Article
Engineering, Biomedical
X. Huang, D. He, Z. Pan, G. Luo, J. Deng
Summary: ROS can mediate various physiological functions, but their over-accumulation can lead to premature aging or death, as well as inflammatory conditions. Advances in nanoscience have led to the development of nanomaterials with unique ROS-scavenging abilities, allowing for the emergence of next-generation strategies to ameliorate ROS-related inflammatory conditions. Ongoing studies and clinical applications of nanomedicine based on ROS scavenging stand to benefit from this interdisciplinary field.
MATERIALS TODAY BIO
(2021)
Article
Biochemistry & Molecular Biology
Nerilson M. Lima, Gagan Preet, Sara R. Marqui, Thais de O. R. S. Falcoski, Geovana Navegante, Christiane P. Soares, Teresinha de Jesus A. S. Andrade, Felipe A. La Porta, Harinantenaina Liva R. Rakotondraie, Marcel Jaspars, Dulce H. S. Silva
Summary: This study evaluated the metabolic profiling and antigenotoxicity of Inga species with potential antitumor effects. It also used a proteomic approach to investigate the response of HepG2 cells to polyphenols isolated from I. laurina. The results showed cytotoxic activity against cancer cell lines and identified potential bioactive compounds. The proteomic analysis revealed proteins related to ROS elimination, DNA repair, tumor protein expression, and apoptosis.
Article
Agricultural Engineering
Jingze Sun, Jianan Wang, Yun Jia, Shujuan Zhuang, Yujiao Xie, Xiaoyan Yin, Yuan Zhang, Rongrong Zhao, Hongzi Tan, Lihong Wang, Feng Song, Hongyou Cui
Summary: This study investigated the free radical depolymerization of lignin using three model compounds and peroxymonosulfate (PMS). The results showed that the reaction pathway and selectivity of monomer products can be regulated by adjusting the pH value and temperature. The presence of hydroxyl and methoxy groups can enhance the reactivity of lignin model compounds and promote the directional generation of monomer products.
BIOMASS & BIOENERGY
(2023)
Article
Biotechnology & Applied Microbiology
Bosong Zhang, Yufang Zhao, Kai Guo, Hui Tian, Cao Wang, Ruiqi Wang, Yue Chen, Xiongbiao Chen, Hongxia Zheng, Bingxin Gao, Jieyi Shen, Weiming Tian
Summary: Prevention and early intervention are crucial in treating Alzheimer's disease (AD). This study investigates the use of nanoparticles composed of resveratrol and oligomeric proanthocyanidin grafted with hyaluronic acid to address the issue of ROS accumulation in early AD. The results demonstrate that these nanoparticles are effective in scavenging ROS, reducing brain inflammation, and improving cognitive function in AD mice.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Byulhana Kim, Young Kim, Yoonho Lee, Joomin Oh, Youngmee Jung, Won-Gun Koh, Justin J. Chung
Summary: Chronic wounds are difficult to repair due to continuous inflammatory response, which inhibits the normal wound healing mechanism. An antioxidant hydrogel has been developed to scavenge reactive oxygen species (ROS) and promote chronic wound healing.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Review
Biotechnology & Applied Microbiology
Muhammad Shafiq, Yujie Chen, Rashida Hashim, Chuanglong He, Xiumei Mo, Xiaojun Zhou
Summary: Reactive oxygen species (ROS) play essential roles in biological systems but can lead to oxidative stress, inflammation, and cellular damage when overexpressed. Modulating ROS levels through advanced biomaterials can promote tissue regeneration and enhance cellular activity and function.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Plant Sciences
P. Kumar, B. Singh, S. Rajak, S. Pandey, P. K. Pati
Summary: This study investigated the response of Withania somnifera to leaf spot disease caused by Alternaria alternata. It was found that the infected leaves showed increased NADPH oxidase activity and ROS accumulation, as well as enhanced antioxidant enzyme activity and lignin content. The expression of lignin biosynthesis genes and defence-related genes was also upregulated. This study provides insights into the defence mechanisms of W. somnifera against leaf spot disease.
Article
Agriculture, Multidisciplinary
Chunlu Qian, Zhengjie Ji, Yan Sun, Man Zhang, Juan Kan, Lixia Xiao, Jun Liu, Changhai Jin, Wenfei Yang, Xiaohua Qi
Summary: This study investigated the lignification of water bamboo shoots and found that lignin significantly accumulated in the epidermis of cold storage shoots. The up-regulated genes involved in lignin biosynthesis and MAPK signaling pathway suggested that lignification is regulated by RBOH-mediated ROS signaling.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Chunlu Qian, Zhengjie Ji, Yan Sun, Man Zhang, Juan Kan, Lixia Xiao, Jun Liu, Changhai Jin, Wenfei Yang, Xiaohua Qi
Summary: In this study, the accumulation of lignin and changes in the transcriptome of postharvested water bamboo shoots under cold storage were investigated. It was found that lignin significantly accumulated in the shoots and the major up-regulated genes were involved in phenylpropanoid biosynthesis, plant-pathogen interactions, and starch and sucrose metabolism. The MAPK signaling pathway and RBOH genes were also up-regulated. Inhibition of RBOH oxidase hindered lignin deposition and biosynthesis, while H2O2 enhanced these processes, indicating that lignification of water bamboo shoots is regulated by RBOH-mediated ROS signaling.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Stepan Sysak, Beata Czarczynska-Goslinska, Piotr Szyk, Tomasz Koczorowski, Dariusz T. Mlynarczyk, Wojciech Szczolko, Roman Lesyk, Tomasz Goslinski
Summary: Flavonoids are widely found in plants and have various medical applications. Combining flavonoids with nanocarriers can improve their bioavailability and create systems with wider functionalities. The conjugates of flavonoid-metal nanoparticles have unique physicochemical and biological properties, including improved selectivity towards target sites. Furthermore, flavonoids can also play a role in the initial step of metal nanomaterial preparation.
Article
Food Science & Technology
Moloya Gogoi, Jyoti L. Hati Boruah, Pranjit Kumar Bora, Deep Jyoti Das, Vanlalhruaii Famhawite, Anupam Biswas, Nusalu Puro, Jatin Kalita, Saikat Haldar, Rinku Baishya
Summary: The study demonstrated the inhibitory effect of Citrus macroptera peel extract on human non-small cell lung cancer cells through prooxidant induced apoptosis. CPEA was found to induce oxidative stress and mitochondrial membrane potential damage in A549 cells, resulting in cell death through apoptosis pathways.
Review
Biochemistry & Molecular Biology
Megumi Kishimoto-Urata, Shinji Urata, Chisato Fujimoto, Tatsuya Yamasoba
Summary: Oxygen metabolism in the mitochondria is crucial for biological activity, but it also produces reactive oxygen species (ROS) in cells. Imbalance between ROS production and degradation can lead to cell damage. Sensory organs, especially those for hearing, are constantly exposed and can cause hearing loss depending on the environment. Hair cells, spiral ganglion cells, and the stria vascularis in the auditory pathway, where mitochondria are abundant, are the main targets of ROS. Excessive ROS in auditory sensory organs are known to cause sensorineural hearing loss, and mitochondria-targeted antioxidants are potential treatments. This review focuses on the relationship between acquired hearing loss and antioxidant use, providing an overview of novel antioxidants, including medications, supplements, and natural foods, based on clinical, animal, and cell culture studies.
Article
Chemistry, Multidisciplinary
Yi-yang Lu, Shi-qing Li, Qing-zhong Lai, Lin-yan Wang, Wei-min Zhou, Cheng-long Hua, Dan-dan Ning, Chun-chun Zhang, Mei-ya Li, Fu-sheng Jiang
Summary: The tender leaves of Artemisia japonica Thumb. are commonly used in China as a vegetable and tea, as well as in traditional medicine. This study demonstrated the antioxidant and hepatic protective effects of a 60% ethanol extract of Artemisia japonica Thumb. leaves (AJLEE). The results suggest that AJLEE contains phenolic acids, flavonoids, and coumarins, which contribute to its antioxidant and hepatic protective properties.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Neurosciences
Javiera Gavilan, Daniela Mennickent, Oscar Ramirez-Molina, Sergio Trivino, Claudia Perez, Tiare Silva-Grecchi, Pamela A. Godoy, Jose Becerra, Luis G. Aguayo, Gustavo Moraga-Cid, Victoria San Martin, Gonzalo E. Yevenes, Patricio A. Castro, Leonardo Guzman, Jorge Fuentealba
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Virginia Casas-Arrojo, Juan Decara, Maria de los Angeles Arrojo-Agudo, Claudia Perez-Manriquez, Roberto T. Abdala-Diaz
Summary: Porphyridium cruentum's sulfated polysaccharides exhibit strong immunomodulatory and cytotoxic effects, inducing IL-6 cytokines and TNF-alpha. They show potential as a valuable ingredient in nutraceutical products.
Article
Biochemistry & Molecular Biology
Nina de Castro Jorge, Lubia M. Guedes, Narciso Aguilera, Jose Becerra, Rosy Mary dos Santos Isaias
Summary: This study investigated the allelopathic potential of different gall morphotypes of Eremanthus erythropappus on Lactuca sativa seeds. It was found that the pentacyclic triterpenes in the extracts of non-galled stems and stem galls had a strong allelopathic effect on seed germination. The galling activity also led to the synthesis and accumulation of new compounds while inhibiting the synthesis of previous compounds.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2022)
Article
Plant Sciences
Karina Andrea Crisostomo-Ayala, Ana Belen Sabater-Jara, Claudia Perez Manriquez, Federico Ferreres, Angel Gil-Izquierdo, Maria Angeles Pedreno, Martha Hernandez de la Torre, Manuel Sanchez-Olate, Darcy Graciela Rios Leal
Summary: This study identified various bioactive compounds in adult maqui leaves and compared them with leaves from in vitro-grown maqui plants. The results showed that the in vitro samples had higher total phenolic content, while winter basal leaves had higher total flavonoid content. The leaves of maqui plants could be a valuable source of antioxidants and lipophilic compounds for various industries.
Article
Chemistry, Medicinal
Fabian A. Figueroa, Roberto T. Abdala-Diaz, Claudia Perez, Virginia Casas-Arrojo, Aleksandra Nesic, Cecilia Tapia, Carla Duran, Oscar Valdes, Carolina Parra, Gaston Bravo-Arrepol, Luis Soto, Jose Becerra, Gustavo Cabrera-Barjas
Summary: This study aims to isolate and characterize the polysaccharide fractions from Codium bernabei, a green alga found on Chilean coasts. The extracted fractions were mainly composed of sulfated galactan unit and exhibited antioxidant, anticoagulant, and antitumor activities. The findings suggest the potential biotechnological application of sulfated galactan polysaccharides from Chilean marine resources.
Article
Plant Sciences
Lubia M. Guedes, Carolina Sanhueza, Solange Torres, Camilo Figueroa, Elvis Gavilan, Claudia I. Perez, Narciso Aguilera
Summary: Red galls induced by Eriophyes tiliae have high levels of anthocyanins and polyphenols, which contribute to their high antioxidant capacity in the high UV radiation environment of a Mediterranean climate. In contrast, non-galled leaves have higher photosynthetic pigment and protein contents. The results reveal the role of anthocyanins in the antioxidant protection of plant galls under high UV irradiance.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Plant Sciences
Lubia M. Guedes, Elvis Gavilan, Narciso Aguilera
Summary: This study explored the gall-inducing species Ophelimus migdanorum in Eucalyptus globulus plantations in Chile. The different inducer phenotypes induced galls on various organs of the plant. Regardless of the host organ and induction site, the galls were composed of a nutritive tissue surrounded by sclerenchyma cell layers. The host organ and induction microsites determined the composition of the outer gall cortex, and the various phenotypes of O. migdanorum were not associated with structural peculiarities of their galls.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Forestry
Lubia M. Guedes, Elvis Gavilan, Claudia Perez, Jose Becerra, Narciso Aguilera
Summary: This study shows that the gall-inducing insect Dasineura sp. can manipulate the structure and chemical composition of Peumusboldus stems to ensure its nutrition.
TREES-STRUCTURE AND FUNCTION
(2023)
Article
Chemistry, Medicinal
Virginia Casas-Arrojo, Maria de Los Angeles Arrojo Agudo, Casimiro Cardenas Garcia, Paloma Carrillo, Claudia Perez Manriquez, Eduardo Martinez-Manzanares, Roberto T. Abdala Diaz
Summary: The present study found that polysaccharides extracted from Euglena gracilis have anticancer activity, mainly targeting HCT-116 cells. These polysaccharides also have immunomodulatory capacity and antioxidant activity. Proteomic analysis identified five proteins that were considered to be overexpressed.
Article
Plant Sciences
L. M. Guedes, N. Aguilera, E. Gavilan, J. A. Pendola, N. E. Villagran
Summary: Certain chewing larvae, such as Dasineura sp., can induce gall formation in the vascular cylinder of host plants like Peumus boldus stems. A study was conducted to investigate the anatomical and functional implications of Dasineura sp. establishment on P. boldus stems, due to their medicinal and economic significance. The research aimed to determine if the presence of Dasineura sp. induces cellular and organizational abnormalities in the vascular system of P. boldus stems during gall development, which could contribute to the hydric status of the gall.
Article
Plant Sciences
Lorena Rodriguez-Cerda, Lubia M. Guedes, Solange Torres, Elvis Gavilan, Narciso Aguilera
Summary: The allelophatic effect of the invasive Fabaceae Ulex europaeus and Teline monspessulana on the production of phenolic compounds in C. alba seedlings was investigated. Both invasive species had an inhibitory effect on the growth and phenolic compound production of C. alba seedlings.
Article
Plant Sciences
Narciso Aguilera, Lubia M. Guedes, Ulises Alvarado, Katia Saez-Carrillo
Summary: Teline monspessulana, a highly invasive species, exerts allelochemical stress on the native Nothofagus obliqua, inhibiting its germination and growth and causing damage to its leaves and roots. This interdisciplinary study provides insight into the plant-plant relationship mediated by allelochemicals and can be replicated to investigate other interactions between invasive and native species.
Article
Agriculture, Multidisciplinary
Carolina Salazar, Felipe Landeros, Evelyn Bustos, Paulina Bravo, Claudia Perez, Jose Becerra, Darcy Rios, Matilde Uribe
CIENCIA E INVESTIGACION AGRARIA
(2019)
Article
Biochemistry & Molecular Biology
Yanru Feng, Muhammad Shahedul Alam, Feng Yan, Michael Frei
Summary: Tropospheric ozone has significant effects on the remobilization and allocation efficiency of aboveground biomass and nutrients in cereal crops. Long-term ozone exposure increases straw C:N ratio and affects grain C:N ratio. Grain N concentrations increase significantly under ozone stress, but N yield declines due to grain yield losses. Various indicators of N use efficiency are reduced, indicating reduced N absorption from soil and allocation from vegetative to reproductive organs. Straw C:N ratio is not suitable for predicting wheat productivity. Nitrogen harvest index (NHI) is not affected by ozone stress, but the relationship between harvest index (HI) and NHI is changed by elevated ozone concentration.
Article
Biochemistry & Molecular Biology
Cong Guan, Wei Li, Guoliang Wang, Ruimei Yang, Jinglei Zhang, Jinhong Zhang, Bo Wu, Run Gao, Chunlin Jia
Summary: This study characterized the expression profiles of mRNAs and ncRNAs in switchgrass under drought stress. The up-regulated mRNAs were enriched in starch and sucrose metabolism pathway, while the differentially expressed lncRNAs potentially regulated protein-coding genes. The study also constructed regulatory networks and validated the functionality of the target gene PvSS4 in enhancing drought tolerance.
Article
Biochemistry & Molecular Biology
Juan Nicolas-Espinosa, Lucia Yepes-Molina, Fuensanta Martinez-Bernal, Miriam Fernandez-Pozurama, Micaela Carvajal
Summary: This study aimed to investigate the physiological response of broccoli leaves to abiotic stresses such as salinity and boron toxicity/deficiency. The results showed that the combined stress of salinity and boron deficiency resulted in a significant reduction in plant biomass, and the adaptation mechanisms were associated with water and boron concentration in the leaves. The expression patterns of PIP aquaporins varied among the different stress treatments, and their presence in the plasma membrane and interaction with the lipid environment played potential regulatory roles in facilitating salinity-boron stress adaptation mechanisms.
Review
Biochemistry & Molecular Biology
Wen-Feng Huang, Juan Li, Jian-An Huang, Zhong-Hua Liu, Li-Gui Xiong
Summary: This review examines the seasonal trends of phyllosphere microorganisms in woody and herbaceous plants and explores the factors influencing these trends. While herbaceous and woody plants share some similarities and differences in their phyllosphere microbiomes, further experimental validation is needed.
Article
Biochemistry & Molecular Biology
Changguang Liao, Hui Shen, Zihan Gao, Yunshu Wang, Zhiguo Zhu, Qiaoli Xie, Ting Wu, Guoping Chen, Zongli Hu
Summary: The novel CRF, SlCRF6, plays a crucial role in regulating tomato plant morphology, leaf development, and the accumulation of photosynthetic products.
Article
Biochemistry & Molecular Biology
Alok Madhu, Alok Sharma, Amandeep Kaur, Kashmir Singh, Santosh Kumar Upadhyay
Summary: In this study, 15 TaMDHAR genes were identified in bread wheat and their crucial roles in antioxidants, growth and development, and stress responses were revealed.
Article
Biochemistry & Molecular Biology
Kai Zheng, Yongsheng Cai, Yanying Qu, Lu Teng, Chaoyue Wang, Jie Gao, Quanjia Chen
Summary: In this study, the whole genome identification and bioinformatics analysis of the HCT gene family were performed in G. barbadense. The results showed that the GbHCT114 gene regulates plant trichome development, which is closely related to cotton fiber quality. Gene silencing and overexpression experiments confirmed the important role of GbHCT114 gene in cotton fiber morphology, lignin content, and secondary xylem duct cell wall development. Transcriptomic analysis identified differentially expressed genes associated with lignin synthesis and fiber development.
Review
Biochemistry & Molecular Biology
Tanashvi Seth, Sejal Asija, Shahid Umar, Ravi Gupta
Summary: Plants activate a sophisticated signaling cascade in response to pests and pathogens, with lipids playing a crucial role in mediating these defense responses. Different types of lipids are involved in cell signaling during plant-pathogen interaction and each lipid has specific relevance and contributes to specific signaling cascades. Lipid biosynthetic enzymes, including phospholipases, are involved in the production of defense signaling molecules. Lipids participate in stress signaling by mediating signal transduction, acting as precursors for bioactive molecules, regulating ROS formation, and interacting with phytohormones.
Article
Biochemistry & Molecular Biology
Yangyang Chen, Xiao Wu, Xiaohua Wang, Qionghou Li, Hao Yin, Shaoling Zhang
Summary: 'Nanguo' pears emit a rich aroma when fully ripe, and the important volatile components are the six-carbon compounds derived from the lipoxygenase pathway. This study identified a highly expressed bZIP transcription factor that is induced during the mature stage of 'Nanguo' pears, and demonstrated its regulatory role in fatty acid-derived volatile biosynthesis.
Article
Biochemistry & Molecular Biology
Zhao Geng, Haikuan Dou, Jianguang Liu, Guiyuan Zhao, Linlin Liu, Ning Zhao, Hanshuang Zhang, Yongqiang Wang, Zetong An
Summary: The overexpression of GhFB15 gene decreases the salt tolerance of Arabidopsis plants, while silencing the gene improves the salt tolerance of cotton plants. Furthermore, GhFB15 regulates the accumulation of flavonoids and the levels of ROS.
Article
Biochemistry & Molecular Biology
Linjun Cai, Ancheng Ma, Jiao Lei, Chongsheng He
Summary: METTL4 is identified as a plant DNA 6mA methyltransferase in Arabidopsis thaliana and plays a crucial role in regulating heat stress response.
Article
Biochemistry & Molecular Biology
Zailong Tian, Kun Li, Yaru Sun, Baojun Chen, Zhaoe Pan, Zhenzhen Wang, Baoyin Pang, Shoupu He, Yuchen Miao, Xiongming Du
Summary: Plants have evolved a mechanism called 'stress memory' to survive in various environmental stresses. This study reveals the physiological, biochemical, and molecular mechanisms underlying drought stress memory formation in cotton, highlighting the role of histone modification H3K4me3 in regulating transcriptional memory. It also investigates the intergenerational inheritance of drought stress memory in cotton, providing theoretical guidance for cotton breeding.