Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Trine V. Larsen, Nina Dybdal, Tina F. Daugaard, Johanne Lade-Keller, Lin Lin, Boe S. Sorensen, Anders L. Nielsen
Summary: This study investigates the role of PD-L1 DNA methylation in regulating and predicting PD-L1 expression in non-small-cell lung cancer (NSCLC) patients undergoing immunotherapy. The analysis of tumor biopsies and cell lines reveals that PD-L1 DNA methylation status influences its expression. However, the correlation between methylation and expression is weak in NSCLC tumor samples. This study emphasizes the importance of further research to improve the effectiveness of PD-1/PD-L1 immunotherapy in NSCLC.
Review
Oncology
Raluca Munteanu, Ciprian Tomuleasa, Cristina-Adela Iuga, Diana Gulei, Tudor Eliade Ciuleanu, Triantafillos Liloglou
Summary: Understanding and applying epigenetic processes can revolutionize lung cancer care, improving treatment outcomes and quality of life. However, understanding the role of epigenetic drugs in treatment remains a challenge.
Review
Oncology
Asad Mohammad, Sudhakar Jha
Summary: Epigenetic modifications, such as DNA methylation and histone modification, play a crucial role in cancer progression and metastasis. Inhibitors targeting deregulated enzymes can reverse these modifications and show promising results in cancer therapeutics.
Article
Immunology
Chloe D. Goldsmith, Thomasina Donovan, Nicole Vlahovich, David B. Pyne
Summary: This perspective article discusses how exercise can delay T cell ageing by analyzing the relationship between metabolism and epigenetics, proposing a potential impact of exercise on CD4+ T cell plasticity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Heng Wee Tan, Yan-Ming Xu, San-Hai Qin, Guo-Feng Chen, Andy T. Y. Lau
Summary: Lung cancer is the leading cause of cancer-related deaths worldwide, with angiogenesis playing a crucial role in the growth and metastasis of lung cancer cells. While genetic regulation of angiogenesis in lung cancer is extensively studied, relatively less is known about the epigenetic regulation. Epigenetic alterations, including DNA epimodifications, histone posttranslational modifications, and noncoding RNA expression, contribute to regulating angiogenesis in lung cancer. In the future, epigenetic-based therapy is likely to emerge as a prominent approach for treating lung cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Chemistry, Medicinal
Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Yuan Zhou, Jun Ren
Summary: This article discusses the pathogenesis of alcohol-related liver disease (ARLD) and alcoholic liver disease (ALD), with a focus on the role of epigenetic factors in the development of liver disorders. Through cellular and animal model studies, the alcohol-induced epigenetic modifications (AIEM) and their relationship with liver diseases are explored, and epigenetics-based therapeutic options for managing ARLD and ALD are proposed.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Plant Sciences
Justin Su, Zhujun Yao, Yixuan Wu, Joohyun Lee, Jeeyon Jeong
Summary: This article mainly introduces the latest understanding of chromatin-based regulation of iron homeostasis in plants, highlighting recent studies in Arabidopsis and rice. Understanding iron homeostasis in plants is crucial as it is relevant to fundamental biological questions, agriculture, biofortification, and human health.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Dipanwita Das, Nandini Karthik, Reshma Taneja
Summary: Inflammation is a crucial immune response against infection and tissue damage, but chronic inflammation is linked to cancer development. Immune cells produce inflammatory mediators to facilitate tumor growth, while aberrant expression of inflammatory factors by tumor cells recruits immune cells for mutual crosstalk, creating a conducive environment for tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jing Sui, Wenliang Qiao, Xinrong Xiang, Youfu Luo
Summary: This article describes the epigenetic changes that occur in the pathogen Mycobacterium tuberculosis and its host during infection, including DNA methylation, histone modification, and microRNA. It summarizes the research progress in drug discovery and tuberculosis diagnosis, providing new ideas and strategies to combat drug-resistant tuberculosis.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Cell Biology
Xueren Li, Chunjing Feng, Shouchun Peng
Summary: Respiratory diseases, including lung cancer and pulmonary fibrosis, are associated with increased mortality and healthcare burden. Genetic information alone cannot fully explain respiratory diseases, and epigenetic mechanisms also play a role in genetic information transmission. Studying the role of altered epigenetic modifications is important for understanding the pathophysiological processes and causal relationships of lung diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Parvez Khan, Jawed Akhtar Siddiqui, Shailendra Kumar Maurya, Imayavaramban Lakshmanan, Maneesh Jain, Apar Kishor Ganti, Ravi Salgia, Surinder Kumar Batra, Mohd Wasim Nasser
Summary: SCLC is a subtype of lung cancer with high mortality, where epigenetic modifications play a crucial role in tumorigenesis, progression, and drug resistance. Understanding SCLC epigenetics is important for prognostication, treatment stratification, and the development of new therapies.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Immunology
Avinash Khadela, Vivek P. Chavda, Humzah Postwala, Yesha Shah, Priya Mistry, Vasso Apostolopoulos
Summary: Tuberculosis is a highly challenging and chronic infection that requires the action of the host's immune system. Epigenetic modification plays a crucial role in the pathophysiology and treatment of tuberculosis, but there are still gaps in the research.
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Oncology
Florian Janke, Arlou Kristina Angeles, Anja Lisa Riediger, Simone Bauer, Martin Reck, Albrecht Stenzinger, Marc A. Schneider, Thomas Muley, Michael Thomas, Petros Christopoulos, Holger Sueltmann
Summary: This study demonstrates the potential of DNA methylation biomarkers in prognosis and therapy monitoring of ALK-positive NSCLC patients. The research highlights the suitability of cfDNA methylation as a non-invasive biomarker for tumor detection and its correlation with other genomic alterations.
CLINICAL EPIGENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Qing Li, Zhi-Wei Zhou, Jia Lu, Hao Luo, Shu-Nan Wang, Yu Peng, Meng-Sheng Deng, Guan-Bin Song, Jian-Min Wang, Xi Wei, Dong Wang, Kenneth D. Westover, Cheng-Xiong Xu
Summary: This study found that the rs17718883 polymorphism in the PD-L1 gene affects the PD-1/PD-L1 interaction, leading to ineffectiveness of PD-1/PD-L1 blockade therapy in certain gastric cancer patients. The study suggests that rs17718883 could be used as a screening biomarker to exclude patients who are not suitable for PD-1/PD-L1 blockade therapy.
Article
Materials Science, Biomaterials
Hong Li, Yuchuan Sun, Qing Li, Qing Luo, Guanbin Song
Summary: Hepatocellular carcinoma tissue exhibits mechanical heterogeneity, with increasing stiffness from the core to the invasion front. Liver cancer stem cells (LCSCs), which preferentially enrich the invasion front, also demonstrate the highest stiffness in the tumor. A stiffer matrix significantly enhances LCSC stemness, potentially mediated by Yes-associated protein signaling. Our findings reveal the relationship between matrix stiffness and LCSC stemness, contributing to the development of novel treatment approaches for liver cancer.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Oncology
Xiaoqing Fan, Shaolin Tao, Qing Li, Bo Deng, Qun-You Tan, Hua Jin
Summary: Simultaneous overexpression of all miRNAs in the miR-23a/27a/24-2 cluster is closely associated with postoperative recurrence in early-stage NSCLC patients. These miRNAs simultaneously stimulate Wnt/beta-catenin signaling, promoting the progression of early-stage NSCLC. Inhibition of all miRNAs in the miR-23a/27a/24-2 cluster may be a useful strategy for treating recurrence in early-stage NSCLC.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Biochemistry & Molecular Biology
Pu Xu, Bingyu Zhang, Bin Deng, Qing Luo, Guanbin Song
Summary: This study investigated the molecular mechanisms of mechanical stretch-induced Tnmd expression. It was found that mechanical stretch promoted Tnmd expression by activating ERK1/2, JNK, and p38 signaling, leading to reinforcement of F-actin stress fibers and chromatin decondensation. Only the inhibition of ERK1/2 and p38 had an effect on mechanical stretch-induced chromatin decondensation, while the JNK inhibitor did not. These findings elucidate a molecular pathway by which mechanical signals influence Tnmd expression to promote tenocyte migration, through activation of MAPK signaling and reinforcement of F-actin stress fibers and chromatin decondensation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Rushuang Xu, Shan He, Di Ma, Rui Liang, Qing Luo, Guanbin Song
Summary: In this study, the role of plectin in the migration and epithelial mesenchymal transition (EMT) of hepatocellular carcinoma (HCC) cells was investigated. Plectin expression was found to be significantly increased in HCC tissue and cells. Downregulation of plectin inhibited HCC cell migration and EMT, which was mediated by the suppression of ERK1/2 signaling. Activation of ERK1/2 reversed the inhibitory effects of plectin downregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Qing Li, Meng-Sheng Deng, Ren-Tao Wang, Hao Luo, Yuan-Yuan Luo, Dong-Dong Zhang, Kui-Jun Chen, Xiao-Fu Cao, Guang-Ming Yang, Tie-Mei Zhao, Bo Xu, Cheng-Xiong Xu, Jian-Min Wang
Summary: This study demonstrated that PD-L1 is upregulated in fibrotic lung tissues and sera of IPF patients. PD-L1 upregulation stimulates EMT (Epithelial-Mesenchymal Transition) and fibrosis-like morphology changes by inhibiting vimentin ubiquitination and increasing vimentin levels in alveolar epithelial cells, contributing to pulmonary fibrosis.
PHARMACOLOGICAL RESEARCH
(2023)
Editorial Material
Biochemistry & Molecular Biology
Guanbin Song
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaorong Fu, Yasuhiro Kimura, Yuhki Toku, Guanbin Song, Yang Ju
Summary: The 3D extracellular matrix microenvironment plays a crucial role in regulating tumor stiffness, and different matrix stiffnesses have a significant impact on the metabolic phenotypes of cancer cells. Culturing non-small cell lung cancer cells in 3D collagen-chitosan scaffolds showed increased mitochondrial and fatty acid metabolism compared to 2D culture. Moreover, cells cultured in scaffolds of medium stiffness displayed higher metabolic potential than stiffer and softer scaffolds.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cell Biology
Pu Xu, Bingyu Zhang, Qing Luo, Guanbin Song
Summary: Early controlled motion has a beneficial effect on tendon healing and function recovery, although the underlying mechanisms remain unclear. This study demonstrated that mechanical stretch can enhance rat tenocyte migration and induce nuclear morphology changes, mainly through chromatin remodeling. These findings contribute to a better understanding of the role of mechanical stretch in tendon repair.
WOUND REPAIR AND REGENERATION
(2023)
Article
Chemistry, Multidisciplinary
Qing Li, Hao Luo, Fu-Qiang Dai, Ren-Tao Wang, Xiao-Qing Fan, Yuan-Yuan Luo, Meng-Sheng Deng, Yulun Wang, Tan Long, Wei Guo, Bo Xu, Cheng-Xiong Xu, Hua Jin
Summary: In this study, the authors identified SAMD9 as a predictor and promoter of postoperative recurrence in ESCC. SAMD9 activates the Wnt/β-catenin signaling pathway, enhancing tumor stemness, angiogenesis, and EMT. Silencing SAMD9 or related genes MYH9 and β-catenin can inhibit multiple malignant properties of ESCC. SAMD9 has the potential to be a predictive biomarker and crucial therapeutic target for ESCC.
Article
Cell Biology
Yuhao Zhou, Wenjun Lv, Xiufen Peng, Yansiwei Cheng, Yun Tu, Guanbin Song, Qing Luo
Summary: This study investigates the effects of simulated microgravity on cutaneous wound healing and dermal fibroblast migration. The results demonstrate that simulated microgravity inhibits the healing of cutaneous wound and reduces the accumulation of dermal fibroblasts in the wound bed. In vitro experiments show that simulated microgravity inhibits the migration of human foreskin fibroblast cells and reduces F-actin polymerization and YAP activity. Treatment with lysophosphatidic acid is able to recover the inhibited migration and improve cutaneous healing in simulated microgravity rats. These findings suggest the crucial role of the F-actin/YAP signaling pathway in the maintenance of skin homeostasis and propose YAP as a potential therapeutic target for astronauts in space.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Oncology
Xiaoyu Chen, Ying Li, Zhiwei Zhou, Yanqiu Zhang, Luchen Chang, Xiujun Gao, Qing Li, Hao Luo, Kenneth D. Westover, Jialin Zhu, Xi Wei
Summary: This study firstly found that reversible senescence contributed to lapatinib (LAP) resistance in HER2+ breast cancer and identified ecto-5'-nucleotidase (NT5E) as a marker of reversible senescence in HER2+ breast cancer. We constructed NT5E targeted nanobubbles (NT5E-FITC-NBs) as a new molecular imaging modality which could both target reversible senescent cells and be used for ultrasound imaging. Cellular senescence-based ultrasound targeted imaging could identify reversible senescence early and evaluate LAP resistance effectively in HER2+ breast cancer.
Article
Biochemistry & Molecular Biology
Shan He, Ruihan Liu, Qing Luo, Guanbin Song
Summary: This study found that tensile overload induced apoptosis and proliferation in BEAS-2B cells, activated the MAPK signaling pathway and YAP, and led to the depolymerization of the actin cytoskeleton. Treatment with jasplakinolide promoted the polymerization of the actin cytoskeleton and reduced cell apoptosis by inhibiting JNK and ERK1/2 signaling pathways and the expression of YAP. The YAP/F-actin/MAPK axis plays a role in tensile-induced cell injury and provides new strategies for the treatment and repair of lung injuries.
Review
Oncology
Xiaorong Fu, Yi Zhang, Qing Luo, Yang Ju, Guanbin Song
Summary: Cancer stem cells (CSCs) have been recognized as the underlying cause of cancer occurrence, progression, resistance to treatment, recurrence, and metastasis. Targeting CSCs has emerged as a novel therapeutic strategy for cancer management. This review summarizes the current understanding of the roles of the liver mechanical microenvironment and liver cancer stem cells (LCSCs) in the progression of liver cancer. It also explores the relationship between the mechanical heterogeneity of liver cancer tissues and the recruitment and metastasis of LCSCs. Additionally, potential mechanosensitive molecules in LCSCs and mechanotherapy in liver cancer are discussed. Understanding the mechanisms and regulation of the mechanical microenvironment and LCSCs can provide crucial insights into liver cancer progression and facilitate the development of new therapeutic strategies.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Oncology
Hao Luo, Qing Li, Ren-Tao Wang, Liang Zhang, Wei Zhang, Meng-Sheng Deng, Yuan-Yuan Luo, Xintong Ji, Yongheng Wen, Xuan-Rui Zhou, Bo Xu, Dong Wang, Bin Hu, Hua Jin, Cheng-Xiong Xu
Summary: This study found that low expression of pro-SFTPB in primary NSCLC is closely associated with recurrence and poor prognosis in early-stage NSCLC patients. Mechanistically, downregulation of pro-SFTPB promotes the activation of the Akt pathway by upregulating PGK1, leading to the progression of early-stage NSCLC.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
