Article
Oncology
Junwei Xiang, Yaodong He, Yunshan Li, Kexuan Wu, Mengxiang Cheng, Yuanyin Wang, Ran Chen
Summary: In this study, a risk assessment model consisting of 14 hrlncRNA pairs was constructed for predicting and guiding the prognosis and treatment of HNSCC patients. High-risk patients had unfavorable prognosis and significant differences in TMB and tumor immune infiltration compared to the low-risk group. The model has potential clinical applications.
Article
Oncology
Yongwei Chen, Yanyun Zhu, Yuanmei Dong, Huizi Li, Chumeng Gao, Guoqiang Zhu, Xiao Mi, Chengcheng Li, Yu Xu, Guoqiang Wang, Shangli Cai, Yusheng Han, Chunwei Xu, Wenxian Wang, Shizhong Yang, Wenbin Ji
Summary: In this study, a prognostic signature of 24 genes based on pyroptosis clusters was established for HCC patients. The high-risk group showed lower overall survival compared to the low-risk group. Additionally, the expression of the model genes was correlated with immune cell infiltration, angiogenesis-related genes, and sensitivity to antiangiogenic therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Shuang Liu, Ruonan Shao, Xiaoyun Bu, Yujie Xu, Ming Shi
Summary: This study identified pyroptosis-related genes as predictors for prognosis of HCC patients and targeting pyroptosis as a potential therapeutic alternative in HCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Wenying Zhu, Zhipeng Ye, Ling Chen, Haifeng Liang, Qian Cai
Summary: This study identified a potential clinical value of pyroptosis-related long non-coding RNAs in head and neck squamous cell carcinoma. The lncRNA signature consisting of 14 pyroptosis-related long non-coding RNAs could serve as a prognostic marker for HNSCC, suggesting pyroptosis as a promising therapeutic target in this type of cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Zeng-Hong Wu, Zi-Wei Li, Dong-Liang Yang, Jia Liu
Summary: The study found that pyroptosis-related lncRNAs may have an impact on the tumor microenvironment in hepatocellular carcinoma, suggesting potential clinical applications in identifying novel biomarkers and predicting prognosis for patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Aimin Jiang, Jialin Meng, Yewei Bao, Anbang Wang, Wenliang Gong, Xinxin Gan, Jie Wang, Yi Bao, Zhenjie Wu, Juan Lu, Bing Liu, Linhui Wang
Summary: The study identified two heterogeneous pyroptosis subtypes and constructed a prognosis prediction model based on pyroptosis signatures. The high pyroptosis and high immunity subtype was associated with worse prognosis in clear cell renal cell carcinoma (ccRCC), highlighting the potential role of pyroptosis in the progression of ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Jie Zhou, Run-cong Nie, Yi-xin Yin, Yun Wang, Shu-qiang Yuan, Zi-han Zhao, Xin-ke Zhang, Jin-ling Duan, Ying-bo Chen, Zhi-wei Zhou, Dan Xie, Yuan-fang Li, Mu-yan Cai
Summary: This study investigates the relationship between pyroptosis and the tumor immune microenvironment (TIME) in gastric cancer. It identifies distinct clusters based on pyroptosis and constructs a risk scoring system. The low-pyroptosis risk score is associated with better immune cell fractions, higher MSI status, and increased response to immunotherapy. The study highlights the importance of the interaction between pyroptosis and TIME in gastric cancer, and the potential of the risk scoring system in predicting survival and response to immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Qiang Wang, Chengxin Chen, Kun Cao, Haiyang Li
Summary: By identifying differentially expressed pyroptosis-related genes and constructing a gene signature, this study established an effective prognostic tool for predicting the survival of hepatocellular carcinoma patients. The gene signature was validated externally and showed potential relationships between pyroptosis, complement, and immunity in HCC.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Min Deng, Shiquan Sun, Rongce Zhao, Renguo Guan, Zhen Zhang, Shaohua Li, Wei Wei, Rongping Guo
Summary: This study investigates the expression levels of pyroptosis-related genes in hepatocellular carcinoma (HCC) and their relationship with prognosis. A 10-gene signature was constructed to classify HCC patients into low-risk and high-risk groups, and the results showed that the low-risk group had significantly better survival rates. PRGs play a significant role in tumor immunity and have the potential to predict the prognosis of HCC patients.
MOLECULAR MEDICINE
(2022)
Article
Oncology
Chunyan Zhang, Jie Bai, Yu Yang, Xiaojuan Wang, Wanqiu Liu, Shujuan Hou, Zhongwei Ai, Qingling Xia, Lei Shao
Summary: This study assessed the expression of pyroptosis-related genes and their relationship with prognosis in uterine corpus endometrial carcinoma (UCEC). Two subtypes of UCEC were identified based on differentially expressed genes, and a multigene model was constructed. The results showed that UCEC cases with higher risk had a higher survival rate, and this was associated with the expression of specific genes.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Bin Chen, Yuanbo Luo, Xueran Kang, Yuxing Sun, Chenyan Jiang, Bin Yi, Xiaojun Yan, Yisheng Chen, Runjie Shi
Summary: This study aimed to understand the prognosis of patients with head and neck squamous cell carcinoma (HNSCC) and developed a prognostic model based on pyroptosis-associated genes (PAGs) in nasopharyngeal carcinoma. The results demonstrated that the developed model served as an independent risk factor for HNSCC, providing useful information for predicting patient survival.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Yaodong He, Yunshan Li, Junwei Xiang, Xu Huang, Mingyu Zhao, Yuanyin Wang, Ran Chen
Summary: Tyrosine kinase 2 (TYK2) is overexpressed in head and neck squamous cell carcinoma (HNSCC) and is associated with tumor growth, prognosis, and immune infiltration. TYK2 can serve as a novel biomarker for assessing the prognosis of HNSCC patients and aiding in immunotherapy against HNSCC.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Shixian Liu, Weiwei Liu, Zhao Ding, Xue Yang, Yuan Jiang, Yu Wu, Yehai Liu, Jing Wu
Summary: This study identified ten genes associated with HNSCC and established a risk score based on these genes. By constructing a diagnostic model, it was found that the high-risk group had higher sensitivity to common chemotherapeutic drugs. Additionally, the expression of DCLRE1C was higher in HNSCC tissues compared to normal tissues.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Ruoyan Cao, Weilin Zhang, Hongjian Zhang, Lixuan Wang, Xijuan Chen, Xianyue Ren, Bin Cheng, Juan Xia
Summary: The peroxidase family of peroxiredoxins (PRDXs) plays a vital role in maintaining the intracellular balance of ROS in head and neck squamous cell carcinoma (HNSCC). The expression of PRDX1, PRDX4, and PRDX5 in HNSCC is increased, while the expression of PRDX2 is decreased. Higher expression of PRDX4/5/6 indicates poor prognosis, while lower expression of PRDX1/5 is associated with more immune cell infiltration, higher expression of immune-related molecules, and a likely response to anti-PD-1 treatment. Knockdown of PRDX5 inhibits HNSCC cell proliferation, invasion, and metastasis, and promotes apoptosis through its antioxidant property. This study highlights the potential role of PRDXs, particularly PRDX5, in HNSCC and suggests it as a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zirong Huo, Xiaoguang Li, Jieyu Zhou, Yuqin Fan, Zhentao Wang, Zhihua Zhang
Summary: DNA methylation and miRNA-target genes are important in tumor development, and PLAU was found to be overexpressed in HNSCC, serving as an independent diagnostic and prognostic biomarker. The study also suggested that hypomethylation and downregulation of miR-23b-3p may contribute to the oncogenic role of PLAU in HNSCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Miaomiao Liu, Wei Wang, Songlin Piao, Yuchen Shen, Zhengmiao Li, Wentong Ding, Jichen Li, Wuliji Saiyin
Summary: This study investigated the expression of BGN and DCN in oral squamous cell carcinoma (OSCC) and found that the up-regulation of BGN and down-regulation of DCN were associated with the malignant degree and survival rate of OSCC.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Oncology
Yuchen Shen, Xinyu Li, Deming Wang, Liming Zhang, Xiao Li, Lixin Su, Xindong Fan, Xitao Yang
Summary: This study aimed to identify a novel prognostic biomarker for head and neck squamous cell carcinoma (HNSCC) based on tumor immunology-related alternative splicing (AS). Through the establishment of an AS-related risk model, the researchers found that Collagen Type III Alpha 1 Chain (COL3A1) is a reliable biomarker for predicting the prognosis of HNSCC patients. COL3A1 expression levels were elevated in HNSCC tissues compared to normal tissues and were associated with HNSCC differentiation and T stage. Additionally, COL3A1 was found to be better at evaluating immune cell infiltrations and activities in HNSCC lesions compared to the risk model.
Article
Peripheral Vascular Disease
Yuchen Shen, Zhenfeng Wang, Lixin Su, Lianzhou Zheng, Yifeng Han, Xiaohui Jiao, Xindong Fan, Deming Wang
Summary: This study aimed to investigate the preventive effect of losartan on acute elevation of pulmonary arterial pressure (AEPAP) induced by endovascular ethanol injection and explore its underlying mechanisms. The results showed that losartan failed to completely inhibit AEPAP and only partially reversed ethanol-induced pulmonary artery remodeling. The elevation of AEPAP was mainly caused by the activation of the renin-angiotensin system (RAS) and P38 MAPK signaling. Losartan partially prevented AEPAP and vascular remodeling by promoting NADPH oxidase (NOX) activity, which was independent of RAS.
HYPERTENSION RESEARCH
(2023)
Article
Surgery
Yuchen Shen, Lixin Su, Zhenfeng Wang, Xindong Fan, Deming Wang
Summary: In this study, we reported a case of a patient with Maffucci syndrome and evaluated the outcomes of surgical management combined with sclerotherapy in the treatment of head and neck venous malformations. The combination of local resection and sclerotherapy successfully removed the VMs from the patient's head and neck region, restoring appearance and normal function.
VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Liming Zhang, Yuchen Shen, Zhenfeng Wang, Xiao Li, Weiya Xia, Xindong Fan, Lixin Su, Deming Wang
Summary: Comparative high-throughput sequencing revealed differentially expressed circRNAs, lncRNAs, and mRNAs in serum exosomes, which are related to the formation of VM. Functional analysis showed that these differentially expressed RNAs play significant roles in thyroid hormone signaling, MAPK signaling, and hepatocellular carcinoma. This study provides new insights into the pathogenesis of VM and identifies potential targets for its treatment.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Yuchen Shen, Xiaotong Wang, Lixin Su, Xiaohui Jiao, Xindong Fan, Deming Wang
Editorial Material
Clinical Neurology
Xitao Yang, Lixin Su, Deming Wang, Yuchen Shen
ANNALS OF NEUROLOGY
(2023)
Editorial Material
Dermatology
Xitao Yang, Yuchen Shen
Article
Surgery
Yuchen Shen, Deming Wang, Mingzhe Wen, Lixin Su, Xindong Fan, Xitao Yang
Summary: The present study divided palpebral arteriovenous malformations (pAVMs) into cystic and diffuse types based on their angiographic characteristics. Ethanol embolization combined with coils was found to be effective for treating cystic pAVMs, while ethanol embolization without coils was more suitable for diffuse pAVMs. The long-term clinical outcomes of diffuse pAVMs were poorer compared to cystic pAVMs.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Surgery
Lixin Su, Xitao Yang, Zhenfeng Wang, Mingzhe Wen, Xindong Fan, Deming Wang
Summary: This study summarized the experience of locating the nidus of lower extremity arteriovenous malformations (AVMs) with dominant outflow veins (DOV) and eradicating it using ethanol and coils. Twelve patients underwent ethanol embolization combined with DOV occlusion, and selective angiography was used for locating the AVM nidus. The results showed that the procedure had a high success rate with acceptable complication rates.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)
Article
Surgery
Yuchen Shen, Deming Wang, Mingzhe Wen, Ruoyu Di, Xindong Fan, Lixin Su, Xitao Yang
Summary: This study evaluated the outcomes of coil-assisted ethanol embolotherapy in patients with recanalized head and neck arteriovenous malformations (HNAVMs) with dilated outflowing veins after Onyx treatment. The results showed that coil-assisted ethanol embolotherapy effectively improved the response rate and recurrence-free survival rate in these patients.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)
