Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia
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Title
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia
Authors
Keywords
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Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-11-08
DOI
10.1038/s41467-021-26683-0
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Note: Only part of the references are listed.- 5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.
- (2020) Sha Jin et al. CLINICAL CANCER RESEARCH
- CD28/4-1BB CD123 CAR T cells in blastic plasmacytoid dendritic cell neoplasm
- (2020) Elodie Bôle-Richard et al. LEUKEMIA
- Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease
- (2020) Robert Zeiser et al. NEW ENGLAND JOURNAL OF MEDICINE
- Case Report of Anti-CD123 Chimeric Antigen Receptor T-Cell Therapy Followed by Radiotherapy for a Recurrence of Blastic Plasmacytoid Dendritic Cell Neoplasm After Allogeneic Hematopoietic Stem Cell Transplantation
- (2020) Yi-li Jiang et al. OncoTargets and Therapy
- CAR T Cells for Acute Myeloid Leukemia: State of the Art and Future Directions
- (2020) Sherly Mardiana et al. Frontiers in Oncology
- Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function
- (2020) Frederike A. Hartl et al. NATURE IMMUNOLOGY
- Inefficient CAR-proximal signaling blunts antigen sensitivity
- (2020) Venugopal Gudipati et al. NATURE IMMUNOLOGY
- 41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo
- (2020) Matteo Libero Baroni et al. Journal for ImmunoTherapy of Cancer
- Chimeric Antigen Receptor T Cell Exhaustion during Treatment for Hematological Malignancies
- (2020) Chunyi Shen et al. Biomed Research International
- An immunoproteomic approach to characterize the CAR interactome and signalosome
- (2019) Maria C. Ramello et al. Science Signaling
- How I treat acute myeloid leukemia in the era of new drugs
- (2019) Courtney D. DiNardo et al. BLOOD
- DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance
- (2019) Katsuhiro Togami et al. JOURNAL OF CLINICAL INVESTIGATION
- Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
- (2018) Nimitha R Mathew et al. NATURE MEDICINE
- Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML
- (2018) Courtney D. DiNardo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia
- (2018) Jae H. Park et al. NEW ENGLAND JOURNAL OF MEDICINE
- 5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox
- (2018) Fabian Müller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia
- (2018) Elena J. Orlando et al. NATURE MEDICINE
- Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function
- (2018) Alexander I. Salter et al. Science Signaling
- Mechanisms of immune escape after allogeneic hematopoietic cell transplantation
- (2018) Robert Zeiser et al. BLOOD
- Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Non-randomized, Open-label, Phase 2 Study
- (2018) Naval Daver et al. Cancer Discovery
- Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia
- (2017) Mingxue Fan et al. Journal of Hematology & Oncology
- A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization
- (2017) Esther Drent et al. MOLECULAR THERAPY
- Immunology: The chronicles of T-cell exhaustion
- (2017) Robert A. Amezquita et al. NATURE
- Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity
- (2017) Arnab Ghosh et al. NATURE MEDICINE
- Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy
- (2017) Robert Zeiser et al. NEW ENGLAND JOURNAL OF MEDICINE
- Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
- (2017) Richard M. Stone et al. NEW ENGLAND JOURNAL OF MEDICINE
- Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice
- (2016) Y. Saito et al. BLOOD
- Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
- (2016) Hartmut Döhner et al. BLOOD
- Clinical Impact of Hypomethylating Agents in the Treatment of Myelodysplastic Syndromes
- (2016) Carlo Finelli et al. CURRENT PHARMACEUTICAL DESIGN
- deepTools2: a next generation web server for deep-sequencing data analysis
- (2016) Fidel Ramírez et al. NUCLEIC ACIDS RESEARCH
- The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update
- (2016) Enis Afgan et al. NUCLEIC ACIDS RESEARCH
- 5-Azacytidine and DLI can induce long-term remissions in AML patients relapsed after allograft
- (2015) J Steinmann et al. BONE MARROW TRANSPLANTATION
- DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
- (2015) David Roulois et al. CELL
- Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
- (2015) Katherine B. Chiappinelli et al. CELL
- Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells
- (2014) S. Gill et al. BLOOD
- Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC
- (2014) S J Busfield et al. LEUKEMIA
- 5-Azacytidine enhances the anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia
- (2014) May Kung Sutherland et al. mAbs
- 5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity
- (2014) Thomas Stübig et al. MEDIATORS OF INFLAMMATION
- Development and function of human innate immune cells in a humanized mouse model
- (2014) Anthony Rongvaux et al. NATURE BIOTECHNOLOGY
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- 5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies
- (2014) A O Gang et al. Blood Cancer Journal
- Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody
- (2014) Sophie E. Broughton et al. Cell Reports
- T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia
- (2013) A. Mardiros et al. BLOOD
- Azacitidine and donor lymphocyte infusions as first salvage therapy for relapse of AML or MDS after allogeneic stem cell transplantation
- (2013) T Schroeder et al. LEUKEMIA
- Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents
- (2013) H Yang et al. LEUKEMIA
- Identification of active regulatory regions from DNA methylation data
- (2013) Lukas Burger et al. NUCLEIC ACIDS RESEARCH
- Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia
- (2012) C Craddock et al. LEUKEMIA
- Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia
- (2010) O. Goodyear et al. BLOOD
- T-cell exhaustion: characteristics, causes and conversion
- (2010) John S. Yi et al. IMMUNOLOGY
- A Comparison of Azacitidine and Decitabine Activities in Acute Myeloid Leukemia Cell Lines
- (2010) Paul W. Hollenbach et al. PLoS One
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
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