Chemical constituents and anti-inflammatory activity of the total alkaloid extract from Melodinus cochinchinensis (Lour.) Merr. and its inhibition of the NF-κB and MAPK signaling pathways

HRESIMS-guided isolation of aspidosperma-scandine type bisindole alkaloids from Melodinus cochinchinensis and their anti-inflammatory and cytotoxic activities

(2021) Fang-Ru Li et al.   PHYTOCHEMISTRY

Activation of the NF-κB and MAPK Signaling Pathways Contributes to the Inflammatory Responses, but Not Cell Injury, in IPEC-1 Cells Challenged with Hydrogen Peroxide

(2020) Kan Xiao et al.   Oxidative Medicine and Cellular Longevity

In vitro and in vivo anti-inflammatory effects of different extracts from Epigynum auritum through down-regulation of NF-κB and MAPK signaling pathways

(2020) Meilian Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Targeted isolation of terpenoid indole alkaloids from Melodinus cochinchinensis (Lour.) Merr. using molecular networking and their biological activities

(2020) Fangru Li et al.   INDUSTRIAL CROPS AND PRODUCTS

Identification and characterization of potential antioxidant components in Isodon amethystoides (Benth.) Hara tea leaves by UPLC-LTQ-Orbitrap-MS

(2020) Hong Duan et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-inflammatory effects of dicaffeoylquinic acids from Ilex kudingcha on lipopolysaccharide-treated RAW264.7 macrophages and potential mechanisms

(2019) Peng Wan et al.   FOOD AND CHEMICAL TOXICOLOGY

EtOAc extract of H. attenuatum Choisy inhibits inflammaion by suppressing the NF-κB and MAPK pathways and modulating the gut microbiota

(2019) Du-Xin Jin et al.   PHYTOMEDICINE

Liquiritin from Glycyrrhiza uralensis Attenuating Rheumatoid Arthritis via Reducing Inflammation, Suppressing Angiogenesis, and Inhibiting MAPK Signaling Pathway

(2019) Ke-feng Zhai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

An Algal Metabolite-Based PPAR-γ Agonist Displayed Anti-Inflammatory Effect via Inhibition of the NF-κB Pathway

(2019) Zhiran Ju et al.   Marine Drugs

Phenolic constituents, antioxidant and cytoprotective activities of crude extract and fractions from cultivated artichoke inflorescence

(2019) Meilian Yang et al.   INDUSTRIAL CROPS AND PRODUCTS

Alkaloids for cancer prevention and therapy: Current progress and future perspectives

(2019) Arijit Mondal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibitory Effects of Gynura procumbens Ethanolic Extract on Nitric Oxide Production and Inducible Nitric Oxide Synthase (iNOS) Protein Expression in Macrophages

(2019) Jiah Ning Tan et al.   Sains Malaysiana

Monoterpenoid indole alkaloids from the fruits of Melodinus henryi

(2019) Qian Shao et al.   Phytochemistry Letters

Delavatine A, an unusual isoquinoline alkaloid exerts anti-inflammation on LPS-induced proinflammatory cytokines production by suppressing NF-κB activation in BV-2 microglia

(2018) Qing Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination

(2018) Depeng Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Alkaloids from Melodinus henryi with anti-inflammatory activity

(2018) Jin-Qian Yu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

The new plant Parinari kerstingii Engl.: Toxicity studies and anti-inflammatory properties

(2018) Loveth O. Linus et al.   JOURNAL OF ETHNOPHARMACOLOGY

Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo

(2018) Cai-Lan Li et al.   PHYTOMEDICINE

Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model

(2018) Eun-A Kim et al.   Journal of Functional Foods

Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways

(2017) Han-bin Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vitro and in vivo assessment of anti-inflammatory and immunomodulatory activities of Xylaria nigripes mycelium

(2017) Rupesh D. Divate et al.   Journal of Functional Foods

Protective effects of paeonol on inflammatory response in IL-1β-induced human fibroblast-like synoviocytes and rheumatoid arthritis progression via modulating NF-κB pathway

(2017) Ke-feng Zhai et al.   INFLAMMOPHARMACOLOGY

Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways

(2016) Hongqian Chu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Melaxillines A and B, monoterpenoid indole alkaloids from Melodinus axillaris

(2016) Lei Fang et al.   FITOTERAPIA

Characterization of chemical constituents and rats metabolites of an alkaloidal extract of Alstonia scholaris leaves by liquid chromatography coupled with mass spectrometry

(2016) Jing Cao et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Zhikang Capsule ameliorates dextran sodium sulfate-induced colitis by inhibition of inflammation, apoptosis, oxidative stress and MyD88-dependent TLR4 signaling pathway

(2016) Liang Fei et al.   JOURNAL OF ETHNOPHARMACOLOGY

Phytochemical and Pharmacological Properties of the Genus Melodinus – A Review

(2016) Jin-He Jiang et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

(2015) Milla Kibble et al.   NATURAL PRODUCT REPORTS

Anti-inflammatory effect of litsenolide B2 isolated from Litsea japonica fruit via suppressing NF-κB and MAPK pathways in LPS-induced RAW264.7 cells

(2015) Young-Min Ham et al.   Journal of Functional Foods

Cepharanthine, an Alkaloid from Stephania cepharantha Hayata, Inhibits the Inflammatory Response in the RAW264.7 Cell and Mouse Models

(2013) Hailong Huang et al.   INFLAMMATION

Progress of pharmacological studies on alkaloids from Apocynaceae

(2012) Lu Liu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010

(2011) Augusto Lopes Souto et al.   MOLECULES

Pharmacological evaluation of Alstonia scholaris: Anti-inflammatory and analgesic effects

(2010) Jian-Hua Shang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent

(2010) Scharri J. Ezell et al.   Marine Drugs

Total alkaloids from Radix Linderae prevent the production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells by suppressing NF-κB and MAPKs activation

(2009) Yubin Luo et al.   CYTOKINE

Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE2, and pro-inflammatory cytokines production via the down-regulation of NF-κB in RAW 264.7 murine macrophage cells

(2009) Kyung-Jin Yun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melodinines A−G, Monoterpenoid Indole Alkaloids fromMelodinus henryi

(2009) Tao Feng et al.   JOURNAL OF NATURAL PRODUCTS

Melohenines A and B, Two Unprecedented Alkaloids fromMelodinus henryi

(2009) Tao Feng et al.   ORGANIC LETTERS

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE