Chitooligosaccharides alleviate hepatic fibrosis by regulating the polarization of M1 and M2 macrophages

Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study

(2020) Vlad Ratziu et al.   HEPATOLOGY

Macrophage Polarization Mediated by Chitooligosaccharide (COS) and Associated Osteogenic and Angiogenic Activities

(2020) Xiuhong Huang et al.   ACS Biomaterials-Science & Engineering

Immunostimulatory Effects of Chitooligosaccharides on RAW 264.7 Mouse Macrophages via Regulation of the MAPK and PI3K/Akt Signaling Pathways

(2019) Yue Yang et al.   Marine Drugs

rhIL-1Ra reduces hepatocellular apoptosis in mice with acute liver failure mainly by inhibiting the activities of Kupffer cells

(2019) Xiaolan Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Stemona alkaloids suppress the positive feedback loop between M2 polarization and fibroblast differentiation by inhibiting JAK2/STAT3 pathway in fibroblasts and CXCR4/PI3K/AKT1 pathway in macrophages

(2019) Qi Ding et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem

(2019) Bolin Jing et al.   Marine Drugs

Chitooligosaccharide supplementation prevents the development of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice via the inhibition of cluster of differentiation 36 (CD36)

(2019) Mengyao Zhao et al.   Journal of Functional Foods

A novel deactivation factor of fibrogenic hepatic stellate cells induces regression of liver fibrosis in mice

(2019) Yasuhiro Nakano et al.   HEPATOLOGY

Pathogenic and Therapeutic Relevance of JAK/STAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent

(2019) Alessia Alunno et al.   Cells

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases

(2019) Daphne van der Heide et al.   Frontiers in Immunology

Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice

(2018) Junping Zheng et al.   CARBOHYDRATE POLYMERS

Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases

(2018) Zhaoqi Yan et al.   CLINICAL IMMUNOLOGY

Kupffer-derived matrix metalloproteinase-9 contributes to liver fibrosis resolution

(2018) Min Feng et al.   International Journal of Biological Sciences

Erythropoietin alleviates hyperglycaemia-associated inflammation by regulating macrophage polarization via the JAK2/STAT3 signalling pathway

(2018) Jinjin Cui et al.   MOLECULAR IMMUNOLOGY

S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis

(2018) Wei Zhang et al.   Frontiers in Immunology

Physalin D regulates macrophage M1/M2 polarization via the STAT1/6 pathway

(2018) Ning Ding et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

(2017) Rohit Loomba et al.   HEPATOLOGY

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice

(2017) Peng-Fei Ma et al.   JOURNAL OF HEPATOLOGY

Macrophage Phenotype in Liver Injury and Repair

(2017) Y.-Y. Sun et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Liver Fibrosis: From Pathogenesis to Novel Therapies

(2016) Ralf Weiskirchen et al.   DIGESTIVE DISEASES

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

The effect of chitooligosaccharides on oleic acid-induced lipid accumulation in HepG 2 cells

(2016) Peiqiu Cao et al.   SAUDI PHARMACEUTICAL JOURNAL

Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration

(2015) Amitava Das et al.   AMERICAN JOURNAL OF PATHOLOGY

Pulmonary macrophages: key players in the innate defence of the airways

(2015) Adam J Byrne et al.   THORAX

Chitooligosaccharides from the shrimp chitosan hydrolysate induces differentiation of murine RAW264.7 macrophages into dendritic-like cells

(2015) Guan-James Wu et al.   Journal of Functional Foods

Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype

(2015) Igor Malyshev et al.   Biomed Research International

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis

(2014) Etty N. Benveniste et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis

(2014) Mark A. Barnes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chitooligosaccharides inhibit ethanol-induced oxidative stress via activation of Nrf2 and reduction of MAPK phosphorylation

(2014) ZHIGUO LUO et al.   ONCOLOGY REPORTS

Macrophage M1/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptococcus neoformans Infection

(2013) M. J. Davis et al.   mBio

Gallic acid-grafted chitooligosaccharides suppress antigen-induced allergic reactions in RBL-2H3 mast cells

(2012) Thanh-Sang Vo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages: Central regulators of hepatic fibrogenesis and fibrosis resolution

(2012) Prakash Ramachandran et al.   JOURNAL OF HEPATOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Chitooligosaccharide ameliorates diet-induced obesity in mice and affects adipose gene expression involved in adipogenesis and inflammation

(2012) Eun Hye Choi et al.   NUTRITION RESEARCH

Anethole Exerts Antimetatstaic Activity via Inhibition of Matrix Metalloproteinase 2/9 and AKT/Mitogen-Activated Kinase/Nuclear Factor Kappa B Signaling Pathways

(2011) Eun Jeong Choo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Characterization of polysaccharide from Astragalus radix as the macrophage stimulator

(2011) Lu-Hang Zhao et al.   CELLULAR IMMUNOLOGY

Proteome analysis in adipose tissue of ob/ob mice in response to chitosan oligosaccharides treatment

(2010) Md. Atiar Rahman et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Hepatoprotective effect of chitooligosaccharides against tert-butylhydroperoxide-induced damage in Chang liver cells

(2010) Mahinda Senevirathne et al.   CARBOHYDRATE POLYMERS

Inhibitory effects of chitooligosaccharides on degranulation and cytokine generation in rat basophilic leukemia RBL-2H3 cells

(2010) Thanh-Sang Vo et al.   CARBOHYDRATE POLYMERS