Purification and characterization of an amyloidogenic repeat domain from the functional amyloid Pmel17

Cryo-EM structure of amyloid fibrils formed by the entire low complexity domain of TDP-43

(2021) Qiuye Li et al.   Nature Communications

Tryptophan Probes of TDP-43 C-Terminal Domain Amyloid Formation

(2021) Sydney O. Shuster et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17

(2020) Dexter N. Dean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hofmeister Ions Modulate the Autocatalytic Amyloidogenesis of an Intrinsically Disordered Functional Amyloid Domain via Unusual Biphasic Kinetics

(2020) Priyanka Dogra et al.   JOURNAL OF MOLECULAR BIOLOGY

Defining an amyloid link Between Parkinson’s disease and melanoma

(2020) Dexter N. Dean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pH-Dependent fibril maturation of a Pmel17 repeat domain isoform revealed by tryptophan fluorescence

(2019) Dexter N. Dean et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Raman fingerprints of amyloid structures

(2018) Jessica D. Flynn et al.   CHEMICAL COMMUNICATIONS

Why Study Functional Amyloids? Lessons from the Repeat Domain of Pmel17

(2018) Ryan P. McGlinchey et al.   JOURNAL OF MOLECULAR BIOLOGY

Lysophospholipids induce fibrillation of the repeat domain of Pmel17 through intermediate core-shell structures

(2018) Jannik Nedergaard Pedersen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Reversing the Amyloid Trend: Mechanism of Fibril Assembly and Dissolution of the Repeat Domain from a Human Functional Amyloid

(2017) Ryan P. McGlinchey et al.   ISRAEL JOURNAL OF CHEMISTRY

pH-Responsive Mechanistic Switch Regulates the Formation of Dendritic and Fibrillar Nanostructures of a Functional Amyloid

(2017) Priyanka Dogra et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles

(2015) Sven Hennig et al.   JOURNAL OF CELL BIOLOGY

Molecular Origin of pH-Dependent Fibril Formation of a Functional Amyloid

(2014) Ryan P. McGlinchey et al.   CHEMBIOCHEM

Lysophospholipid-Containing Membranes Modulate the Fibril Formation of the Repeat Domain of a Human Functional Amyloid, Pmel17

(2014) Zhiping Jiang et al.   JOURNAL OF MOLECULAR BIOLOGY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Probing Fibril Dissolution of the Repeat Domain of a Functional Amyloid, Pmel17, on the Microscopic and Residue Level

(2011) Ryan P. McGlinchey et al.   BIOCHEMISTRY

Segmental Polymorphism in a Functional Amyloid

(2011) Kan-Nian Hu et al.   BIOPHYSICAL JOURNAL

Repeat Domains of Melanosome Matrix Protein Pmel17 Orthologs Form Amyloid Fibrils at the Acidic Melanosomal pH

(2010) Ryan P. McGlinchey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17

(2010) C. M. Pfefferkorn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis

(2009) R. P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Electron tomography of early melanosomes: Implications for melanogenesis and the generation of fibrillar amyloid sheets

(2008) I. Hurbain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA