Rotavirus VP6 as a potential vaccine candidate

Viral gastroenteritis

(2018) Krisztián Bányai et al.   LANCET

Enhancement of VP6 immunogenicity and protective efficacy against rotavirus by VP2 in a genetic immunization

(2018) D.V. Lopez-Guerrero et al.   VACCINE

Immunization of Mice by Rotavirus NSP4-VP6 Fusion Protein Elicited Stronger Responses Compared to VP6 Alone

(2018) Atefeh Afchangi et al.   VIRAL IMMUNOLOGY

Rotavirus VP6 protein mucosally delivered by cell wall-derived particles from Lactococcus lactis induces protection against infection in a murine model

(2018) C. Facundo Temprana et al.   PLoS One

Candidate new rotavirus species in Schreiber's bats, Serbia

(2017) Krisztián Bányai et al.   INFECTION GENETICS AND EVOLUTION

Efficacy of a Low-Cost, Heat-Stable Oral Rotavirus Vaccine in Niger

(2017) Sheila Isanaka et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advancements in DNA vaccine vectors, non-mechanical delivery methods, and molecular adjuvants to increase immunogenicity

(2017) John J. Suschak et al.   Human Vaccines & Immunotherapeutics

Oral Administration of a Seed-based Bivalent Rotavirus Vaccine Containing VP6 and NSP4 Induces Specific Immune Responses in Mice

(2017) Hao Feng et al.   Frontiers in Plant Science

Global, Regional, and National Estimates of Rotavirus Mortality in Children

(2016) Jacqueline E. Tate et al.   CLINICAL INFECTIOUS DISEASES

Rotavirus Recombinant VP6 Nanotubes Act as an Immunomodulator and Delivery Vehicle for Norovirus Virus-Like Particles

(2016) Maria Malm et al.   Journal of Immunology Research

Anti-VP6 VHH: An Experimental Treatment for Rotavirus A-Associated Disease

(2016) Lucía Maffey et al.   PLoS One

Protection against live rotavirus challenge in mice induced by parenteral and mucosal delivery of VP6 subunit rotavirus vaccine

(2015) Suvi Lappalainen et al.   ARCHIVES OF VIROLOGY

Zoonotic transmission of rotavirus: surveillance and control

(2015) Renáta Dóró et al.   Expert Review of Anti-Infective Therapy

Targeting of rotavirus VP6 to DEC-205 induces protection against the infection in mice

(2015) O. Badillo-Godinez et al.   VACCINE

Rotavirus capsid VP6 protein acts as an adjuvant in vivo for norovirus virus-like particles in a combination vaccine

(2015) Vesna Blazevic et al.   Human Vaccines & Immunotherapeutics

Efficacy of a monovalent human-bovine (116E) rotavirus vaccine in Indian infants: a randomised, double-blind, placebo-controlled trial

(2014) Nita Bhandari et al.   LANCET

Efficacy of a monovalent human-bovine (116E) rotavirus vaccine in Indian children in the second year of life

(2014) Nita Bhandari et al.   VACCINE

Improved characteristics and protective efficacy in an animal model of E. coli-derived recombinant double-layered rotavirus virus-like particles

(2014) Tingdong Li et al.   VACCINE

The assembly conformation of rotavirus VP6 determines its protective efficacy against rotavirus challenge in mice

(2014) Ana Ruth Pastor et al.   VACCINE

A New Rotavirus VP6-Based Foreign Epitope Presenting Vector and Immunoreactivity of VP4 Epitope Chimeric Proteins

(2014) Yumei Teng et al.   VIRAL IMMUNOLOGY

Rotaviruses

(2014) Ulrich Desselberger   VIRUS RESEARCH

Immune responses elicited against rotavirus middle layer protein VP6 inhibit viral replication in vitro and in vivo

(2014) Suvi Lappalainen et al.   Human Vaccines & Immunotherapeutics

Understanding internalization of rotavirus VP6 nanotubes by cells: towards a recombinant vaccine

(2013) Mabel Rodríguez et al.   ARCHIVES OF VIROLOGY

Differential Accessibility of a Rotavirus VP6 Epitope in Trimers Comprising Type I, II, or III Channels as Revealed by Binding of a Human Rotavirus VP6-Specific Antibody

(2013) M. S. Aiyegbo et al.   JOURNAL OF VIROLOGY

Trivalent Combination Vaccine Induces Broad Heterologous Immune Responses to Norovirus and Rotavirus in Mice

(2013) Kirsi Tamminen et al.   PLoS One

Comparative immunogenicity in mice of rotavirus VP6 tubular structures and virus-like particles

(2013) Suvi Lappalainen et al.   Human Vaccines & Immunotherapeutics

Recombinant Monovalent Llama-Derived Antibody Fragments (VHH) to Rotavirus VP6 Protect Neonatal Gnotobiotic Piglets against Human Rotavirus-Induced Diarrhea

(2013) Celina G. Vega et al.   PLoS Pathogens

Antigenicity and Immunogenicity of Rotavirus VP6 Protein Expressed on the Surface ofLactococcus lactis

(2013) L. E. Esteban et al.   Biomed Research International

VP6-sequence-based cutoff values as a criterion for rotavirus species demarcation

(2012) Jelle Matthijnssens et al.   ARCHIVES OF VIROLOGY

Rotavirus A-specific single-domain antibodies produced in baculovirus-infected insect larvae are protective in vivo

(2012) Silvia Gómez-Sebastián et al.   BMC BIOTECHNOLOGY

In Vitro Neutralisation of Rotavirus Infection by Two Broadly Specific Recombinant Monovalent Llama-Derived Antibody Fragments

(2012) Farah Aladin et al.   PLoS One

IgY Antibodies Protect against Human Rotavirus Induced Diarrhea in the Neonatal Gnotobiotic Piglet Disease Model

(2012) Celina G. Vega et al.   PLoS One

Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG)

(2011) Jelle Matthijnssens et al.   ARCHIVES OF VIROLOGY

2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis

(2011) Jacqueline E Tate et al.   LANCET INFECTIOUS DISEASES

Prime immunization with rotavirus VLP 2/6 followed by boosting with an adenovirus expressing VP6 induces protective immunization against rotavirus in mice

(2011) Hongli Zhou et al.   Virology Journal

Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial

(2010) K Zaman et al.   LANCET

Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in sub-Saharan Africa: a randomised, double-blind, placebo-controlled trial

(2010) George E Armah et al.   LANCET

Effect of Human Rotavirus Vaccine on Severe Diarrhea in African Infants

(2010) Shabir A. Madhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral administration of plant-based rotavirus VP6 induces antigen-specific IgAs, IgGs and passive protection in mice

(2010) Bo Zhou et al.   VACCINE

Chimeric recombinant rotavirus-like particles as a vehicle for the display of heterologous epitopes

(2009) Andrea Peralta et al.   Virology Journal

Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments

(2008) Jelle Matthijnssens et al.   ARCHIVES OF VIROLOGY

Determination of Human Rotavirus VP6 Genogroups I and II by Reverse Transcription-PCR

(2008) Y.-P. Lin et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Llama-Derived Single-Chain Antibody Fragments Directed to Rotavirus VP6 Protein Possess Broad Neutralizing Activity In Vitro and Confer Protection against Diarrhea in Mice

(2008) L. Garaicoechea et al.   JOURNAL OF VIROLOGY

Full Genome-Based Classification of Rotaviruses Reveals a Common Origin between Human Wa-Like and Porcine Rotavirus Strains and Human DS-1-Like and Bovine Rotavirus Strains

(2008) J. Matthijnssens et al.   JOURNAL OF VIROLOGY