BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate

Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2

(2021) Michael G. Yang et al.   ACS Medicinal Chemistry Letters

Targeting CCR2/5 in the treatment of nonalcoholic steatohepatitis (NASH) and fibrosis: opportunities and challenges

(2020) Sander Lefere et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The multilayered complexity of the chemokine receptor system

(2020) Gianluca D’Agostino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Use of a conformational switching mechanism to modulate exposed polarity: discovery of CCR2 antagonist BMS-741672

(2019) Michael G. Yang et al.   ACS Medicinal Chemistry Letters

Recent Advances targeting CCR5 for Cancer and its Role in Immuno-Oncology

(2019) Xuanmao Jiao et al.   CANCER RESEARCH

Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders

(2019) Laura Fantuzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor

(2019) Bao-Hua Li et al.   MOLECULAR IMMUNOLOGY

The regulation and importance of monocyte chemoattractant protein-1

(2018) Vanessa Bianconi et al.   CURRENT OPINION IN HEMATOLOGY

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

Modulating Macrophage Polarization through CCR2 Inhibition and Multivalent Engagement

(2018) Michael B. Deci et al.   MOLECULAR PHARMACEUTICS

The Expanding Therapeutic Perspective of CCR5 Blockade

(2018) Luca Vangelista et al.   Frontiers in Immunology

The role of CCR5 in directing the mobilization and biological function of CD11b+Gr1+Ly6Clow polymorphonuclear myeloid cells in cancer

(2018) Nathan Karin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

(2018) Julie G Grossman et al.   OncoImmunology

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

(2016) Yi Zheng et al.   NATURE

Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis

(2016) Eric Lefebvre et al.   PLoS One

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Site-Specific Chemokine Expression Regulates Central Nervous System Inflammation and Determines Clinical Phenotype in Autoimmune Encephalomyelitis

(2014) Joshua S. Stoolman et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis

(2013) D. E. Sanford et al.   CLINICAL CANCER RESEARCH

Progress in the discovery of CC chemokine receptor 2 antagonists, 2009 – 2012

(2013) Percy H Carter   EXPERT OPINION ON THERAPEUTIC PATENTS

Small Molecule Antagonists of the Chemokine Receptor CCR5

(2010) Remy C. Lemoine et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases

(2010) Qihong Zhao   JOURNAL OF LEUKOCYTE BIOLOGY

The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases

(2010) Grégory Conductier et al.   JOURNAL OF NEUROIMMUNOLOGY

Overcoming Undesirable hERG Potency of Chemokine Receptor Antagonists Using Baseline Lipophilicity Relationships

(2008) Igor Shamovsky et al.   JOURNAL OF MEDICINAL CHEMISTRY