Development of ICT01, a first-in-class, anti-BTN3A antibody for activating Vγ9Vδ2 T cell–mediated antitumor immune response

Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer

(2021) Emelie Foord et al.   Science Translational Medicine

BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells

(2021) Carla E. Cano et al.   Cell Reports

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

(2020) Marc Rigau et al.   SCIENCE

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

(2020) Mohindar M. Karunakaran et al.   IMMUNITY

γδ T cells bring unconventional cancer-targeting to the clinic — again

(2020) Ken Garber   NATURE BIOTECHNOLOGY

HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers

(2020) Bob T. Li et al.   Cancer Discovery

Cancer immunotherapy with γδ T cells: many paths ahead of us

(2020) Dieter Kabelitz et al.   Cellular & Molecular Immunology

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

(2019) Yunyun Yang et al.   IMMUNITY

Anti-BTN3A 20.1 Agonist Monoclonal Antibody Enhances Autologous Vγ9Vδ2 T Cells Cytotoxicity Against Primary Acute Myeloid Blasts

(2019) Anne-Charlotte Le Floch et al.   BLOOD

Mechanisms of Resistance to PD-1 and PD-L1 Blockade

(2018) Theodore S. Nowicki et al.   CANCER JOURNAL

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

(2018) Pierre Vantourout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

(2018) Bruno Silva-Santos et al.   Frontiers in Immunology

Improving the Efficiency of Vγ9Vδ2 T-Cell Immunotherapy in Cancer

(2018) Timm Hoeres et al.   Frontiers in Immunology

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

(2018) André E. Simões et al.   Frontiers in Immunology

Integral Roles for Integrins in γδ T Cell Function

(2018) Gabrielle M. Siegers   Frontiers in Immunology

New Insights Into the Regulation of γδ T Cells by BTN3A and Other BTN/BTNL in Tumor Immunity

(2018) Juan-Luis Blazquez et al.   Frontiers in Immunology

Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That Affect Risk for Gastric Cancer

(2017) Meng Zhu et al.   GASTROENTEROLOGY

Evolutionary and polymorphism analyses reveal the central role of BTN3A2 in the concerted evolution of the BTN3 gene family

(2017) Hassnae Afrache et al.   IMMUNOGENETICS

Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation

(2017) Siyi Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Current Advances in γδ T Cell-Based Tumor Immunotherapy

(2017) Elena Lo Presti et al.   Frontiers in Immunology

BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC)

(2017) Audrey Benyamine et al.   OncoImmunology

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: Preclinical activity and safety in nonhuman primates

(2015) Gurunadh R. Chichili et al.   Science Translational Medicine

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos)

(2014) Mohindar M. Karunakaran et al.   IMMUNOGENETICS

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human    T-cell subset

(2012) C. Harly et al.   BLOOD

What lessons can be learned from γδ T cell-based cancer immunotherapy trials?

(2012) Jean-Jacques Fournié et al.   Cellular & Molecular Immunology

The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response

(2012) Hassnae Afrache et al.   IMMUNOGENETICS

The Molecular Basis for Modulation of Human Vγ9Vδ2 T Cell Responses by CD277/Butyrophilin-3 (BTN3A)-specific Antibodies

(2012) Aparna Palakodeti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours

(2011) A J Nicol et al.   BRITISH JOURNAL OF CANCER

Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma

(2011) Hirohito Kobayashi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies

(2009) J. Gertner-Dardenne et al.   BLOOD