Review
Biotechnology & Applied Microbiology
Kecheng Lou, Shangzhi Feng, Hui Luo, Junrong Zou, Guoxi Zhang, Xiaofeng Zou
Summary: Macrophages and their extracellular vesicles play significant roles in tumor microenvironment and cancer development, and show potential for clinical applications in immunomodulation, cancer therapy, infectious defense, and tissue repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Daniel E. Murphy, Olivier G. de Jong, Martijn J. W. Evers, Maratussholikhah Nurazizah, Raymond M. Schiffelers, Pieter Vader
Summary: RNA therapeutics have great potential, but face challenges in delivery to target cells. Extracellular vesicles (EVs) have emerged as promising RNA delivery vehicles with significantly higher delivery efficiency compared to synthetic systems.
Review
Immunology
Ke Lv, Yizhuo Wang, Peng Lou, Shuyun Liu, Pingya Zhou, Li Yang, Yanrong Lu, Jingqiu Cheng, Jingping Liu
Summary: Organ fibrosis is a global health challenge and current clinical treatments are inadequate. Native extracellular vesicles (EVs) have shown potential in alleviating fibrosis through various mechanisms, and their therapeutic potency can be enhanced through engineering strategies. This review provides insights into the development and translation of EV-based nanotherapies for clinical applications in the future.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Silvia Picciolini, Francesca Roda, Marzia Bedoni, Alice Gualerzi
Summary: Extracellular Vesicles (EVs) are naturally secreted nanoparticles with diverse functions and potential in diagnostics and therapeutics. Though their nanoscale dimensions have posed challenges, advancements in microtechnology and nanotechnology have accelerated research on EVs. Multidisciplinary knowledge exchange and efforts are crucial for further progress in EV research.
Article
Medicine, Research & Experimental
Han Wu, Hao Xing, Meng-Chao Wu, Feng Shen, Yu Chen, Tian Yang
Summary: This study utilized HCC-derived extracellular vesicles (EVs) as surface nanocarriers, applying sequential nanocatalysts GOD-ESIONs@EVs (GE@EVs) for tumor-specific and cascade nanocatalytic therapy against HCC. By enhancing intracellular endocytosis and generating highly toxic hydroxyl radicals in the mildly acidic tumor microenvironment, efficient apoptosis and necrosis of HCC cells were achieved.
Article
Biochemistry & Molecular Biology
Pawee Sitthichai, Setinee Chanpirom, Tharakorn Maneerat, Rawiwan Charoensup, Thapakorn Tree-Udom, Punyawatt Pintathong, Surat Laphookhieo, Tawanun Sripisut
Summary: This study evaluated the antibacterial and anti-inflammatory efficacy of black ginger extract in the treatment of acne. The results showed that black ginger extract had good inhibitory effects on Cutibacterium acnes and significantly reduced acne severity and erythema. This study demonstrates that black ginger extract could be an effective ingredient in anti-inflammatory and anti-acne products.
Article
Pharmacology & Pharmacy
Fumin Yuan, Ya-Min Li, Zhuhui Wang
Summary: Extracellular vesicles (EVs) are nanovesicles released by various cell types, known for their potent biological activities. While -80 degrees C is considered as the most favorable condition for storage, challenges remain in understanding the impact of storage conditions on EVs, indicating further research is needed.
Article
Oncology
Rajeswari Raguraman, Dhaval Bhavsar, Dongin Kim, Xiaoyu Ren, Vassilios Sikavitsas, Anupama Munshi, Rajagopal Ramesh
Summary: Exosomes are small vesicles that can be used as drug delivery vehicles for cancer treatment due to their unique characteristics. Preclinical studies have shown that exosomes can effectively deliver chemotherapeutics, biologicals, and natural products with potent anticancer activity. However, challenges in large-scale production, storage, and stability have limited the number of exosome-based clinical trials.
Review
Nanoscience & Nanotechnology
Zhiwei Jia, Shunxin Zhang, Wei Li
Summary: Degenerative bone disorders such as IVDD, OA, and OP present significant challenges for aging populations with no effective treatments available. The use of stem cell-derived EVs as a novel therapeutic approach holds promise in addressing these disorders. However, a comprehensive assessment of EV-based therapies in degenerative bone disorders is currently lacking. This review aims to fill this gap by summarizing the current state of the field and discussing the potential of EV-based treatments for IVDD, OA, and OP.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Shu Hua, Peter Mark Bartold, Karan Gulati, Corey Stephen Moran, Saso Ivanovski, Pingping Han
Summary: This review discusses the biogenesis of extracellular vesicles (EVs), particularly small EVs (sEVs) derived from periodontal and dental pulp cells, and their therapeutic potential. The study found that these EVs have various functions in vitro and in vivo, indicating a significant potential for regenerative applications.
Review
Pharmacology & Pharmacy
Yaqin Tang, Xingyou Liu, Meng Sun, Su Xiong, Nianting Xiao, Jianchao Li, Xiao He, Jing Xie
Summary: Extracellular vesicles (EVs) are small membrane-based vesicles that play a critical role in various physiological and pathological processes by serving as vehicles for intercellular communication. EVs have emerged as a promising cell-free therapy strategy for treating diseases, including cancer, due to their ability to transport various therapeutic molecules. Modifying or engineering EVs can improve their efficacy and specificity as drug carriers for cancer therapy. This review comprehensively outlines the biogenesis, isolation, and methodologies of EVs, as well as their biological functions, focusing on their specific applications as drug carriers in cancer therapy.
Review
Pharmacology & Pharmacy
Amanda Cano, Alvaro Munoz-Morales, Elena Sanchez-Lopez, Miren Ettcheto, Eliana B. Souto, Antonio Camins, Merce Boada, Agustin Ruiz
Summary: Neurodegenerative diseases have unknown etiology in many cases and lack effective treatments. The blood-brain barrier poses a challenge for drug delivery. Exosomes, secreted vesicles, have emerged as promising therapeutic tools due to their natural origin and molecular similarities. They are particularly promising for targeting neurodegenerative diseases due to the difficulty of accessing the brain and the complexity of the diseases.
Review
Biochemistry & Molecular Biology
Alexis German Murillo Carrasco, Andreia Hanada Otake, Janaina Macedo-da-Silva, Veronica Feijoli Santiago, Giuseppe Palmisano, Luciana Nogueira de Sousa Andrade, Roger Chammas
Summary: Breast cancer is the leading cause of tumor-related deaths in women worldwide, and there is a growing interest in molecular tools for early diagnosis and treatment. Extracellular vesicles (EVs) have emerged as potential reservoirs of signals for cell communication, and researchers have analyzed the cargoes of EVs derived from breast cancer to identify potential biomarkers and improve screening and treatment. This study provides a comprehensive list of potential markers categorized into different groups, and discusses the therapeutic potential and barriers to using EV-based tests in clinical settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Masaki Morishita, Maho Horita, Ayaka Higuchi, Maho Marui, Hidemasa Katsumi, Akira Yamamoto
Summary: Research on probiotic-derived extracellular vesicles (EVs) reveals their potential therapeutic applications, with similar particle sizes and zeta potentials among EVs secreted by different probiotics, and their ability to activate the host's immune response. Furthermore, these EVs are mainly taken up by immune cells through clathrin-mediated endocytosis and macropinocytosis, stimulating the immune system to produce inflammatory cytokines, indicating their potential as a novel adjuvant formulation.
MOLECULAR PHARMACEUTICS
(2021)
Article
Agricultural Engineering
Hong Luyen Le, Viet Hau Nguyen, Tien Dat Nguyen, Thi Van Anh Nguyen, Dang Huy Le
Summary: This study investigated the antiplatelet aggregation effect and anticoagulant activity of Kaempferia parviflora (KP) on human blood. The ethyl acetate fraction exhibited the strongest inhibitory effect on platelet aggregation and blood coagulation. Six known methoxyflavones were isolated from the extract, with compounds 2 and 3 showing stronger inhibitory effects. These findings suggest that KP is rich in potential antithrombotic agents.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Multidisciplinary Sciences
Sitthichai Kanokudom, Thachaporn Assawakongkarat, Yukihiro Akeda, Panan Ratthawongjirakul, Rungtip Chuanchuen, Nuntaree Chaichanawongsaroj
Summary: The study developed a lateral flow strip assay for rapid and simultaneous detection of multiple bla genes, showing a high prevalence of ESBL-producing E. coli in pork meat and fecal samples. The sensitivity and specificity of the assay were high, making it a promising tool for ESBL detection without the need for equipment.