IP3R-driven increases in mitochondrial Ca2+ promote neuronal death in NPC disease
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
IP3R-driven increases in mitochondrial Ca2+ promote neuronal death in NPC disease
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 40, Pages e2110629118
Publisher
Proceedings of the National Academy of Sciences
Online
2021-09-28
DOI
10.1073/pnas.2110629118
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
- (2021) Mouhannad Malek et al. Nature Communications
- Structure and Function of IP3 Receptors
- (2019) David L. Prole et al. Cold Spring Harbor Perspectives in Biology
- Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability
- (2019) Oscar Vivas et al. Cell Reports
- Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity
- (2019) Scott A. Tiscione et al. JOURNAL OF CELL BIOLOGY
- The machineries, regulation and cellular functions of mitochondrial calcium
- (2018) Carlotta Giorgi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- IP3 receptor mutations and brain diseases in human and rodents
- (2017) Chihiro Hisatsune et al. JOURNAL OF NEUROCHEMISTRY
- Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
- (2017) Nagendra Babu Thillaiappan et al. Nature Communications
- Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis
- (2017) Wen-An Wang et al. Scientific Reports
- Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome
- (2016) Sylvie Gerber et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mutations in the IRBIT domain ofITPR1are a frequent cause of autosomal dominant nonprogressive congenital ataxia
- (2016) S. Barresi et al. CLINICAL GENETICS
- Dynamic formation of ER–PM junctions presents a lipid phosphatase to regulate phosphoinositides
- (2016) Eamonn J. Dickson et al. JOURNAL OF CELL BIOLOGY
- The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease
- (2016) Michael J. Berridge PHYSIOLOGICAL REVIEWS
- A Murine Niemann-Pick C1 I1061T Knock-In Model Recapitulates the Pathological Features of the Most Prevalent Human Disease Allele
- (2015) M. Praggastis et al. JOURNAL OF NEUROSCIENCE
- Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease
- (2015) Polina Egorova et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
- (2015) Feiran Lu et al. eLife
- Suppression of InsP3 Receptor-Mediated Ca2+ Signaling Alleviates Mutant Presenilin-Linked Familial Alzheimer's Disease Pathogenesis
- (2014) D. Shilling et al. JOURNAL OF NEUROSCIENCE
- Quantitative properties and receptor reserve of the IP3and calcium branch of Gq-coupled receptor signaling
- (2013) Eamonn J. Dickson et al. JOURNAL OF GENERAL PHYSIOLOGY
- IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice
- (2013) Chihiro Hisatsune et al. Frontiers in Neural Circuits
- The Probability of Triggering Calcium Puffs Is Linearly Related to the Number of Inositol Trisphosphate Receptors in a Cluster
- (2012) George D. Dickinson et al. BIOPHYSICAL JOURNAL
- Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release
- (2012) Dongbiao Shen et al. Nature Communications
- Role of Inositol 1,4,5-Trishosphate Receptors in Pathogenesis of Huntington’s Disease and Spinocerebellar Ataxias
- (2011) Ilya Bezprozvanny NEUROCHEMICAL RESEARCH
- Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria
- (2010) César Cárdenas et al. CELL
- Sequencing analysis of the ITPR1 gene in a pure autosomal dominant spinocerebellar ataxia series
- (2010) Joyce van de Leemput et al. MOVEMENT DISORDERS
- IP3 Receptors: Toward Understanding Their Activation
- (2010) C. W. Taylor et al. Cold Spring Harbor Perspectives in Biology
- Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+
- (2009) Taufiq-Ur-Rahman et al. NATURE
- Calcium hypothesis of Alzheimer’s disease
- (2009) Michael J. Berridge PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Calcium signaling and neurodegenerative diseases
- (2009) Ilya Bezprozvanny TRENDS IN MOLECULAR MEDICINE
- Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
- (2008) Emyr Lloyd-Evans et al. NATURE MEDICINE
- Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating
- (2008) King-Ho Cheung et al. NEURON
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started