia coli, and total coliforms.
Article
Food Science & Technology
Yu Kyung Kim, Pantu Kumar Roy, Md Ashrafudoulla, Shamsun Nahar, Sazzad Hossen Toushik, Md Iqbal Hossain, Md Furkanur Rahaman Mizan, Si Hong Park, Sang -Do Ha
Summary: Salmonellosis is a common food poisoning disease that affects millions of people worldwide. Quercetin, an antioxidant and antibacterial compound, has been found to inhibit biofilm formation and downregulate the expression of virulence and stress response genes in Salmonella spp.
Article
Food Science & Technology
Ae Min, Md Iqbal Hossain, Soontag Jung, Daseul Yeo, Zhaoqi Wang, Mengxiao Song, Ziwei Zhao, Sunho Park, Changsun Choi
Summary: This study evaluated the antiviral efficacy of three disinfectants on food-contact surfaces using a carrier testing method. Ethanol and peracetic acid showed effective antiviral activity, while quaternary ammonium compounds were ineffective. Comparison with suspension testing showed that ethanol and peracetic acid exhibited the best antiviral efficacy.
Review
Food Science & Technology
Sangha Han, Seok-Woo Hyun, Jeong Won Son, Min Su Song, Dong Jae Lim, Changsun Choi, Si Hong Park, Sang-Do Ha
Summary: Various foodborne viruses have caused gastroenteritis and had a significant economic impact globally in the past decade. The emergence of new variants of infectious viruses continues to grow. Inactivating foodborne viruses in the food industry is challenging because they can survive in the food matrix during processing and storage. Conventional methods have limitations, necessitating more effective and environmentally friendly techniques. Nonthermal techniques are considered a new platform for safe and effective treatment to inactivate foodborne viruses.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Article
Biotechnology & Applied Microbiology
Soontag Jung, Daseul Yeo, Zhaoqi Wang, Seoyoung Woo, Yeeun Seo, Md Iqbal Hossain, Changsun Choi
Summary: Since the first SARS-CoV-2 outbreak in Wuhan, there has been concern over the link between SARS-CoV-2 transmission and food. This study evaluated the viability of SARS-CoV-2 on different types of food and found that the virus can persist longer at lower temperatures. Disinfectants such as 70% ethanol and ClO2 were effective in reducing the virus on food, while peracetic acid was able to eliminate it completely.
Article
Food Science & Technology
Yoonjeong Yoo, Miseon Sung, Jeongeun Hwang, Daseul Yeo, Ziwei Zhao, Changsun Choi, Yohan Yoon
Summary: This study estimated the risk of hepatitis A virus (HAV) foodborne illness outbreaks through the consumption of fermented clams in South Korea. The results showed that while there is a low likelihood of HAV foodborne illness from consuming fermented clams across the country, regular consumers should be aware of the possibility of foodborne illness.
Article
Food Science & Technology
Eun-Ji Han, Eun-Young Choi, Su -Ji Jeon, Sang-Woo Lee, Jun-Mo Moon, Soo-Hyun Jung, Bumseok Kim, Sung-Dae Cho, Jeong-Seok Nam, Changsun Choi, Jeong-Hwan Che, Ji- Youn Jung
Summary: This study found that Piperlongumine (PL) induces apoptosis in cervical cancer cells and demonstrated the relationship between apoptosis and autophagy. The anti-cancer effect of PL is mediated through inhibiting the PI3K/protein kinase B/mammalian target of rapamycin pathway, while inhibiting the PI3K pathway increases autophagy.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Zhaoqi Wang, Md Iqbal Hossain, Daseul Yeo, Seoyoung Woo, Yeeun Seo, Soontag Jung, Hyojin Kwon, Myeong-In Jeong, Changsun Choi
Summary: This study aimed to efficiently detect foodborne viruses by inoculating murine norovirus 1 (MNV-1) and hepatitis A virus (HAV) into post-washing water (PWW) containing various PCR inhibitors. The paper filtration-coupled ultrafiltration (PFC-UF) method combined with the OneStep PCR Inhibitor Removal Kit successfully recovered viruses from samples with high soil content and PCR inhibitors, providing a promising platform for foodborne virus surveillance in washing water.
Article
Food Science & Technology
Sun Min Park, Changsun Choi, Min Suk Rhee
Summary: This study developed a method to detect Coxiella burnetii in meat and successfully detected the pathogen in high and low contaminated meat samples. The method has the potential to reveal the risk of meat-borne Q fever in humans.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Sunho Park, Md Iqbal Hossain, Soontag Jung, Zhaoqi Wang, Daseul Yeo, Seoyoung Woo, Yeeun Seo, Myeong-In Jeong, Changsun Choi
Summary: Fresh root vegetables can be a potential reservoir for human pathogenic viruses, including adenovirus and norovirus. Prevalence of these viruses, as well as rotavirus, astrovirus, and hepatitis A virus, in pre- and post-washed root vegetables was investigated. Results showed that adenovirus and norovirus GII were only detected in pre-washed samples. Hepatitis A virus was detected in both pre- and post-washed sweet potatoes, while norovirus GI and astrovirus were not detected in any of the root vegetables. Further research is needed to confirm the hypothesis that root vegetables can serve as a potential source of viral foodborne diseases. Washing produce can help reduce the risk of contracting diseases from certain root vegetables.
