Virus neutralisation by intracellular antibodies

Target-induced clustering activates Trim-Away of pathogens and proteins

(2021) Jingwei Zeng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination

(2021) Leo Kiss et al.   Nature Communications

A functional assay for serum detection of antibodies against SARS‐CoV‐2 nucleoprotein

(2021) Anna Albecka et al.   EMBO JOURNAL

Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology

(2020) Congcong Zhang et al.   BIODRUGS

The Nucleocapsid Protein of SARS–CoV-2: a Target for Vaccine Development

(2020) Noton K. Dutta et al.   JOURNAL OF VIROLOGY

The SARS-CoV-2 N protein is a good component in a vaccine

(2020) Gustaf Ahlén et al.   JOURNAL OF VIROLOGY

Intracellular neutralisation of rotavirus by VP6-specific IgG

(2020) Sarah L. Caddy et al.   PLoS Pathogens

ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection

(2020) Asmaa Hachim et al.   NATURE IMMUNOLOGY

A Decade in Review: A Systematic Review of Universal Influenza Vaccines in Clinical Trials during the 2010 Decade

(2020) Brigette N. Corder et al.   Viruses-Basel

Rotavirus VP6 as a potential vaccine candidate

(2019) Atefeh Afchangi et al.   REVIEWS IN MEDICAL VIROLOGY

Complement C4 Prevents Viral Infection through Capsid Inactivation

(2019) Maria Bottermann et al.   Cell Host & Microbe

The Neonatal Fc Receptor (FcRn): A Misnomer?

(2019) Michal Pyzik et al.   Frontiers in Immunology

A review of Lassa fever vaccine candidates

(2019) Kolawole Salami et al.   Current Opinion in Virology

The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity

(2018) Holly Turula et al.   Viruses-Basel

A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway

(2018) Jun-Fang Zhang et al.   Theranostics

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

(2018) Claire Dickson et al.   eLife

TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination

(2018) Maria Bottermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM21 and the Function of Antibodies inside Cells

(2017) David A. Rhodes et al.   TRENDS IN IMMUNOLOGY

Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein

(2017) Kseniya Khamina et al.   PLoS Pathogens

Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging

(2017) Tamarand Lee Darling et al.   Frontiers in Immunology

Epitope-Specific Suppression of IgG Responses by Passively Administered Specific IgG: Evidence of Epitope Masking

(2017) Joakim J. E. Bergström et al.   Frontiers in Immunology

Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism

(2016) Wenchun Fan et al.   ANTIVIRAL RESEARCH

TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity

(2016) Stian Foss et al.   JOURNAL OF IMMUNOLOGY

Coordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21

(2016) Adam J. Fletcher et al.   JOURNAL OF VIROLOGY

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

(2016) Leo Hanke et al.   mBio

Fusion of the mouse IgG1 Fc domain to the VHH fragment (ARP1) enhances protection in a mouse model of rotavirus

(2016) Gökçe Günaydın et al.   Scientific Reports

Antibody-antigen kinetics constrain intracellular humoral immunity

(2016) Maria Bottermann et al.   Scientific Reports

FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin

(2015) Michal Pyzik et al.   JOURNAL OF IMMUNOLOGY

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

(2015) Adam J. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Role for Non-Neutralizing Antibodies against Nucleoprotein in Facilitating Resistance to Influenza Virus

(2014) D. M. Carragher et al.   JOURNAL OF IMMUNOLOGY

Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells

(2014) Susanna R. Bidgood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rotaviruses

(2014) Ulrich Desselberger   VIRUS RESEARCH

IgGs are made for walking on bacterial and viral surfaces

(2014) Johannes Preiner et al.   Nature Communications

Antigen Cross-Presentation of Immune Complexes

(2014) Barbara Platzer et al.   Frontiers in Immunology

Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcγR

(2013) Tobias Straub et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Non-neutralizing antibodies protect from chronic LCMV infection independently of activating FcγR or complement

(2013) Kirsten Richter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Simultaneous Neutralization and Innate Immune Detection of a Replicating Virus by TRIM21

(2013) R. E. Watkinson et al.   JOURNAL OF VIROLOGY

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore

(2013) Mohammed S. Aiyegbo et al.   PLoS One

Intracellular antibody receptor TRIM21 prevents fatal viral infection

(2013) M. Vaysburd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

(2013) Brian J. Laidlaw et al.   PLoS Pathogens

Secretory IgA: Designed for Anti-Microbial Defense

(2013) Per Brandtzaeg   Frontiers in Immunology

Regulation of Virus Neutralization and the Persistent Fraction by TRIM21

(2012) W. A. McEwan et al.   JOURNAL OF VIROLOGY

Nanobodies®: New ammunition to battle viruses

(2011) Peter Vanlandschoot et al.   ANTIVIRAL RESEARCH

Contributions of Antinucleoprotein IgG to Heterosubtypic Immunity against Influenza Virus

(2011) Mark W. LaMere et al.   JOURNAL OF IMMUNOLOGY

Matrix Protein-Specific IgA Antibody Inhibits Measles Virus Replication by Intracellular Neutralization

(2011) D. Zhou et al.   JOURNAL OF VIROLOGY

Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport

(2011) Y. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

(2011) Kyudong Han et al.   PLoS Genetics

VP6: A Candidate Rotavirus Vaccine

(2010) Richard L. Ward et al.   JOURNAL OF INFECTIOUS DISEASES

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

(2010) D. L. Mallery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Therapeutic Antibody against West Nile Virus Neutralizes Infection by Blocking Fusion within Endosomes

(2009) Bruce S. Thompson et al.   PLoS Pathogens

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved

(2008) A. H. Keeble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA