Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses

Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2

(2021) Michal Stefanik et al.   Microorganisms

Lignans and Their Derivatives from Plants as Antivirals

(2020) Qinghua Cui et al.   MOLECULES

Cleistanthin A inhibits the invasion of MDA-MB-231 human breast cancer cells: involvement of the β-catenin pathway

(2020) Siyuan Liu et al.   Pharmacological Reports

Selective Targeting of Virus Replication by Proton Pump Inhibitors

(2020) Susan M. Watanabe et al.   Scientific Reports

New cyclopeptide alkaloids from the whole plant of Justicia procumbens L

(2020) Jin-Peng Lv et al.   NATURAL PRODUCT RESEARCH

Antibacterial and antibiofilm activities of diphyllin against fish pathogens

(2020) Suman Thamburaj et al.   MICROBIAL PATHOGENESIS

Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus

(2019) Alicia Martinez-Lopez et al.   EBioMedicine

Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells

(2018) Haijiao Chen et al.   ONCOLOGY REPORTS

A Synthetic Disaccharide Derivative of Diphyllin, TAARD, Activates Human Natural Killer Cells to Secrete Interferon-Gamma via Toll-Like Receptor-Mediated NF-κB and STAT3 Signaling Pathways

(2018) Long Yi et al.   Frontiers in Immunology

Combined In Vitro Studies and in Silico Target Fishing for the Evaluation of the Biological Activities of Diphylleia cymosa and Podophyllum hexandrum

(2018) Marina Rocha et al.   MOLECULES

Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa

(2017) Hong-Jie Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Anti-HIV diphyllin glycosides from Justicia gendarussa

(2017) Hong-Jie Zhang et al.   PHYTOCHEMISTRY

Cleistanthin A inhibits the invasion and metastasis of human melanoma cells by inhibiting the expression of matrix metallopeptidase‑2 and ‑9

(2017) Sheng Pan et al.   Oncology Letters

Differential modulation of Bax/Bcl-2 ratio and onset of caspase-3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375

(2017) Aljawharah Al-Qathama et al.   Oncotarget

Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus

(2017) Che-Ming Jack Hu et al.   Scientific Reports

ZT-25, a new vacuolar H+-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells

(2016) Yapeng Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fusion of Enveloped Viruses in Endosomes

(2016) Judith M. White et al.   TRAFFIC

Arylnaphthalene and aryltetralin-type lignans in hairy root cultures ofLinum perenne, and the stereochemistry of 6-methoxypodophyllotoxin and one diastereoisomer by HPLC-MS and NMR spectroscopy

(2015) Nathalie Jullian-Pawlicki et al.   PHYTOCHEMICAL ANALYSIS

Synthesis, biological evaluation and molecular modeling of 1H-benzo[d]imidazole derivatives as novel anti-tubulin polymerization agents

(2015) Fang Wang et al.   RSC Advances

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

(2015) Yong-Bo Hu et al.   Translational Neurodegeneration

Synthesis and identification of cytotoxic diphyllin glycosides as vacuolar H+-ATPase inhibitors

(2014) Zhitao Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses

(2013) Hui-Wen Chen et al.   ANTIVIRAL RESEARCH

Entry of human rhinovirus 89 via ICAM-1 into HeLa epithelial cells is inhibited by actin skeleton disruption and by bafilomycin

(2013) Beatrix Pfanzagl et al.   ARCHIVES OF VIROLOGY

Synthesis and Bioevaluation of Diphyllin Glycosides as Novel Anticancer Agents

(2012) Yu Zhao et al.   ARCHIV DER PHARMAZIE

The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections

(2011) Konstantin H Müller et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of diphyllin as a novel V-ATPase inhibitor on gastric adenocarcinoma

(2011) Weidong Shen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

D11, a novel glycosylated diphyllin derivative, exhibits potent anticancer activity by targeting topoisomerase IIα

(2010) Min Gui et al.   INVESTIGATIONAL NEW DRUGS

Arylnaphthalene lignans from Taiwania cryptomerioides as novel blockers of voltage-gated K+ channels

(2010) Yuk-Man Leung et al.   PHYTOMEDICINE

V-ATPase inhibitors and implication in cancer treatment

(2009) Mario Pérez-Sayáns et al.   CANCER TREATMENT REVIEWS

Morphological changes in human neural cells following tick-borne encephalitis virus infection

(2009) D. Ruzek et al.   JOURNAL OF GENERAL VIROLOGY

The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection

(2009) Sarah A Dabydeen et al.   Virology Journal

Function, structure and regulation of the vacuolar (H+)-ATPases

(2008) Kevin C. Jefferies et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS