Article
Engineering, Biomedical
Jiang-Shan Gong, Guo-Qiang Zhu, Yu Zhang, Bei Chen, Yi-Wei Liu, Hong-Ming Li, Ze-Hui He, Jing-Tao Zou, Yu-Xuan Qian, Sheng Zhu, Xin-Yue Hu, Shan-Shan Rao, Jia Cao, Hui Xie, Zhen-Xing Wang, Wei Du
Summary: This study developed a novel BMSC-aptamer functionalized hydrogel and demonstrated its effectiveness in recruiting BMSCs and promoting bone regeneration.
MATERIALS TODAY BIO
(2023)
Article
Cell Biology
Yun Bai, Tao Yu, Jiezhong Deng, Yusheng Yang, Jiulin Tan, Qijie Dai, Zehua Zhang, Shiwu Dong, Jianzhong Xu
Summary: Research shows that CTGF secreted by TRAP-positive monocytes activates PSCs during bone regeneration, promoting bone healing; CTGF enhances PSC renewal by upregulating multiple pluripotent genes; Additionally, CTGF activates Smad3 through αVβ5 integrin, which is crucial for chondrogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Laura Doherty, Matthew Wan, Anna Peterson, Daniel W. Youngstrom, Justin S. King, Ivo Kalajzic, Kurt D. Hankenson, Archana Sanjay
Summary: Despite the regenerative capacity of skeletal tissues, the failure of bone to heal properly is a significant clinical concern. Lgr6 has been implicated in tissue regeneration, but its role in bone healing is unclear. In this study, we found that Lgr6 is dynamically expressed in osteo-progenitors in response to fracture injury. Using an Lgr6-null mouse model, we discovered that Lgr6 expression is necessary for maintaining bone volume and efficient postnatal bone regeneration. Skeletal progenitors isolated from Lgr6-null mice exhibited reduced differentiation capacity and impaired signaling pathways. These findings suggest that Lgr6-positive cells play a direct role in endochondral bone repair.
Review
Endocrinology & Metabolism
Xiaofeng Wang, Fanyuan Yu, Ling Ye
Summary: Recent studies have shown that MSCs play a vital role in bone regeneration, including osteogenic differentiation and providing seed cells. However, factors like drug intake and body senescence can affect MSCs' functions in bone regeneration. Epigenetic regulation has received attention for its heritable nature and involvement in bone metabolism disorders. This review focuses on the effects of epigenetic regulation on osteogenic differentiation, proliferation, and cellular senescence in MSCs and its role in bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Physical
Mindaugas Pranskunas, Egidijus Simoliunas, Milda Alksne, Victor Martin, Pedro Sousa Gomes, Algirdas Puisys, Algirdas Kaupinis, Gintaras Juodzbalys
Summary: The study evaluated the functionality of secretome isolated from periosteum-derived MSCs in healing critical size calvarial bone defects in rabbits, showing that osteogenic-induced secretome enhanced new bone formation process and had the highest bone tissue formation. The findings suggest that MSC secretome, particularly from osteogenic-induced populations, may be an effective therapeutic approach to enhance bone tissue healing and regeneration.
Article
Biochemistry & Molecular Biology
Yundong Peng, Jingjing Du, Stefan Gunther, Xinyue Guo, Shengpeng Wang, Andre Schneider, Li Zhu, Thomas Braun
Summary: Skeletal muscle stem cells, also known as satellite cells, play a crucial role in postnatal muscle growth and regeneration. This study reveals that Piezo1, a mechanosensitive ion channel, is essential for maintaining the quiescence and preventing senescence of muscle stem cells. Absence of Piezo1 leads to premature activation of these cells, impairs their proliferation and differentiation, and significantly hinders skeletal muscle regeneration. The inactivation of Piezo1 results in compensatory up-regulation of T-type voltage-gated Ca2+ channels, which increases the influx of Ca2+ and induces NOX4 expression through cPKC. The elevated expression of NOX4 in Piezo1-deficient cells leads to increased levels of reactive oxygen species (ROS) and DNA damage, causing P53-dependent cellular senescence and cell death. The study also highlights the importance of the P53/P21-axis in mediating the cellular defects caused by the absence of Piezo1. This research sheds light on the critical role of Piezo1-mediated mechano-signaling in maintaining the quiescence and preventing senescence of muscle stem cells, and suggests that reduced mechano-signaling during aging may contribute to the accumulation of senescent cells and the decline of muscle stem cell numbers in geriatric individuals.
Article
Biochemistry & Molecular Biology
Esther Laguna, Maria Isabel Perez-Nunez, Alvaro del Real, Guillermo Menendez, Jose A. Sainz-Aja, Laura Lopez-Delgado, Carolina Sanudo, Alicia Martin, Remigio Mazorra, Diego Ferreno, Belen Garcia-Montesinos, Jose A. Riancho
Summary: This study analyzed the regenerative capacity of MSCs in the treatment of fractures and found that MSCs from patients with osteoarthritis had an inhibitory effect on consolidation, while MSCs from patients with osteoporosis compared favorably.
Article
Pharmacology & Pharmacy
Yoshitaka Iso, Sayaka Usui, Hiroshi Suzuki
Summary: The aim of this study was to investigate the pro-angiogenic potential of skeletal muscle mesenchymal stem/stromal cells (mMSCs). The results showed that PDGFR-alpha positive mMSCs secreted VEGF and hepatocyte growth factor, inducing endothelial tube formation and promoting capillary growth. Epo stimulation enhanced phosphorylation and cellular proliferation in mMSCs, leading to improved perfusion recovery and capillary growth in the ischemic limbs.
Article
Biochemistry & Molecular Biology
Martina Sandona, Federica Esposito, Anna Cargnoni, Antonietta Silini, Pietro Romele, Ornella Parolini, Valentina Saccone
Summary: This study demonstrates that the secretome and extracellular vesicles derived from mesenchymal stromal cells from the amniotic membrane (hAMSCs) can promote muscle regeneration by stimulating proliferation and differentiation of muscle stem cells. It also shows that these factors can modulate the muscle stem cell niche and reduce fibrosis and muscle exhaustion. These findings suggest a potential novel treatment for Duchenne muscular dystrophy (DMD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yujing Cao, Qiuxia Lv, Yang Li
Summary: Astragaloside IV (AST-IV) promotes bone regeneration in tibial defects in rats through the miR-124-3p.1/STAT3 axis, enhancing proliferation and osteogenic differentiation of human bone marrow mesenchymal stromal/stem cells (hBMSCs).
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biology
Shuo Huang, Min Jin, Nan Su, Lin Chen
Summary: Bone has a strong regenerative capacity driven by reparative cells such as skeletal stem cells and their descendants, playing critical roles in bone development, maintenance, and injury healing. However, the identity and functional roles of skeletal stem cells remain controversial due to technological difficulties and cell heterogeneity. There has been a biased view for many years that bone marrow is the main source of reparative cells for bone repair.
BIOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Korin Sahinyan, Felicia Lazure, Darren M. Blackburn, Vahab D. Soleimani
Summary: This review discusses the factors and effects of declining numbers and regenerative potential of muscle stem cells (MuSCs) during aging, and emphasizes the importance of understanding these changes for developing effective therapies for age-related muscle defects.
Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Medicine, General & Internal
Dionysios J. Papachristou, Stavros Georgopoulos, Peter Giannoudis, Elias Panagiotopoulos
Summary: Fracture-healing is a complex process that may fail, leading to delayed unions or non-unions. Research and clinical studies are focusing on unraveling the mechanisms regulating fracture-healing, aiming to develop more effective therapeutic strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yulia Suzdaltseva, Sergey L. Kiselev
Summary: Scar formation during normal tissue regeneration in adults can have negative effects on appearance and function. Fetal tissues, on the other hand, are capable of complete regeneration. Understanding the cellular and molecular mechanisms of fetal wound regeneration can lead to successful treatments for minimizing scarring. However, limited access to fetal material hinders research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Theodoros H. Tosounidis, Colin Holton, Vasileios P. Giannoudis, Nikolaos K. Kanakaris, Robert M. West, Peter V. Giannoudis
Summary: Study investigated correlation between elevated CRP and WBC levels in nonunion patients, finding elevated CRP levels increased infection risk. WBC count unreliable for predicting infection. All cases achieved solid union post-revision surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michalis Panteli, Marilena P. Giannoudi, Christopher J. Lodge, Robert M. West, Ippokratis Pountos, Peter V. Giannoudis
Summary: This study aimed to define the incidence of subtrochanteric femoral fractures and investigate associations with mortality and medical complications following intramedullary nail treatment. Risk factors for mortality included low albumin, dementia, pneumonia, and high Charlson comorbidity score. Factors such as ICU/HDU stay, asthma/COPD, and prolonged hospital stay were associated with higher incidence of hospital acquired pneumonia. Early identification of these factors could aid in prognostication and prevention of poor outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Tobias Russell, Abdulla Watad, Charlie Bridgewood, Hannah Rowe, Almas Khan, Abhay Rao, Peter Loughenbury, Peter Millner, Robert Dunsmuir, Richard Cuthbert, Ala Altaie, Elena Jones, Dennis McGonagle
Summary: The study found that spinal enthesis contains MSCs with different in vitro functionalities, especially in response to IL-17A. IL-17A enhances osteogenesis and CCL20 production, while reducing adipogenesis.
Review
Medicine, General & Internal
Dionysios J. Papachristou, Stavros Georgopoulos, Peter Giannoudis, Elias Panagiotopoulos
Summary: Fracture-healing is a complex process that may fail, leading to delayed unions or non-unions. Research and clinical studies are focusing on unraveling the mechanisms regulating fracture-healing, aiming to develop more effective therapeutic strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michalis Panteli, James S. H. Vun, Robert M. West, Anthony Howard, Ippokratis Pountos, Peter V. Giannoudis
Summary: This study aimed to investigate the incidence, risk factors and pathogenic microorganisms causing infection in patients with subtrochanteric femoral fractures managed with an intramedullary nail. Deep infection was associated with non-union, open fracture, massive transfusion, post-operative transfusion and prolonged length of stay. Staphylococcus aureus and coliforms were the most common microorganisms identified in superficial and deep infections, respectively, with polymicrobial infection present in a significant proportion of cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michalis Panteli, James S. H. Vun, Robert M. West, Anthony J. Howard, Ippokratis Pountos, Peter V. Giannoudis
Summary: This study developed and validated a predictive model for non-union following subtrochanteric fractures of the femur. By identifying risk factors and creating a risk score, high-risk patients can be identified early post-operatively. The scoring system demonstrated good discriminatory capability, calibration, and internal validity, providing valuable information for surgeons to intervene and modify surgery-related factors to reduce the risk of non-union.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Angelos Kaspiris, Argyris C. Hadjimichael, Elias S. Vasiliadis, Dionysios J. Papachristou, Peter V. Giannoudis, Elias C. Panagiotopoulos
Summary: This study investigated the clinical implantation of growth factors for intraoperative enhancement of osteogenesis in the treatment of long bone fractures and non-unions. The results showed that the application of BMP-2 and -7, PRP, and MSCs significantly increased the effectiveness of fracture treatment and postoperative functional scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Payal Ganguly, Nicolas Fiz, Maider Beitia, Heather E. Owston, Diego Delgado, Elena Jones, Mikel Sanchez
Summary: This study investigated the effects of combined intraosseous and intraarticular PRP treatment on subchondral bone mesenchymal stromal cells (MSCs) in osteoarthritis (OA) patients. The results showed that PRP treatment enhanced the proliferative and stress-resistance capacities of subchondral MSCs, particularly in older patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
James Tebby, Vasileios P. Giannoudis, Sophia M. Wakefield, Fiona Lecky, Omar Bouamra, Peter V. Giannoudis
Summary: Managing patients with multiple injuries, especially those with comorbidities such as diabetes mellitus, remains challenging and increases mortality. This study investigates the impact of major trauma centres in the UK on the outcomes of polytrauma patients with diabetes. The findings show that while overall mortality has decreased, patients with diabetes still had higher mortality compared to other groups, highlighting diabetes as an independent risk factor for mortality in polytrauma patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Lemiha Yildizbakan, Neelam Iqbal, Payal Ganguly, Eric Kumi-Barimah, Thuy Do, Elena Jones, Peter V. V. Giannoudis, Animesh Jha
Summary: To address bone damage-related complications, highly porous chitosan scaffolds were engineered with iron-doped dicalcium phosphate dihydrate minerals and different concentrations of cerium oxide nanoparticles. The scaffolds exhibited altered physicochemical properties and enhanced antibacterial characteristics with increasing cerium oxide concentrations. They showed promising potential for tissue regeneration, mitigating infection risks, and inhibiting bacterial growth, while exhibiting negligible cytotoxic effects.
Article
Biotechnology & Applied Microbiology
James Vun, Neelam Iqbal, Elena Jones, Payal Ganguly
Summary: Aging and age-related changes have negative effects on elderly individuals, including decreased movement and cognitive abilities, as well as increased vulnerability to age-related diseases. Cellular senescence, triggered by DNA damage response, is a key factor contributing to these changes. Senescent cells release harmful substances that cause inflammation and contribute to age-related diseases. Platelet-rich plasma (PRP) has shown potential in combating senescence and inflammation, as well as promoting tissue regeneration, making it a promising option for anti-aging and tissue regeneration strategies.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Payal Ganguly, Jehan J. El-Jawhari, James Vun, Peter V. Giannoudis, Elena A. Jones
Summary: In this study, the ability of a biomorphic B-HA scaffold to support human bone marrow-derived mesenchymal stromal cells (BMSCs) was investigated. The results showed that the B-HA scaffold could effectively support BMSC attachment and survival, and BMSCs had a unique gene expression profile compared to culture-expanded MSCs. Furthermore, co-culturing human endothelial cells on the B-HA scaffold led to increased VEGF release, suggesting a potential mechanism for providing vasculature to the repair area.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Nancy M. S. Hussein, Josie L. Meade, Hemant Pandit, Elena Jones, Reem El-Gendy
Summary: Periodontitis and diabetes mellitus have adverse interactions, with current periodontal therapies having uncertain outcomes in diabetic patients. Periodontal tissue engineering is a promising approach that focuses on using stem cells and signaling molecules to restore periodontal tissues. Research on characterizing MSCs from diabetic patients aims to enhance tissue regeneration using autologous stem cells.
BIOENGINEERING-BASEL
(2021)
Review
Biotechnology & Applied Microbiology
Jehan J. El-Jawhari, Payal Ganguly, Elena Jones, Peter Giannoudis
Summary: This review discusses the application of bone marrow-derived mesenchymal stromal cells in treating osteonecrosis, including donor-related factors, the impact of aging on donor-related variability, and factors influencing the quantity and function of these cells.
BIOENGINEERING-BASEL
(2021)
Article
Critical Care Medicine
Andrija Jurina, Valentina Delimar, Zlatko Giljevic, Tajana Filipec Kanizaj, Andro Matkovic, Dinko Vidovic, Nikolina Jurjevic, Vinko Vidjak, Zeljko Duic, Mario Cuk, Mladen Japjec, Tomislav Dujmovic, Andrea Radeljak, Mirjana Marjana Kardum Paro, Marijana Vucic-Lovrencic, Mario Staresinic
Summary: This study investigated the prevalence of fragility spinal fractures among liver transplant candidates with cirrhosis. The results showed the detrimental impact of chronic liver disease and hepatic osteodystrophy on bone strength, and the correlation between DXA measurement and lumbar fragility fractures. These findings highlight the importance of adequate bone evaluation in liver transplant candidates.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
M. Scrivano, A. Vadal, G. Fedeli, R. Di Niccolo, D. Topa, S. Porcino, F. Pallotta, A. De Carli
Summary: This study compares the outcomes and complications of Ilioinguinal versus modified Stoppa approach in Open Reduction and Internal Fixation (ORIF) of anterior column acetabulum fractures. The results show that the modified Stoppa approach has a shorter operative time, less intra-operative blood loss, and fewer complications. The ilioinguinal approach achieves better anatomic reduction. However, there were no significant differences in terms of vascular lesions, clinical and functional outcomes between the two groups.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Jacob Hartline, Christopher T. Cosgrove, Nathan N. O'Hara, Qasim M. Ghulam, Zachary D. Hannan, Robert V. O'Toole, Marcus F. Sciadini, Christopher G. Langhammer
Summary: In a young, healthy orthopedic trauma population with isolated extremity injury, traditional demographic factors and ballistic injury mechanism have a greater predictive value for long-term mortality after hospital discharge compared to popular markers of socioeconomic status.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Youngmin Kwon, Jihye Lim, Chunui Lee
Summary: This study aims to investigate dental traumatic injuries related to standing electric scooters and compare them with injuries caused by other factors. The results indicate that crown-root fractures and avulsions are more common in electric scooter accidents. Additionally, relatively minor dental injuries, such as concussions and subluxations, are more likely to occur as combined injuries in electric scooter accidents. The study suggests the need for strengthened policies and enforcement of laws to prevent severe dental and craniofacial trauma associated with electric scooter use.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Louise Kruse Jensen, Henrik Elvang Jensen, Hans Gottlieb
Summary: This study describes the histopathology of debrided bone tissue in chronic osteomyelitis (CO). The inflammatory response still exists after debridement, although it fades from the center. Sampling of debrided bone tissue must be performed initially during surgery to avoid underestimation of neutrophil infiltration.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Alejandro Alejandrez, Motasem Refaat, Yeng Vue
Summary: This study aims to assess the rate of operative fixation of sacral fractures in pelvises with dysmorphic and nondysmorphic sacrums, as well as whether a difference exists in fracture morphology between groups. The study found no statistical difference in operative fixation rates between pelvises with dysmorphic and nondysmorphic sacrums, but a difference in fracture patterns was observed.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Dong Wang, Shuo Diao, Xiaobin Zhou, Junlin Zhou, Yang Liu
Summary: This study discussed the role of fracture site tissue exosomes lncRNAs-mRNAs networks on post-injury adaptation (PIA) promoting bone mesenchymal stem cells (BMSCs) proliferation and migration. The results confirmed that PIA accelerated BMSCs proliferation and migration, and identified tissue exosomes as the key factor in this process. By analyzing the tissue exosomes lncRNAs-mRNAs networks, several hub genes, such as Akt1, Actb, and Uba52, were identified, and Kif11 was found to be a key gene in BMSCs regulated by tissue-derived exosomes of PIA treated rats.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Lisa Reider, Jason R. Falvey, Safiyyah M. Okoye, Jennifer L. Wolff, Joseph F. Levy
Summary: Falls are a leading cause of injury and hospital readmissions in older adults, with over 3 million seeking hospital care for fall injuries annually in the United States. The annual acute treatment costs for these injuries amount to $20 billion, indicating the urgent need for evidence-based fall prevention interventions and investments in geriatric emergency departments.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Mohamed Elbuzidi, Alyssa N. Wenzel, Andrew Harris, Majd Marrache, Julius K. Oni, Harpal S. Khanuja, Vishal Hegde
Summary: A retrospective propensity score matched cohort study was conducted using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database to compare outcomes for patients with recently diagnosed COVID-19 infection and those without COVID-19 infection undergoing operative treatment of hip fractures. The results showed that COVID-19-positive patients had a higher risk of 30-day mortality, pneumonia, unplanned intubation, septic shock, longer length of hospital stay, and discharge to an acute care hospital. Active COVID-19 infection is an independent risk factor for complications and increased resource utilization in these patients.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Jorge Mayor, Vera Birgel, Jan-Dierk Clausen, Goekmen Aktas, Stephan Sehmisch, Ann-Kathrin Einfeldt, Vasilis Giannoudis, Ahmed H. K. Abdelaal, Emmanouil Liodakis
Summary: This study provides a comprehensive overview of biomechanical research on the treatment of intertrochanteric fractures using cephalomedullary devices. Through a systematic literature search and synthesis analysis, the study highlights the need for standardization in biomechanical studies, and suggests strategies to enhance construct stability. The findings emphasize the importance of further research and meta-analyses to establish standardized protocols and enhance reliability.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Patricia Rodarte, Jamieson O'Marr, Billy Haonga, Deogratias Patrick, Kian Niknam, Mayur Urva, Abigail Cortez, Willem-Jan Metsemakers, David Shearer, Saam Morshed
Summary: This study evaluates the diagnostic performance of telephone questionnaires in identifying patients with fracture-related infections (FRIs) after open tibia fracture fixation in Tanzania. The study shows that telephone questionnaires have adequate diagnostic performance, with drainage being the main indicator for FRIs.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Zhiyi Liu, Guodong Hou, Wencong Zhang, Junyan Lin, Jinrong Yin, Huan Chen, Guowei Huang, Aiguo Li
Summary: Calcaneal tuberosity avulsion fracture, an extra-articular injury, is a rare fracture caused internally by intense contraction of the gastrocnemius-soleus complex, and externally by low-energy (possibly high-energy). The risk of injuries to the skin and Achilles tendon around the calcaneal tuberosity is closely related to the Lee classification and Carnero-Martin de Soto Classification of this type of fracture. Diagnosis is typically confirmed through X-ray, digital imaging, and CT, but MRI should also be used to assess the soft tissue. Recent advances in understanding this fracture have led to the development of different internal fixation devices and surgical procedures that provide stable fracture reduction and resistance to Achilles tendon forces. This article reviews the new insights into the anatomy, classification, risk factors, and treatment modalities of calcaneal tuberosity avulsion fracture in recent years.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Win Wah, Janneke Berecki-Gisolf, Karen Walker-Bone
Summary: This study aimed to identify the incidence and factors associated with in-hospital complications of work-related musculoskeletal injuries. The results showed that age, gender, area-level disadvantage, hospital type, comorbidity, emergency admissions, anesthesia, and the type of injury were all associated with in-hospital complications. The most common complications were cardiovascular, gastrointestinal complications and adverse drug events.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Gareth Rooke, Paul Sharplin, Richard Buckley
Summary: A 31-year-old female suffered a right fibula fracture with deltoid ligament injury after falling while climbing on wet rocks. She had ORIF surgery and recovered well, but has developed vague pain and hardware sensation at the lateral ankle 6 months later. Her past medical history includes breast reduction surgery and vaginal delivery, and she has a social history of alcohol consumption and past recreational drug use.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Yuwei Wen, Danjiang Zhu, Qiang Wang, Baojian Song, Wei Feng
Summary: This study compared the clinical outcomes of compression screw and non-weight-bearing techniques in treating pediatric Jones fractures. The results showed that compared to non-weight-bearing techniques, compression screw fixation can shorten the radiographic union time, immobilization time, and facilitate earlier return to full weight bearing and daily life. We recommend the use of compression screw fixation for widely displaced fractures and school-age active adolescents.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)