Physiological levels of 25‐hydroxyvitamin D 3 induce a suppressive CD4 + T cell phenotype not reflected in the epigenetic landscape

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

(2021) Gerdien Mijnheer et al.   Nature Communications

Regulatory T Cells and Human Disease

(2020) Shimon Sakaguchi et al.   Annual Review of Immunology

Vitamin D deficiency 2.0: an update on the current status worldwide

(2020) Karin Amrein et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

New aspects of vitamin D metabolism and action — addressing the skin as source and target

(2020) Daniel Bikle et al.   Nature Reviews Endocrinology

Immunologic Effects of Vitamin D on Human Health and Disease

(2020) Nipith Charoenngam et al.   Nutrients

Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis

(2019) Danyang Li et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vitamin D-modulated dendritic cells delay lethal graft-versus-host disease through induction of regulatory T cells

(2019) An-Sofie Vanherwegen et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review

(2019) Sheila A. Fisher et al.   PLoS One

Dendritic cells and regulatory T cells expressing CCR4 provide resistance to coxsackievirus B5-induced pancreatitis

(2019) Marcela C. S. Françozo et al.   Scientific Reports

Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity

(2019) Hao Shi et al.   Frontiers in Immunology

Vitamin D alleviates acute graft-versus-host disease through promoting the generation of Foxp3+ T cells

(2019) Chuangye Ni et al.   Annals of Translational Medicine

CCR4 Antagonists Inhibit Treg Trafficking into the Tumor Microenvironment

(2018) John M. Ketcham et al.   ACS Medicinal Chemistry Letters

Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism

(2018) An-Sofie Vanherwegen et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vitamin D increases programmed death receptor-1 expression in Crohn’s disease

(2017) Mia Bendix et al.   Oncotarget

CTLA-4 and PD-1 Pathways

(2016) Elizabeth I. Buchbinder et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Comparative effect of 25(OH)D3 and 1,25(OH)2D3 on Th17 cell differentiation

(2016) Lama Fawaz et al.   CLINICAL IMMUNOLOGY

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

Vitamin D and 1,25(OH)2D Regulation of T cells

(2015) Margherita Cantorna et al.   Nutrients

Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function

(2015) Louisa E. Jeffery et al.   PLoS One

Vitamin D-binding protein controls T cell responses to vitamin D

(2014) Martin Kongsbak et al.   BMC IMMUNOLOGY

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications

(2014) Daniel D. Bikle   CHEMISTRY & BIOLOGY

Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease

(2014) Margherita T Cantorna et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

tTregs, pTregs, and iTregs: similarities and differences

(2014) Ethan M. Shevach et al.   IMMUNOLOGICAL REVIEWS

1α,25-dihydroxyvitamin D3 in combination with transforming growth factor-βincreases the frequency of Foxp3+regulatory T cells through preferential expansion and usage of interleukin-2

(2014) Emma S. Chambers et al.   IMMUNOLOGY

Vitamin D Up-Regulates the Vitamin D Receptor by Protecting It from Proteasomal Degradation in Human CD4+ T Cells

(2014) Martin Kongsbak et al.   PLoS One

Regulatory T Cell-Derived IL-10 Ameliorates Crescentic GN

(2013) A. Ostmann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase

(2012) J.S. Adams et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL-10+CD4+T cells

(2012) Zoë Urry et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vitamin D receptor upregulation in alloreactive human T cells

(2012) Richard W. Joseph et al.   HUMAN IMMUNOLOGY

Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function

(2012) Sarah V.I. Milliken et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Availability of 25-Hydroxyvitamin D3 to APCs Controls the Balance between Regulatory and Inflammatory T Cell Responses

(2012) L. E. Jeffery et al.   JOURNAL OF IMMUNOLOGY

1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region

(2012) S. W. Kang et al.   JOURNAL OF IMMUNOLOGY

Seasonal Variation in Vitamin D3 Levels Is Paralleled by Changes in the Peripheral Blood Human T Cell Compartment

(2012) Ai-Leng Khoo et al.   PLoS One

Functional stability of Foxp3+ regulatory T cells

(2012) Maria da Silva Martins et al.   TRENDS IN MOLECULAR MEDICINE

25-hydroxyvitamin D3 conversion by dendritic cells and T cells drives 1,25-dihydroxyvitamin D3 mediated anti-inflammatory CD4+ T cell responses

(2011) L. Jeffery et al.   ANNALS OF THE RHEUMATIC DISEASES

The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: a randomized controlled trial

(2011) Gerlies Bock et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline

(2011) Michael F. Holick et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Whole-Body UVB Irradiation during Allogeneic Hematopoietic Cell Transplantation Is Safe and Decreases Acute Graft-versus-Host Disease

(2011) Marina Kreutz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vitamin D: modulator of the immune system

(2010) Femke Baeke et al.   CURRENT OPINION IN PHARMACOLOGY

Isolation of intact genomic DNA from FOXP3-sorted human regulatory T cells for epigenetic analyses

(2010) Leo Hansmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system

(2010) Femke Baeke et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vitamin D controls T cell antigen receptor signaling and activation of human T cells

(2010) Marina Rode von Essen et al.   NATURE IMMUNOLOGY

1,25-dihydroxyvitamin D3modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis

(2009) E. M. Colin et al.   ARTHRITIS AND RHEUMATISM

Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity

(2009) C. Schmidl et al.   GENOME RESEARCH

1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3

(2009) L. E. Jeffery et al.   JOURNAL OF IMMUNOLOGY

25-Hydroxyvitamin D3 is an agonistic vitamin D receptor ligand

(2009) Yan-Ru Lou et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY