Microglial SIRPα Deletion Facilitates Synapse Loss in Preclinical Models of Neurodegeneration

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

(2021) Xin Ding et al.   Nature Communications

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

(2020) Nicole Scott‐Hewitt et al.   EMBO JOURNAL

Core Concept: How synaptic pruning shapes neural wiring during development and, possibly, in disease

(2020) Jill Sakai   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

(2020) Tim Bartels et al.   SCIENCE

Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders

(2020) Alexia Duveau et al.   Neuroscience Bulletin

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

(2019) Carl M. Sellgren et al.   NATURE NEUROSCIENCE

Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation

(2019) Francesca Grassivaro et al.   JOURNAL OF NEUROSCIENCE

A ‘don’t eat me’ immune signal protects neuronal connections

(2018) Serge Rivest   NATURE

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

(2018) Emily K. Lehrman et al.   NEURON

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

SIRP/CD47 signaling in neurological disorders

(2015) Haiyue Zhang et al.   BRAIN RESEARCH