Article
Environmental Sciences
Zhibing Liu, Jinru Ma, Xulei Zuo, Xuesong Zhang, Yiting Hong, Shuyang Cai, Hua Huang, Feng Wang, Changhao Wu, Jiaxiang Zhang, Qixing Zhu
Summary: The study aims to explore renal tubular ferroptosis induced by trichloroethylene sensitization and its mechanism. Through observation of the kidneys of trichloroethylene-sensitized mice and HK-2 cells, it was found that C5b-9 and cytosolic Ca2+ overload may play a key role in renal tubular ferroptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Kurt T. K. Giuliani, Anca Grivei, Purba Nag, Xiangju Wang, Melissa Rist, Katrina Kildey, Becker Law, Monica S. Ng, Ray Wilkinson, Jacobus Ungerer, Josephine M. Forbes, Helen Healy, Andrew J. Kassianos
Summary: This study identifies ferroptosis as the primary pattern of PTEC necrosis under the hypoxic conditions of CKD and establishes NLRP3 inflammasome signalling driven by complex tubulointerstitial PTEC-DC interactions as a key checkpoint for therapeutic targeting in human CKD.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Qian-lin Tan, Ming-xia Zhang, Deng-hu Yao, Yue Yan, Xiao-fen Yang, Zhi-hui Qin, Yan Gong, Qiao Meng
Summary: This study explored the potential biological significance and underlying mechanism of TIGAR in modulating adenine-induced ferroptosis in human proximal tubular epithelial cells. The results showed that TIGAR overexpression repressed adenine-induced ferroptosis and activated the mTOR/S6KP70 signaling pathway. Therefore, activating the TIGAR/mTOR/S6KP70 axis may be a treatment for crystal nephropathies.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Chien-Hung Lin, Chuan Wan, Wen-Sheng Liu, Hsin-Hui Wang
Summary: Exposure to PM2.5 can induce EMT characteristics in HK-2 cells, with the IL-6/STAT3 pathway playing a key role in mediating early renal tubule cell injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Timo N. Haschler, Harry Horsley, Monika Balys, Glenn Anderson, Jan-Willem Taanman, Robert J. Unwin, Jill T. Norman
Summary: SIRT5 plays a critical role in ischemic renal injury, with its depletion affecting mitochondrial function in murine and human proximal tubular epithelial cells.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Alexandra Linke, Hakan Cicek, Anne Mueller, Catherine Meyer-Schwesinger, Simon Melderis, Thorsten Wiech, Claudia Wegscheid, Julius Ridder, Oliver M. Steinmetz, Linda Diehl, Gisa Tiegs, Katrin Neumann
Summary: This study found that proximal tubular epithelial cells (PTECs) have the capacity for antigen cross-presentation, which can modulate the immune response in immune-mediated glomerular diseases, such as lupus nephritis.
Article
Biochemistry & Molecular Biology
Miyeon Kim, Ju Young Bae, Soyeon Yoo, Hyun Woo Kim, Sang Ah Lee, Eui Tae Kim, Gwanpyo Koh
Summary: The study found that 2-deoxy-D-ribose (dRib) induces ferroptosis in renal tubular epithelial cells by degrading xCT protein through the ubiquitin-proteasome system, resulting in reduced cystine uptake.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Zhenling Deng, Ziyang Jing, Yanhong Guo, Junfan Ma, Huige Yan, Zhan Shi, Hui Deng, Yaoxian Liang, Song Wang, Zhuan Cui, Yuejuan Pan, Xiaoyan Qiu, Yue Wang
Summary: The study found that proximal tubular epithelial cells may express IgG in a similar manner to B cells, and that IgG expression is upregulated by TGF-beta 1, potentially playing a role in epithelial-mesenchymal transition.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Virology
Zongsong Wu, Fabrice E. Graf, Hans H. Hirsch
Summary: The study demonstrates that acitretin selectively inhibits BK polyomavirus replication in primary human cells, suggesting its potential use for treating BK polyomavirus-associated diseases such as nephropathy and hemorrhagic cystitis. Further research is needed to explore the clinical repurposing of retinoids for these conditions.
JOURNAL OF VIROLOGY
(2021)
Article
Food Science & Technology
Johanna Detzner, Anna-Lena Klein, Gottfried Pohlentz, Elisabeth Krojnewski, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Muething
Summary: The study highlights the significant role of tubular epithelial cells of the human kidney in the pathogenesis of hemolytic-uremic syndrome caused by enterohemorrhagic Escherichia coli, particularly in the case of Stx1a. The investigation shows that Stx1a exerts higher cellular cytotoxicity and stronger binding capability compared to Stx2a, indicating differences in their impact on cell damage.
Article
Pharmacology & Pharmacy
Yan Li, Ke Li, Weihao Zhao, Haodong Wang, Xiaodong Xue, Xianghui Chen, Wantao Li, Peihao Xu, Kexin Wang, Pengfei Liu, Xuefei Tian, Rongguo Fu
Summary: This study found that valproic acid (VPA) prevents cisplatin-induced renal injury through regulating glutathione peroxidase 4 (GPX4) and inhibiting ferroptosis. This suggests that inhibiting ferroptosis through VPA is a viable treatment for cisplatin-induced acute kidney injury.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Pingwei Wang, Dongge Liu, Shuqi Yan, Yujun Liang, Jiajing Cui, Li Guo, Shuping Ren, Peng Chen
Summary: This study demonstrates for the first time that PFOS induces ferroptosis in HK-2 cells. Additionally, the involvement of endoplasmic reticulum stress, apoptotic mechanism, and P53-mediated antioxidant mechanism in PFOS-induced cytotoxic damage are explored. These findings provide new insights into the toxicity of PFOS and its impact on kidney damage and mechanisms.
Article
Cell Biology
Xiangju Wang, Ray Wilkinson, Katrina Kildey, Jacobus P. J. Ungerer, Michelle M. Hill, Alok K. Shah, Ahmed Mohamed, Mriga Dutt, Jeffrey Molendijk, Helen Healy, Andrew J. Kassianos
Summary: Proximal tubular epithelial cells play a central role in inflammatory kidney diseases, with the secretion of sEV involved in disease progression. The molecular composition of sEV released from the apical versus basolateral membranes under inflammatory conditions differs, suggesting specialized functional roles for each.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Immunology
Zhi Zhao, Guoli Li, Yuxi Wang, Yinzheng Li, Huzi Xu, Wei Liu, Wenke Hao, Ying Yao, Rui Zeng
Summary: In this study, it was demonstrated that cytosolic HMGB1 induces ferroptosis by binding to ACSL4, exacerbating cellular injury in acute kidney injury (AKI). Inhibition of HMGB1 nucleocytoplasmic translocation and deletion of HMGB1 in tubular epithelial cells reduced AKI, tubular ferroptosis, and inflammation in mice. Co-immunoprecipitation and serial section staining confirmed the interaction between HMGB1 and ACSL4. These findings suggest that cytoplasmic HMGB1 is a regulator of ferroptosis and a promising therapeutic target for AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Jennifer Eymael, Brigith Willemsen, Joyce Xu, Fieke Mooren, Eric Steenbergen, Jack F. Wetzels, Henry Dijkman, Jitske Jansen, Johan van der Vlag, Bart Smeets
Summary: Multiple motile cilia with a central microtubular pair were found in kidney biopsies of patients with kidney diseases, and these cells were associated with tubular injury and interstitial fibrosis. This suggests the ability of proximal tubular cells to transdifferentiate into multiciliated cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Andrew Jeyaruban, Wendy Hoy, Anne L. Cameron, Helen G. Healy, Zaimin Wang, Jenny Zhang, Andrew Mallett
Summary: This study found that intervention for IHD in CKD patients was associated with increased survival but did not result in changes in renal disease progression when compared to medically managed patients.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Urology & Nephrology
Robert J. Ellis, Anne Cameron, Glenda C. Gobe, Vishal Diwan, Helen G. Healy, Jeremy Lee, Ken-Soon Tan, Sree Venuthurupalli, Jianzhen Zhang, Wendy E. Hoy
Summary: This study aimed to examine whether the progression of chronic kidney disease (CKD) differs between patients whose primary cause of CKD was nephrectomy and those with non-surgical causes. Results indicated that CKD after nephrectomy had similar rates of adverse events to most other causes of CKD, except for diabetic nephropathy which was consistently associated with worse outcomes.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Letter
Urology & Nephrology
Joel P. Russell, Helen Healy, Leo Francis, Julia Jefferis
Letter
Urology & Nephrology
Julia Jefferis, Andrew J. Kassianos, Anca Grivei, Brian Doucet, Helen Healy, Leo Francis, Saw Yu Mon, George T. John
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Andrew Mallett, Phoebe Jane Kearey, Anne Cameron, Helen G. Healy, Charles Denaro, Mark Thomas, Vincent W. Lee, Samantha Louise Stark, Maria Fuller, Zaimin Wang, Wendy E. Hoy
Summary: The study found a prevalence rate of 0.2% for Fabry disease among CKD patients. Using a multi-tiered screening strategy, cases of FD can be identified in the CKD population.
Article
Medicine, General & Internal
Arti M. Raghubar, Duy T. Pham, Xiao Tan, Laura F. Grice, Joanna Crawford, Pui Yeng Lam, Stacey B. Andersen, Sohye Yoon, Siok Min Teoh, Nicholas A. Matigian, Anne Stewart, Leo Francis, Monica S. Y. Ng, Helen G. Healy, Alexander N. Combes, Andrew J. Kassianos, Quan Nguyen, Andrew J. Mallett
Summary: This study applied spatial transcriptomics sequencing (ST-seq) to investigate the gene expression patterns in the kidneys of mice and humans. The results revealed the gene expression signatures of different nephron structures and microvascular regions, and identified potential ligand-receptor interactions in specific areas of the kidneys. The study provides valuable insights into the complexity of kidney physiology and serves as a valuable resource for future research in this field.
FRONTIERS IN MEDICINE
(2022)
Article
Medical Laboratory Technology
Carla Scuderi, Suzanne Parker, Margaret Jacks, George T. John, Brett McWhinney, Jacobus Ungerer, Andrew Mallett, Helen Healy, Jason Roberts, Christine Staatz
Summary: This study examined microsampling approaches for the simultaneous measurement of immunosuppressant drug concentrations in kidney transplant patients. The results showed that VAMS was more accurate than DBS in measuring the drug concentrations.
THERAPEUTIC DRUG MONITORING
(2023)
Article
Urology & Nephrology
Carla E. Scuderi, Suzanne L. Parker, Margaret Jacks, George T. John, Brett McWhinney, Jacobus Ungerer, Andrew J. Mallett, Helen G. Healy, Jason A. Roberts, Christine E. Staatz
Summary: This study aimed to assess the diagnostic accuracy of using volumetric absorptive microsamplers (VAMS) to measure tacrolimus and creatinine in kidney transplant recipients. The results showed that VAMS can reliably measure tacrolimus and creatinine, providing a less invasive and more frequent sampling method for patients.
Article
Urology & Nephrology
Jianzhen Zhang, Vishal Diwan, Zaimin Wang, Helen G. Healy, Sree Krishna Venuthurupalli, Rajitha Abeysekera, Wendy E. Hoy
Summary: This study explores the impact of anemia on patients with chronic kidney disease (CKD), and found that anemia is associated with increased rates of cardiovascular events, progression to kidney replacement therapy, and death. Additionally, anemia leads to higher hospital utilization and costs. Therefore, preventing and treating anemia is crucial for improving clinical and economic outcomes in CKD patients.
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Vishal Diwan, Jenny Zhang, Zaimin Wang, Helen Healy, Wendy Hoy
Review
Integrative & Complementary Medicine
Muhammad Ali Khan, Andrew J. Kassianos, Wendy E. Hoy, Ahm Khurshid Alam, Helen G. Healy, Glenda C. Gobe
Summary: Chronic kidney disease is a serious global health issue, and current therapies only delay its progression. This review explores the potential of using plant-based therapies to prevent and treat CKD. Many plants have antioxidant properties that can improve kidney function, and pre-clinical and in vivo studies have shown promising therapeutic benefits. Combining plant extracts with conventional therapies may have additive renoprotective effects. Further research is needed to rigorously test and optimize the therapeutic potential of medicinal plants.
JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE
(2022)