Journal
SMALL
Volume 18, Issue 6, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202104820
Keywords
3D printing; bioinks; dual-network; living materials
Categories
Funding
- National Key Research and Development Program of China [2018YFA0902200, 2019YFA0905500]
- National Natural Science Foundation of China [21901117, 21736006]
- Natural Science Foundation of Jiangsu Province [BK20190674]
- Jiangsu Specially Appointed Professor Program, Fund of State Key Laboratory of Materials Oriented Chemical Engineering [ZK201809]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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The field of living materials aims to utilize living cells as microfactories to construct materials or enhance material performance. Recent advancements in 3D printing enable microbe manipulation for bespoke living materials, but effective coupling of these living components remains challenging.
The field of living materials seeks to harness living cells as microfactories that can construct a material itself or enhance the performance of material in some manner. While recent advances in 3D printing allow microbe manipulation to create bespoke living materials, the effective coupling of these living components in reinforced bioink designs remains a major challenge due to the difficulty in building a robust and cell-friendly microenvironment. Here, a type of dual-network bioink is reported for the 3D printing of living materials with enhanced biocatalysis capabilities, where bioinks are readily printable and provide a biocompatible environment along with desirable mechanical performance. It is demonstrated that integrating microbes into these bioinks enables the direct printing of catalytically living materials with high cell viability and maintains metabolic activity, which those living materials can be preserved and reused. Further, a bacteria-algae coculture system is fabricated for the bioremediation of chemicals, giving rise to its potential field applications.
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