Article
Critical Care Medicine
A. A. Harhash, M. A. Kluge, A. Muthukrishnan, M. Noc, P. Radsel, J. C. Jentzer, D. B. Seder, K. Lee, K. Lotun, D. Stub, C-H. Hsu, K. B. Kern
Summary: Recent studies suggest that coronary angiography (CAG) should be considered for out-of-hospital cardiac arrest (OHCA) survivors, regardless of ST elevation (STE) and shockable rhythms. This re-analysis of the PEARL study found that OHCA survivors with nonshockable rhythms and no STE had similar prevalence of culprit coronary lesions as those with shockable rhythms. However, there was no benefit of emergent CAG for both shockable and nonshockable rhythms.
Article
Critical Care Medicine
Luke Andrea, Ariel L. Shiloh, Mai Colvin, Marjan Rahmanian, Maneesha Bangar, Anne Grossestreuer, Katherine M. Berg, Michelle N. Gong, Ari Moskowitz
Summary: PEA and asystole are common rhythms in IHCA, but they have distinct features in terms of location, resuscitation measures, and outcomes.
Article
Cardiac & Cardiovascular Systems
Chenyu Zhang, Haohong Zhan, Dawang Zhou, Tian Li, Qiang Zhang, Cong Liu, Hongyan Wei, Chunlin Hu
Summary: This study established a model of cardiac arrest caused by asphyxia induced by nonshockable rhythm. The longer the duration of cardiac arrest, the fewer surviving neurons and the more apoptotic cells there were. The study demonstrated that vecuronium bromide can successfully induce a model of cardiac arrest caused by nonshockable rhythm.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Critical Care Medicine
Alexiane Blanc, Gwenhael Colin, Alain Cariou, Hamid Merdji, Guillaume Grillet, Patrick Girardie, Elisabeth Coupez, Pierre-Francois Dequin, Thierry Boulain, Jean-Pierre Frat, Pierre Asfar, Nicolas Pichon, Mickael Landais, Gaetan Plantefeve, Jean-Pierre Quenot, Jean-Charles Chakarian, Michel Sirodot, Stephan Legriel, Nicolas Massart, Didier Thevenin, Arnaud Desachy, Arnaud Delahaye, Vlad Botoc, Sylvie Vimeux, Frederic Martino, Jean Reignier, F. S. Taccone, J. B. Lascarrou
Summary: Targeted temperature management (TTM) has demonstrated efficacy in attenuating the harmful effects of ischemia-reperfusion injury on the brain after cardiac arrest. However, its benefits in patients with in-hospital cardiac arrest (IHCA) remain unclear. This study aimed to investigate whether TTM at 33℃ is associated with better neurological outcomes in IHCA patients with nonshockable rhythm compared to targeted normothermia (37℃).
Article
Cardiac & Cardiovascular Systems
Ahmed A. Harhash, Teresa L. May, Chiu-Hsieh Hsu, Sachin Agarwal, David B. Seder, Michael R. Mooney, Nainesh Patel, John McPherson, Paul McMullan, Richard Riker, Eldar Soreide, Karen G. Hirsch, Pascal Stammet, Alison Dupont, Sten Rubertsson, Hans Friberg, Niklas Nielsen, Tanveer Rab, Karl B. Kern
Summary: This study analyzed the impact of each proposed unfavorable feature on survival to hospital discharge in successfully resuscitated cardiac arrest patients. Patients with 6 or more unfavorable features have a poor long-term prognosis, with <40% predicted survival if they have 3 or more unfavorable features.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Emergency Medicine
Motonori Takahagi, Hirotaka Sawano, Taiki Moriyama
Summary: This study evaluated the long-term neurological outcomes of extracorporeal cardiopulmonary resuscitation (ECPR) in patients with out-of-hospital cardiac arrest and initially nonshockable rhythms. The results showed that approximately 10% of patients achieved good neurological outcomes after receiving ECPR.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ryo Emoto, Mitsuaki Nishikimi, Muhammad Shoaib, Kei Hayashida, Kazuki Nishida, Kazuya Kikutani, Shinichiro Ohshimo, Shigeyuki Matsui, Nobuaki Shime, Taku Iwami
Summary: This study aimed to predict spontaneous rhythm change before hospital arrival in patients with out-of-hospital cardiac arrest. Seven factors were identified as predictors and a scoring system was developed and validated.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Critical Care Medicine
Min-Shan Tsai, Wen-Jone Chen, Wei-Ting Chen, Yu-Tzu Tien, Wei-Tien Chang, Hooi-Nee Ong, Chien-Hua Huang
Summary: This study aimed to evaluate the recovery status of cardiac arrest survivors and identify factors associated with delayed awakening. Results showed that a small percentage of patients recovered consciousness after the recommended 7-day observation period, indicating that a longer observation time may be needed.
CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Kei Hayashida, Ryosuke Takegawa, Yusuke Endo, Tai Yin, Rishabh C. Choudhary, Tomoaki Aoki, Mitsuaki Nishikimi, Atsushi Murao, Eriko Nakamura, Muhammad Shoaib, Cyrus Kuschner, Santiago J. Miyara, Junhwan Kim, Koichiro Shinozaki, Ping Wang, Lance B. Becker
Summary: This study demonstrates that mitochondrial transplantation can improve survival and neurological recovery in post-cardiac arrest rats. Freshly isolated functional mitochondria significantly increased the 72-hour survival rate and improved various aspects of cardiac and neurological functions. These findings provide a foundation for further research and development of mitochondrial transplantation as a novel therapeutic strategy.
Article
Critical Care Medicine
Eva M. Spoormans, Jorrit S. Lemkes, Gladys N. Janssens, Nina W. van der Hoeven, Lucia S. D. Jewbali, Eric A. Dubois, Martijn Meuwissen, Tom A. Rijpstra, Hans A. Bosker, Michiel J. Blans, Gabe B. Bleeker, Remon Baak, Georgios J. Vlachojannis, Bob J. W. Eikemans, Armand R. J. Girbes, Pim van der Harst, Iwan C. C. van der Horst, Michiel Voskuil, Joris J. van der Heijden, Albertus Beishuizen, Martin Stoel, Cyril Camaro, Hans van der Hoeven, Jose P. Henriques, Alexander P. J. Vlaar, Maarten A. Vink, Bas van den Bogaard, Ton A. C. M. Heestermans, Wouter de Ruijter, Thijs S. R. Delnoij, Harry J. G. M. Crijns, Gillian A. J. Jessurun, Pranobe Oemrawsingh, Marcel T. M. Gosselink, Koos Plomp, Michael Magro, Peter M. van de Ven, Niels van Royen, Paul W. G. Elbers
Summary: The optimal targeted temperature management strategy for patients with shockable rhythm is unclear. This study found that mild therapeutic hypothermia was not associated with improved 90-day survival compared with targeted normothermia in postarrest patients with initial shockable rhythm. Neurologic outcomes and patient-reported Mental and Physical Health Scores also did not differ between the two strategies at 90 days and 1 year.
CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Nilesh Pareek, Nicholas Beckley-Hoelscher, Ritesh Kanyal, Antonio Cannata, Peter Kordis, Nicholas Sunderland, Ali Kirresh, Joanne Nevett, Rachael Fothergill, Ian Webb, Rafal Dworakowski, Narbeh Melikian, Sundeep Kalra, Thomas W. Johnson, Gianfranco Sinagra, Serena Rakar, Marko Noc, Ajay M. Shah, Jonathan Byrne, Philip MacCarthy
Summary: This study evaluated the impact of performing immediate coronary angiography (CAG) after out-of-hospital cardiac arrest (OHCA) with stratification of predicted neurologic injury and cardiogenic shock on arrival to a center. The results showed that immediate CAG was associated with improved survival with good neurologic outcome in low-risk patients with ST-segment elevation myocardial infarction and SCAI grade B to E shock.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Jeffrey Che-Hung Tsai, Jen-Wen Ma, Shih-Chia Liu, Tzu-Chieh Lin, Sung-Yuan Hu
Summary: The CASPRI score can be used to predict survival and neurological outcomes in patients with EDCA, showing fair performance in predicting favorable neurological survival in successfully resuscitated patients. Post-cardiac arrest care may be beneficial for IHCA patients, especially those with EDCA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Jessica A. Barreto, Noel S. Weiss, Katie R. Nielsen, Reid Farris, Joan S. Roberts
Summary: This study aimed to evaluate the association between hyperoxia in the first 24 hours after in-hospital pediatric cardiac arrest and mortality and poor neurological outcome. The results showed that hyperoxia after pediatric cardiac arrest was common but was not associated with worse in-hospital outcomes.
Article
Medicine, General & Internal
Shir Lynn Lim, Yee How Lau, Mark Y. Chan, Terrance Chua, Huay Cheem Tan, David Foo, Zhan Yun Lim, Boon Wah Liew, Nur Shahidah, Desmond R. R. Mao, Si Oon Cheah, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Yih Yng Ng, Khung Keong Yeo, Marcus E. H. Ong
Summary: This study evaluated the association between early coronary angiography (CAG) and outcomes in resuscitated out-of-hospital cardiac arrest (OHCA) patients and found that early CAG with PCI was associated with better survival and neurological outcome. Further research is needed to identify the characteristics of patients who would benefit most from this invasive strategy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Vijay Agusala, Patrick Dale, Rohan Khera, Siobhan P. Brown, Ahamed H. Idris, Mark S. Link, Purav Mody
Summary: Multiple studies have provided conflicting results about the association between early coronary angiography (CAG) and out-of-hospital cardiac arrest (OHCA) patients. Meanwhile, the real-world patterns of CAG use among OHCA patients remain unclear.
Article
Biochemical Research Methods
Joanne T. DeKay, Teresa L. May, Richard R. Riker, Jonathan Rud, David J. Gagnon, Douglas B. Sawyer, David B. Seder, Sergey Ryzhov
Summary: The study showed that the number of CD26 expressing cells in the peripheral blood of COVID-19 patients is associated with disease severity and treatment outcomes. CD3(+)CD4(+) lymphocytes are the main cell type expressing CD26, and a low number of CD26 expressing cells is associated with critical disease, while an increasing number of CD26 expressing T cells during the first week of treatment is associated with good outcomes.
Article
Critical Care Medicine
Ameldina Ceric, Teresa L. May, Anna Lybeck, Tobias Cronberg, David B. Seder, Richard R. Riker, Christian Hassager, Jesper Kjaergaard, Zana Haxhija, Hans Friberg, Josef Dankiewicz, Niklas Nielsen
Summary: There is significant variation in sedation and analgesia dosing and titration between centers in international TTM trial, which are associated with delayed awakening, incidence of clinical seizures, and survival in patients. However, the causal relation of these findings cannot be proven.
NEUROCRITICAL CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Zana Haxhija, David B. Seder, Teresa L. May, Christian Hassager, Hans Friberg, Gisela Lilja, Ameldina Ceric, Niklas Nielsen, Josef Dankiewicz
Summary: The CREST model showed good validity and discrimination capability in predicting circulatory-etiology death after successfully resuscitating comatose patients without ST-segment-elevation myocardial infarction. The model provides a useful tool for triaging high-risk patients for transfer to specialized cardiac centers.
BMC CARDIOVASCULAR DISORDERS
(2023)
Review
Critical Care Medicine
Rachel Beekman, Karen G. G. Hirsch
Summary: Cardiac arrest survivors often suffer from consciousness disorders, and neuroimaging techniques such as CT and MRI are vital for predicting long-term neurological outcomes. Recent studies have explored qualitative and quantitative analysis methods, but further standardization is needed.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Pharmacology & Pharmacy
Aurora Quaye, Chelsea Wampole, Richard R. Riker, David B. Seder, William J. Sauer, Janelle M. Richard, Wendy Y. Craig, David J. Gagnon
Summary: The number of patients maintained on buprenorphine is increasing, but its management practices during critical illness and its relation to supplemental full-agonist opioid administration have not been studied. In this retrospective study, we found that continuing buprenorphine during critical illness was associated with decreased full-agonist opioid use. Lack of mechanical ventilation and acetaminophen use were also associated with buprenorphine use. These findings suggest the importance of considering buprenorphine continuation for patients with opioid use disorder during critical illness to reduce full-agonist opioid administration.
JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Editorial Material
Critical Care Medicine
Rachel Beekman, Karen G. Hirsch
Article
Clinical Neurology
Shefali Dujari, Janet Wei, Lironn Kraler, Tarini Goyal, Eric Bernier, Neil Schwartz, Karen Hirsch, Carl A. A. Gold
Summary: This study aimed to characterize the death outcomes of patients on inpatient neurology services and explore barriers to discharge to hospice. The results showed that some patients did not receive hospice care after death, and there were barriers to the discharge process. The study provides opportunities for further research and emphasizes the limitations of using in-hospital mortality as a quality indicator.
Article
Critical Care Medicine
Nicole M. Acquisto, Jarrod M. Mosier, Edward A. Bittner, Asad E. Patanwala, Karen G. Hirsch, Pamela Hargwood, John M. Oropello, Ryan P. Bodkin, Christine M. Groth, Kevin A. Kaucher, Angela A. Slampak-Cindric, Edward M. Manno, Stephen A. Mayer, Lars-Kristofer N. Peterson, Jeremy Fulmer, Christopher Galton, Thomas P. Bleck, Karin Chase, Alan C. Heffner, Kyle J. Gunnerson, Bryan Boling, Michael J. Murray
Summary: This interdisciplinary panel used evidence-based approach to develop a set of recommendations on pharmacologic and nonpharmacologic management for RSI.
CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Nicole M. Acquisto, Jarrod M. Mosier, Edward A. Bittner, Asad E. Patanwala, Karen G. Hirsch, Pamela Hargwood, John M. Oropello, Ryan P. Bodkin, Christine M. Groth, Kevin A. Kaucher, Angela A. Slampak-Cindric, Edward M. Manno, Stephen A. Mayer, Lars-Kristofer N. Peterson, Jeremy Fulmer, Christopher Galton, Thomas P. Bleck, Karin Chase, Alan C. Heffner, Kyle J. Gunnerson, Bryan Boling, Michael J. Murray
CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Jonathan Rud, Richard R. Riker, Ashley Eldridge, Christine Lord, Joanne T. deKay, Teresa L. May, David J. Gagnon, Douglas Sawyer, Sergey Ryzhov, David B. Seder
Summary: This pilot project aimed to assess the levels of soluble CD73 and soluble Adenosine Deaminase (ADA) in hospitalized COVID-19 patients and determine their association with disease severity. The results showed that the level of CD73 was directly correlated with the severity of the disease, including ICU admission, invasive ventilation, and hospital length of stay. Low levels of CD73 were also associated with clinical thrombosis, a severe complication of SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Editorial Material
Critical Care Medicine
David B. Seder
NEUROCRITICAL CARE
(2023)
Article
Critical Care Medicine
Brian L. Edlow, Varina L. Boerwinkle, Jitka Annen, Melanie Boly, Olivia Gosseries, Steven Laureys, Pratik Mukherjee, Louis Puybasset, Robert D. Stevens, Zachary D. Threlkeld, Virginia F. J. Newcombe, Davinia Fernandez-Espejo, Curing Coma Campaign
Summary: Advances in neuroimaging have provided insights into the mechanisms causing disorders of consciousness in patients with severe brain injuries. Neuroimaging techniques have improved diagnosis and prognosis, leading to endorsement of fMRI for clinical evaluation. However, standardized reporting is needed for research and collaboration.
NEUROCRITICAL CARE
(2023)
Meeting Abstract
Critical Care Medicine
Kaitlin Armstrong, Paige Weaver, Richard Riker, David Seder, David Gagnon
CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
Scott Bolesta, Kathryn Smith, Celine Gelinas, Marc Perreault, Lisa Burry, Rebekah Eadie, Federico Carini, Jamie Harpel, Ryan Stewart, Richard Riker, Brian Erstad
CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Karen G. Hirsch, Benjamin S. Abella, Edilberto Amorim, Mary Kay Bader, Jeffrey F. Barletta, Katherine Berg, Clifton W. Callaway, Hans Friberg, Emily J. Gilmore, David M. Greer, Karl B. Kern, Sarah Livesay, Teresa L. May, Robert W. Neumar, Jerry P. Nolan, Mauro Oddo, Mary Ann Peberdy, Samuel M. Poloyac, David Seder, Fabio Silvio Taccone, Anezi Uzendu, Brian Walsh, Janice L. Zimmerman, Romergryko G. Geocadin
Summary: The critical care management of patients after cardiac arrest lacks high-quality clinical studies and high-certainty evidence, leading to limited practice guideline recommendations. An expert consensus panel was organized to provide statements for clinicians on the critical care management of patients after cardiac arrest, addressing topics in various organ systems. However, more research is needed in many areas.
NEUROCRITICAL CARE
(2023)