Alloantigen-specific type 1 regulatory T cells suppress through CTLA-4 and PD-1 pathways and persist long-term in patients

Pegilodecakin as monotherapy or in combination with anti‐PD ‐1 or tyrosine kinase inhibitor in heavily pretreated patients with advanced renal cell carcinoma ( RCC ): Final results of cohorts A, G, H, and I of IVY Phase I study

(2021) Nizar M. Tannir et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity

(2021) Yugang Guo et al.   NATURE IMMUNOLOGY

Regulatory Type 1 T Cell Infusion in Mismatched Related or Unrelated Hematopoietic Stem Cell Transplantation (HSCT) for Hematologic Malignancies

(2020) Rajni Agarwal et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires

(2020) Cinque Soto et al.   Cell Reports

The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology

(2020) Yasmin R. Mohseni et al.   Frontiers in Immunology

Randomized Phase 2 Studies of Checkpoint Inhibitors Alone or in Combination With Pegilodecakin in Patients With Metastatic NSCLC (CYPRESS 1 and CYPRESS 2)

(2020) David Spigel et al.   Journal of Thoracic Oncology

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

(2019) Takahiro Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8+ T Cell Apoptosis

(2019) Jian Qiao et al.   CANCER CELL

Suppressive and Gut Reparative Functions of Human Type 1 T-regulatory Cells

(2019) Laura Cook et al.   GASTROENTEROLOGY

Pegilodecakin combined with pembrolizumab or nivolumab for patients with advanced solid tumours (IVY): a multicentre, multicohort, open-label, phase 1b trial

(2019) Aung Naing et al.   LANCET ONCOLOGY

Intestinal IFN-γ–producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease

(2018) Johanna Sophie Alfen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

(2018) James M. Mathew et al.   Scientific Reports

Interleukin-10-Producing DC-10 Is a Unique Tool to Promote Tolerance Via Antigen-Specific T Regulatory Type 1 Cells

(2018) Michela Comi et al.   Frontiers in Immunology

Induction and transcriptional regulation of the co-inhibitory gene module in T cells

(2018) Norio Chihara et al.   NATURE

PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients

(2018) Aung Naing et al.   CANCER CELL

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

(2018) Maria Grazia Roncarolo et al.   IMMUNITY

Tregopathies: Monogenic diseases resulting in regulatory T-cell deficiency

(2018) Alma-Martina Cepika et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

(2018) Leonie Brockmann et al.   Nature Communications

IL-10-Engineered Human CD4 + Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism

(2017) Grazia Locafaro et al.   MOLECULAR THERAPY

Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses

(2017) Sofia Tousa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allogeneic Stem Cell Transplantation: A Historical and Scientific Overview

(2016) Anurag K. Singh et al.   CANCER RESEARCH

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes

(2016) Anne M. Pesenacker et al.   DIABETES

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation

(2016) Kankana Bardhan et al.   Frontiers in Immunology

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

(2015) Ivan D Mascanfroni et al.   NATURE MEDICINE

MiXCR: software for comprehensive adaptive immunity profiling

(2015) Dmitriy A Bolotin et al.   NATURE METHODS

Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses

(2015) Ruijie Liu et al.   NUCLEIC ACIDS RESEARCH

Graft-versus-host disease versus graft-versus-leukemia

(2015) R. S. Negrin   Hematology-American Society of Hematology Education Program

Braking Bad: Novel Mechanisms of CTLA-4 Inhibition of T Cell Responses

(2014) S. M. Krummey et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Novel GMP-Compatible Protocol Employing an Allogeneic B Cell Bank for Clonal Expansion of Allospecific Natural Regulatory T Cells

(2014) S. Landwehr-Kenzel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1

(2014) Christina Heinemann et al.   Nature Communications

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells

(2014) Rosa Bacchetta et al.   Frontiers in Immunology

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

(2013) S. Dong et al.   BLOOD

Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+T cells

(2013) Yukiko Iwasaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Regulatory T-cell subset analysis and profile of interleukin (IL)-10, IL-17 and interferon-gamma cytokine-producing cells in kidney allograft recipients with donor cells infusion

(2012) Moslem Ranjbar et al.   Clinical and Experimental Nephrology

Enforced IL-10 Expression Confers Type 1 Regulatory T Cell (Tr1) Phenotype and Function to Human CD4+ T Cells

(2012) Grazia Andolfi et al.   MOLECULAR THERAPY

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new

(2011) J. M. Coghill et al.   BLOOD

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

(2011) John B. Mumm et al.   CANCER CELL

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes

(2011) R. L. Warren et al.   GENOME RESEARCH

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

(2010) S. Gregori et al.   BLOOD

Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy

(2010) R. Bacchetta et al.   HAEMATOLOGICA

Testing significance relative to a fold-change threshold is a TREAT

(2009) D. J. McCarthy et al.   BIOINFORMATICS

Comprehensive assessment of T-cell receptor  -chain diversity in    T cells

(2009) H. S. Robins et al.   BLOOD

Antigen-Specific Dependence of Tr1-Cell Therapy in Preclinical Models of Islet Transplant

(2009) N. Gagliani et al.   DIABETES

Type 1 regulatory T cells are associated with persistent split erythroid/lymphoid chimerism after allogeneic hematopoietic stem cell transplantation for thalassemia

(2009) G. Serafini et al.   HAEMATOLOGICA

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

The Transcriptome of Human Cytotoxic T Cells: Similarities and Disparities Among Allostimulated CD4+CTL, CD8+CTL and NK cells

(2008) L. G. Hidalgo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Infectious complications of acute and chronic GVHD

(2008) Jo-Anne H. Young   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice

(2008) Julia Yuen-Shan Tsang et al.   JOURNAL OF CLINICAL INVESTIGATION