α2-macroglobulin in Alzheimer's disease: new roles for an old chaperone

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

SPARCL1 Accelerates Symptom Onset in Alzheimer’s Disease and Influences Brain Structure and Function During Aging

(2017) Sahba Seddighi et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin

(2016) Sandeep K. Singh et al.   CELL

Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway

(2016) V R Varma et al.   MOLECULAR PSYCHIATRY

α2-Macroglobulin

(2016) Jason M. Cuéllar et al.   Physical Medicine and Rehabilitation Clinics of North America

Current thinking on the mechanistic basis of Alzheimer's and implications for drug development

(2015) C Ising et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Regulation of GAP43/calmodulin complex formation via calcineurin-dependent mechanism in differentiated PC12 cells with altered PMCA isoforms composition

(2015) Tomasz Boczek et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Alzheimer disease therapeutics: Focus on the disease and not just plaques and tangles

(2014) Khalid Iqbal et al.   BIOCHEMICAL PHARMACOLOGY

Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17

(2014) B Mojsa et al.   CELL DEATH AND DIFFERENTIATION

Hypochlorite-induced structural modifications enhance the chaperone activity of human  2-macroglobulin

(2014) A. R. Wyatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress

(2014) J M van der Harg et al.   Cell Death & Disease

Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease

(2014) Emma V. Jones et al.   NEURAL PLASTICITY

Identification of α2-Macroglobulin as a Master Inhibitor of Cartilage-Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis

(2014) Shaowei Wang et al.   Arthritis & Rheumatology

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

(2013) Amy R. Wyatt et al.   FEBS LETTERS

The Early Involvement of the Innate Immunity in the Pathogenesis of Lateonset Alzheimers Disease: Neuropathological, Epidemiological and Genetic Evidence

(2012) P. Eikelenboom et al.   Current Alzheimer Research

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

(2011) Diana AT Nijholt et al.   JOURNAL OF PATHOLOGY

Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

(2011) Hakan Kucukdereli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is Alzheimer's Disease a Result of Presynaptic Failure? - Synaptic Dysfunctions Induced by Oligomeric β-Amyloid

(2011) Volker Nimmrich et al.   REVIEWS IN THE NEUROSCIENCES

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease

(2010) Madhav Thambisetty et al.   ARCHIVES OF GENERAL PSYCHIATRY

Do extracellular chaperone proteins in plasma have potential as Alzheimer’s disease biomarkers?

(2010) Madhav Thambisetty   Biomarkers in Medicine

Molecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammation

(2010) Brian Henderson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Amyloid-β Oligomers: Possible Roles as Key Neurotoxins in Alzheimer's Disease

(2010) Alex L. Lublin et al.   MOUNT SINAI JOURNAL OF MEDICINE

Extracellular chaperones modulate the effects of Alzheimer’s patient cerebrospinal fluid on Aβ1-42 toxicity and uptake

(2009) Justin J. Yerbury et al.   CELL STRESS & CHAPERONES

Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component

(2009) S. E. Kolstoe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of astrocyte-secreted matricellular proteins in central nervous system development and function

(2009) Cagla Eroglu   Journal of Cell Communication and Signaling

Protease Activation of α2-Macroglobulin Modulates a Chaperone-like Action with Broad Specificity

(2008) Katie French et al.   BIOCHEMISTRY

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity

(2007) Mark R. Wilson et al.   Molecular BioSystems