A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes

(2021) Joe R. Harman et al.   GENOME RESEARCH

Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia

(2020) Yuzhe Shi et al.   HAEMATOLOGICA

H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

(2020) Laura Godfrey et al.   LEUKEMIA

The molecular functions of common and atypical MLL fusion protein complexes

(2020) Satoshi Takahashi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A risk-stratified therapy for infants with acute lymphoblastic leukemia: a report from the JPLSG MLL-10 trial

(2020) Daisuke Tomizawa et al.   BLOOD

HOXA9/IRX1 expression pattern defines two sub-groups of infant MLL-AF4-driven Acute Lymphoblastic Leukemia

(2020) V. Symeonidou et al.   EXPERIMENTAL HEMATOLOGY

NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia

(2019) Belen Lopez-Millan et al.   LEUKEMIA

Unravelling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis

(2019) Antonio Agraz-Doblas et al.   HAEMATOLOGICA

Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study

(2019) Rob Pieters et al.   JOURNAL OF CLINICAL ONCOLOGY

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

(2019) Laura Godfrey et al.   Nature Communications

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

(2019) Sorcha O’Byrne et al.   BLOOD

RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1

(2019) Irina A. Elcheva et al.   LEUKEMIA

Genetic Basis of Acute Lymphoblastic Leukemia

(2017) Ilaria Iacobucci et al.   JOURNAL OF CLINICAL ONCOLOGY

The MLL recombinome of acute leukemias in 2017

(2017) C Meyer et al.   LEUKEMIA

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

(2017) Jon Kerry et al.   Cell Reports

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia

(2016) Shan Lin et al.   CANCER CELL

Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

(2016) M Ryan Corces et al.   NATURE GENETICS

The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism

(2016) Alessa Kühn et al.   Oncotarget

Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

(2016) Michael C. Gundry et al.   Cell Reports

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

(2015) Anna K Andersson et al.   NATURE GENETICS

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system

(2014) R. Torres et al.   Nature Communications

The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells

(2013) Michael R. Copley et al.   NATURE CELL BIOLOGY

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

(2012) A. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

The AF4{middle dot}MLL fusion protein is capable of inducing ALL in mice without requirement of MLL{middle dot}AF4

(2010) A. Bursen et al.   BLOOD

Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial

(2010) Anthony V Moorman et al.   LANCET ONCOLOGY

t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL

(2010) Ashish R. Kumar et al.   LEUKEMIA RESEARCH

Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

(2009) R. W. Stam et al.   BLOOD

Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients

(2009) Luca Trentin et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL