Review
Biochemistry & Molecular Biology
Alessandro Zucchi, Francesco Claps, Antonio Luigi Pastore, Alessandro Perotti, Andrea Biagini, Luana Sallicandro, Rosaria Gentile, Concetta Caglioti, Federico Palazzetti, Bernard Fioretti
Summary: Bladder cancer is a common urinary system tumor, especially in males. Surgery and intravesical instillations can eliminate it, but recurrences and progression are frequent. Therefore, adjuvant therapy should be considered. Resveratrol has shown potential as an adjuvant therapy for bladder cancer, with anti-proliferative effects at high concentrations and anti-angiogenic action at low concentrations. This review examines the standard therapeutic approach to bladder cancer, preclinical studies on resveratrol in bladder cancer xenotransplantation models, and discusses molecular signals, particularly the STAT3 pathway and angiogenic growth factor modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Tao Ma, Yan Chen, Zhi-Gang Yi, Jia Liu, Yan-Hong Li, Jun Bai, Wen-Ting Tie, Mei Huang, Xiao-Feng Zhu, Ji Wang, Juan Du, Xiu-Qin Zuo, Qin Li, Fan-Li Lin, Liu Tang, Jing Guo, Hong-Wen Xiao, Qian Lei, Xiao-Li Ma, Li-Juan Li, Lian-Sheng Zhang
Summary: This study reveals that NORAD acts as an oncogene in multiple myeloma and exerts its effects through the BMP6/P-ERK1/2 axis. Knockdown of NORAD promotes apoptosis and induces cell cycle arrest, while inhibiting cell proliferation in multiple myeloma.
CELLULAR SIGNALLING
(2022)
Article
Oncology
Ning Huang, Lei Peng, Jiaping Yang, Jinqian Li, Sheng Zhang, Mingjuan Sun
Summary: This study found that FAM111B gene is overexpressed in bladder cancer and is associated with lymphatic metastasis and reduced overall survival. Knockdown of FAM111B gene can inhibit cell proliferation and migration, induce apoptosis, and suppress tumor growth.
Review
Oncology
Yong Xia, Ruijiao Chen, Guangzhen Lu, Changlin Li, Sen Lian, Taek-Won Kang, Young Do Jung
Summary: Phytochemicals derived from plants have shown promising anticancer activities, some of which have been developed into first-line anticancer drugs. However, their specific applications in bladder cancer therapy are limited. Summarizing the mechanism of action of phytochemicals in bladder cancer could contribute to the development of new anticancer drugs and treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jingjing Pan, Xiaojuan Xie, Jinxiu Sheng, Chenxi Ju, Shuaijie Sun, Fangfang Cui, Wen Zhai, Liang Ming
Summary: The study identified differentially expressed lncRNAs, circRNAs, miRNAs, and mRNAs in gemcitabine-resistant/sensitive bladder cancer cells, revealing regulatory networks that may underlie chemoresistance mechanisms. Functional analysis confirmed the roles of specific ceRNA networks in gemcitabine-resistant bladder cancer, providing a foundation for future biomarker and therapeutic target discovery.
Article
Multidisciplinary Sciences
AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghamir
Summary: This study demonstrates that MSC-exosomes have certain anti-tumor effects on prostate, bladder, and kidney cancer cells. These effects are mainly achieved by inducing apoptosis and inhibiting cancer cell proliferation.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Ying-Si Wu, Jar-Yi Ho, Cheng-Ping Yu, Chun-Jung Cho, Chia-Lun Wu, Cheng-Shuo Huang, Hong-Wei Gao, Dah-Shyong Yu
Summary: The study demonstrated that TGF-beta/Smad-induced EMT contributes to GCB resistance in bladder cancer by reducing GCB influx, and elucidated the novel mechanisms of ellagic acid-mediated inhibition of TGF-beta/Smad-induced EMT to overcome GCB resistance. The findings suggest further investigation of ellagic acid as an effective therapeutic adjuvant agent for overcoming GCB resistance in bladder cancer.
Article
Oncology
Yang Dong, Wei-ming Ma, Zhen-duo Shi, Zhi-guo Zhang, Jia-he Zhou, Yang Li, Shao-qi Zhang, Kun Pang, Bi-bo Li, Wen-da Zhang, Tao Fan, Guang-yuan Zhu, Liang Xue, Rui Li, Ying Liu, Lin Hao, Cong-hui Han
Summary: Bladder urothelial carcinoma (BC) is a deadly malignancy, and Neuropilin-1 (NRP1) has been found to be highly expressed in BC tissues and cells. Knockdown of NRP1 promotes apoptosis and inhibits proliferation, angiogenesis, migration, and invasion of BC cells, potentially serving as a new therapeutic target for BC treatment. Additionally, NRP1 affects various biological functions through MAPK signaling and cancer pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Zhiqi Zhang, Haitao Yu, Wenyan Yao, Na Zhu, Ran Miao, Zhiquan Liu, Xuwei Song, Chunhua Xue, Cheng Cai, Ming Cheng, Ke Lin, Dachuan Qi
Summary: This study reveals that RRP9 plays a critical role in inducing gemcitabine chemoresistance in pancreatic cancer through the activation of the IGF2BP1/AKT signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Medicine, Research & Experimental
Catarina Alves-Vale, Ana Maria Capela, Carlota Tavares-Marcos, Beatriz Domingues-Silva, Bruno Pereira, Francisco Santos, Carla Pereira Gomes, Guadalupe Espadas, Rui Vitorino, Eduard Sabido, Paula Borralho, Sandrina Nobrega-Pereira, Bruno Bernardes de Jesuse
Summary: The recently discovered lncRNA NORAD is induced after DNA damage in a p53-dependent manner and it plays a critical role in maintaining genomic stability. NORAD is upregulated in several types of cancer, including breast cancer, and high NORAD expression levels are associated with poor prognosis. In this study, it was found that downregulation of NORAD sensitizes triple-negative breast cancer cells to chemotherapy.
MOLECULAR THERAPY NUCLEIC ACIDS
(2023)
Article
Oncology
Xiangui Meng, Wen Xiao, Jiayin Sun, Weiquan Li, Hongwei Yuan, Tiexi Yu, Xiaoping Zhang, Wei Dong
Summary: In this study, we identified a novel upregulated circRNA, circPTK2, that regulates bladder cancer (BCa) metastasis and chemoresistance by modulating SETDB1 expression. Through transcriptome analysis, we identified PABPC1 as a novel interacting protein of circPTK2. Our experimental results demonstrated that circPTK2 enhances PABPC1's ability to stabilize SETDB1 mRNA, leading to increased SETDB1 expression and facilitated epithelial-mesenchymal transition (EMT). Functionally, overexpression of the circPTK2-SETDB1 axis promoted migration, invasion, and gemcitabine resistance in vitro and enhanced lymph node metastasis in vivo in BCa cells.
Article
Oncology
Motoki Tamai, Shuichi Tatarano, Shunsuke Okamura, Wataru Fukumoto, Issei Kawakami, Yoichi Osako, Takashi Sakaguchi, Satoshi Sugita, Masaya Yonemori, Yasutoshi Yamada, Masayuki Nakagawa, Hideki Enokida, Hirofumi Yoshino
Summary: MiR-99a-5p induces cellular senescence in gemcitabine-resistant bladder cancer cells by targeting SMARCD1, thereby inhibiting cell growth and restoring sensitivity to gemcitabine.
MOLECULAR ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xu Zhang, Hao Xiong, Yong Zhao, Shengqiang Lin, Xiang Huang, Cheng Lin, Shihui Mao, Demin Chen
Summary: This research identifies the circLONP2/miR-584-5p/YAP1 axis as a novel regulatory module in the progression of bladder cancer. The study shows that circLONP2 plays an oncogenic role by regulating the miR-584-5p/YAP1 axis, and targeting this interaction could be a potential strategy for treating bladder cancer.
Review
Biotechnology & Applied Microbiology
Eun Hye Lee, Hyun Tae Kim, So Young Chun, Jae-Wook Chung, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Eun Sang Yoo, Tae Gyun Kwon, Tae-Hwan Kim, Yun-Sok Ha
Summary: Given the high morbidity and poor prognosis of bladder cancer, understanding and studying the signaling pathways and related mechanisms in bladder cancer is of great significance for the exploration of new treatment strategies.
ONCOTARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Congfei Wang, Heguang Huang
Summary: The study investigated the role of hnRNP D in resistance to gemcitabine in pancreatic cancer cells, revealing that decreased hnRNP D expression promoted cell apoptosis induced by GEM.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biotechnology & Applied Microbiology
Qinrong Ping, Ruping Yan, Xin Cheng, Wenju Wang, Yiming Zhong, Zongliu Hou, Yunqiang Shi, Chunhui Wang, Ruhong Li
Summary: Tumors are a leading cause of death in humans, and developing safe and effective methods for early diagnosis and treatment is crucial. The tumor microenvironment (TME) plays a key role in regulating tumor behavior, with cancer-associated fibroblasts (CAFs) being important regulators. However, the heterogeneity and functions of CAFs present challenges in research and treatment.
CANCER GENE THERAPY
(2021)
Correction
Biotechnology & Applied Microbiology
Qinrong Ping, Ruping Yan, Xin Cheng, Wenju Wang, Yiming Zhong, Zongliu Hou, Yunqiang Shi, Chunhui Wang, Ruhong Li
CANCER GENE THERAPY
(2021)
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)