Network medicine for disease module identification and drug repurposing with the NeDRex platform

In Alzheimer Research, Glucose Metabolism Moves to Center Stage

(2020) Bridget M. Kuehn   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pitolisant for treating patients with narcolepsy

(2020) Shuang Li et al.   Expert Review of Clinical Pharmacology

Breaking Eroom’s Law

(2020) Michael S. Ringel et al.   NATURE REVIEWS DRUG DISCOVERY

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

(2020) Sepideh Sadegh et al.   Nature Communications

A phase II, single center, randomized, double‐blind, placebo‐controlled study of the safety and therapeutic effectiveness of intranasal glulisine in amnestic mild cognitive impairment and probable mild Alzheimer’s disease

(2020) Michael H. Rosenbloom et al.   Alzheimers & Dementia

BiCoN: Network-constrained biclustering of patients and omics data

(2020) Olga Lazareva et al.   BIOINFORMATICS

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

(2019) Uku Raudvere et al.   NUCLEIC ACIDS RESEARCH

α2-macroglobulin in Alzheimer's disease: new roles for an old chaperone

(2018) Sahba Seddighi et al.   Biomarkers in Medicine

The JAK inhibitor ruxolitinib reduces inflammation in an ILC3-independent model of innate immune colitis

(2018) A. M. Overstreet et al.   Mucosal Immunology

Associations of Anti-Hypertensive Treatments with Alzheimer's Disease, Vascular Dementia, and Other Dementias

(2018) Neil M. Davies et al.   JOURNAL OF ALZHEIMERS DISEASE

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

DrugCentral 2018: an update

(2018) Oleg Ursu et al.   NUCLEIC ACIDS RESEARCH

IID 2018 update: context-specific physical protein–protein interactions in human, model organisms and domesticated species

(2018) Max Kotlyar et al.   NUCLEIC ACIDS RESEARCH

OMIM.org: leveraging knowledge across phenotype–gene relationships

(2018) Joanna S Amberger et al.   NUCLEIC ACIDS RESEARCH

Rationale and Design of the Mechanistic Potential of Antihypertensives in Preclinical Alzheimer’s (HEART) Trial

(2017) Whitney Wharton et al.   JOURNAL OF ALZHEIMERS DISEASE

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Systematic integration of biomedical knowledge prioritizes drugs for repurposing

(2017) Daniel Scott Himmelstein et al.   eLife

A standard database for drug repositioning

(2017) Adam S. Brown et al.   Scientific Data

The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species

(2016) Christopher J. Mungall et al.   NUCLEIC ACIDS RESEARCH

Choline Metabolism Alteration: A Focus on Ovarian Cancer

(2016) Marina Bagnoli et al.   Frontiers in Oncology

The Syk Inhibitor Fostamatinib Decreases the Severity of Colonic Mucosal Damage in a Rodent Model of Colitis

(2015) Guray Can et al.   Journal of Crohns & Colitis

Uncovering disease-disease relationships through the incomplete interactome

(2015) J. Menche et al.   SCIENCE

A DIseAse MOdule Detection (DIAMOnD) Algorithm Derived from a Systematic Analysis of Connectivity Patterns of Disease Proteins in the Human Interactome

(2015) Susan Dina Ghiassian et al.   PLoS Computational Biology

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Correcting for the study bias associated with protein–protein interaction measurements reveals differences between protein degree distributions from different cancer types

(2015) Martin H. Schaefer et al.   Frontiers in Genetics

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

(2014) M. Yarchoan et al.   DIABETES

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of Progesterone in Oocyte Acquisition of Developmental Competence

(2012) T Fair et al.   REPRODUCTION IN DOMESTIC ANIMALS

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses

(2010) J. T. Tigno-Aranjuez et al.   GENES & DEVELOPMENT

Mechanisms of tumor resistance to EGFR-targeted therapies

(2009) Elizabeth A Hopper-Borge et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Lamotrigine in motor and mood symptoms of Huntington's disease

(2008) Yu-Chih Shen   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY