IL-17A and TNF Modulate Normal Human Spinal Entheseal Bone and Soft Tissue Mesenchymal Stem Cell Osteogenesis, Adipogenesis, and Stromal Function

Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis

(2020) Eric Gracey et al.   Nature Reviews Rheumatology

Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression

(2020) Abdulla Watad et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of entheseal IL-23 expression by IL-4 and IL-13 as an explanation for arthropathy development under dupilumab therapy

(2020) Charlie Bridegwood et al.   RHEUMATOLOGY

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis

(2019) Alexander Rauch et al.   NATURE GENETICS

Identification of myeloid cells in the human enthesis as the main source of local IL-23 production

(2019) Charlie Bridgewood et al.   ANNALS OF THE RHEUMATIC DISEASES

What constitutes the fat signal detected by MRI in the spine of patients with ankylosing spondylitis? A prospective study based on biopsies obtained during planned spinal osteotomy to correct hyperkyphosis or spinal stenosis

(2019) Xenofon Baraliakos et al.   ANNALS OF THE RHEUMATIC DISEASES

Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths

(2019) Samuel L. Wolock et al.   Cell Reports

The Analysis of In Vivo Aging in Human Bone Marrow Mesenchymal Stromal Cells Using Colony-Forming Unit-Fibroblast Assay and the CD45lowCD271+ Phenotype

(2019) Payal Ganguly et al.   Stem Cells International

Evidence that tissue resident human enthesis γδT-cells can produce IL-17A independently of IL-23R transcript expression

(2019) Richard James Cuthbert et al.   ANNALS OF THE RHEUMATIC DISEASES

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system

(2019) Tanja Hyvärinen et al.   Scientific Reports

Vertebral body versus iliac crest bone marrow as a source of multipotential stromal cells: Comparison of processing techniques, tri-lineage differentiation and application on a scaffold for spine fusion

(2018) Evangelos M. Fragkakis et al.   PLoS One

Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage

(2018) Yusuke Ogata et al.   Regenerative Therapy

Sera of patients with axial spondyloarthritis (axSpA) enhance osteoclastogenic potential of monocytes isolated from healthy individuals

(2018) Mariusz Korkosz et al.   BMC MUSCULOSKELETAL DISORDERS

Anti-IL-17 monoclonal antibodies for the treatment of ankylosing spondylitis

(2018) Daniel Wendling et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis

(2018) Isabelle Cambré et al.   Nature Communications

IL-17A Inhibition Diminishes Inflammation and New Bone Formation In Experimental Spondyloarthritis

(2018) Melissa N. van Tok et al.   Arthritis & Rheumatology

The Early Phases of Ankylosing Spondylitis: Emerging Insights From Clinical and Basic Science

(2018) Abdulla Watad et al.   Frontiers in Immunology

Role of Stem Cells in Pathophysiology and Therapy of Spondyloarthropathies—New Therapeutic Possibilities?

(2017) Magdalena Krajewska-Włodarczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brief Report: Group 3 Innate Lymphoid Cells in Human Enthesis

(2017) Richard J. Cuthbert et al.   Arthritis & Rheumatology

Osteoimmunology in Bone Fracture Healing

(2017) Takehito Ono et al.   Current Osteoporosis Reports

Visualization of lipid directed dynamics of perilipin 1 in human primary adipocytes

(2017) Jesper S. Hansen et al.   Scientific Reports

Proinflammatory T cells and IL-17 stimulate osteoblast differentiation

(2016) Michiel Croes et al.   BONE

Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts

(2016) Özge Uluçkan et al.   Science Translational Medicine

IL-17-producing γδ T cells enhance bone regeneration

(2016) Takehito Ono et al.   Nature Communications

Mesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis

(2016) T. Mark Campbell et al.   Arthritis & Rheumatology

Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression

(2015) Xiuli Wang et al.   Stem Cell Research

Efficacy of TNFα blockers in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a meta-analysis

(2014) Johanna Callhoff et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-17 inhibits osteoblast differentiation and bone regeneration in rat

(2014) Yong-Gun Kim et al.   ARCHIVES OF ORAL BIOLOGY

Interleukin-17 enhances immunosuppression by mesenchymal stem cells

(2014) X Han et al.   CELL DEATH AND DIFFERENTIATION

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

(2014) T. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Effects of Interleukin-17A on Osteogenic Differentiation of Isolated Human Mesenchymal Stem Cells

(2014) Bilal Osta et al.   Frontiers in Immunology

Secretion of immunoregulatory cytokines by mesenchymal stem cells

(2014) Dobroslav Kyurkchiev   World Journal of Stem Cells

Continuous long-term anti-TNF therapy does not lead to an increase in the rate of new bone formation over 8 years in patients with ankylosing spondylitis

(2013) Xenofon Baraliakos et al.   ANNALS OF THE RHEUMATIC DISEASES

Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells

(2013) Peggy Jacques et al.   ANNALS OF THE RHEUMATIC DISEASES

Assay validation for the assessment of adipogenesis of multipotential stromal cells—a direct comparison of four different methods

(2013) Andrew Aldridge et al.   CYTOTHERAPY

Transcriptional profile of native CD271+ multipotential stromal cells: Evidence for multiple fates, with prominent osteogenic and Wnt pathway signaling activity

(2012) Sarah M. Churchman et al.   ARTHRITIS AND RHEUMATISM

Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: Implication to age-associated bone diseases and defects

(2012) MiJung Kim et al.   MECHANISMS OF AGEING AND DEVELOPMENT

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

(2012) Jonathan P Sherlock et al.   NATURE MEDICINE

High abundance of CD271+ multipotential stromal cells (MSCs) in intramedullary cavities of long bones

(2011) George Cox et al.   BONE

Adipogenesis at a glance

(2011) C. E. Lowe et al.   JOURNAL OF CELL SCIENCE

IL-17 Regulates Adipogenesis, Glucose Homeostasis, and Obesity

(2010) L. A. Zuniga et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

The fatty Romanus lesion: a non-inflammatory spinal MRI lesion specific for axial spondyloarthropathy

(2009) A. N. Bennett et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes

(2009) Jennifer H. Shin et al.   BIOCHEMICAL PHARMACOLOGY

The role of Dickkopf-1 in bone development, homeostasis, and disease

(2008) J. J. Pinzone et al.   BLOOD