Article
Genetics & Heredity
Yoshiaki Shinden, Tadahiro Hirashima, Nijiro Nohata, Hiroko Toda, Reona Okada, Shunichi Asai, Takako Tanaka, Yuto Hozaka, Takao Ohtsuka, Yuko Kijima, Naohiko Seki
Summary: Our recent research identified certain passenger strands of miRNAs that function as tumor-suppressive miRNAs in cancer cells, and analyzed the miRNA expression signature of breast cancer (BrCa) to identify oncogenic genes controlled by pre-miR-99a. The study revealed FAM64A as a potential target and highlighted the importance of aberrant expression of FAM64A in the malignant transformation of BrCa.
JOURNAL OF HUMAN GENETICS
(2021)
Article
Agriculture, Multidisciplinary
Peng Yang, Qing Lian, Rong Fu, Guo-bin Ding, Sajid Amin, Zongwei Li, Zhuoyu Li
Summary: Cucurbitacin E (CE) induces cellular senescence in colorectal cancer (CRC) cells by attenuating the expression of the transcription factor TFAP4. This finding presents potential therapeutic opportunities for CRC.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pathology
Yang Yang, Guoying Zhang, Jian Li, Rui Gong, Yingbao Wang, Yang Qin, Qinrong Ping, Libing Hu
Summary: The study revealed that NORAD is highly expressed in GEM-resistant BC cells and its knockdown inhibits cell proliferation and enhances sensitivity to GEM. The findings suggest that NORAD may serve as a therapeutic target for BC GEM resistance.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Ke Wang, Xunliang Jiang, Yu Jiang, Jun Liu, Yongtao Du, Zecheng Zhang, Yunlong Li, Xinhui Zhao, Jipeng Li, Rui Zhang
Summary: This study revealed the role of the EZH2/miR-139-5p/TOP2A axis in regulating cellular senescence and cell proliferation in HCC, enriching the molecular mechanisms of EZH2-mediated epigenetic regulation in HCC. Therapeutically targeting EZH2 to induce cellular senescence and destroy senescent cells could be a potential treatment strategy for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Liu
Summary: The study demonstrates that high expression of KCNQ1OT1 in bladder cancer promotes tumor progression by regulating the miR-218-5p/HS3ST3B1 signaling pathway.
CANCER GENE THERAPY
(2021)
Article
Medicine, General & Internal
Edyta M. Borkowska, Piotr Kutwin, Dorota Rolecka, Tomasz Konecki, Maciej Borowiec, Zbigniew Jablonowski
Summary: The study aimed to evaluate the clinical utility of miR-19a-3p and miR-99a-5p as diagnostic markers in non-invasive bladder cancer. Real-time PCR was used to assess the expression of microRNA. The results showed that miR-19a-3p and miR-99a-5p were significantly altered in bladder cancer samples and could serve as diagnostic markers.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Dingyuan Zhang, Yuting Li, Yiting Lei, Haiqing Yang, Linying Huang, Xue Chen, Zhihao Zhou, Cuiyi Huang, Yantao Zhou, Ruolan Feng, Xing-Dong Xiong, Yuan Yuan, Hongjing Cui, Hui-Ling Zheng, Xuerong Sun, Xinguang Liu, Shun Xu
Summary: Circular RNA circRNF169 is up-regulated in senescent mouse embryonic fibroblasts (MEFs). Silencing circRNF169 delays cell senescence and promotes cell proliferation, while overexpression of circRNF169 has the opposite effects. CircRNF169 acts as a sponge for miR-30c-5p, accelerating cellular senescence. These results indicate that circRNF169 plays a crucial role in cellular senescence and may serve as a potential target for aging intervention.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Mohammad Waseem, Himali Gujrati, Bi-Dar Wang
Summary: In this study, the researchers investigated the role of the miR-99b-5p/mTOR/AR/SMARCD1 signaling axis in African American (AA) prostate cancer (PCa) aggressiveness. They found that nuclear mTOR, AR, and SMARCD1 were highly expressed in AA PCa cells compared to European American (EA) PCa cells. miR-99b-5p inhibited the protein levels of mTOR, AR/AR-V7, and SMARCD1 in the cytoplasm and nuclei of both EA and AA PCa cells, and effectively inhibited cell proliferation/survival and induced cell apoptosis. Additionally, the combination of miR-99b-5p and enzalutamide synergistically enhanced cytotoxicity against aggressive AA PCa and castration-resistant prostate cancer (CRPC).
FRONTIERS IN ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yidong Cheng, Hao Yu, Kai Li, Jiancheng Lv, Juntao Zhuang, Kexin Bai, Qikai Wu, Xiao Yang, Haiwei Yang, Qiang Lu
Summary: Accumulating evidence has shown that hsa_circ_0003098 plays a vital role in bladder cancer (BCa). The overexpression of hsa_circ_0003098 is associated with poor prognosis and promotes BCa cell proliferation, migration, invasion, and tumor growth. Mechanistically, hsa_circ_0003098 acts as a sponge for miR-377-5p, promoting the upregulation of ACAT2 expression and inducing cholesteryl ester accumulation. Therefore, hsa_circ_0003098 could serve as a potential biomarker and therapeutic target for BCa.
Article
Biochemistry & Molecular Biology
Hui Huang, Xia Li, Xianlin Zhang, Zhiqiang Li, Duo Han, Wenzhe Gao, Ling Liu, Cheng Peng, Hongwei Zhu, Xiao Yu
Summary: The DSCR9/miR-21-5p/BTG2 axis regulates the proliferation, invasion, and gemcitabine resistance of pancreatic cancer.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Huyan Ting, Lina Gao, Na Gao, Chaochao Wang, Wuli Guo, Xiaojie Zhou, Qi Li
Summary: Bladder cancer impairs NK cell function and immune surveillance through exosomes. Specific miRNAs in exosomes may interfere with gene stability in NK cells and can be potential targets for BC therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yuan Chen, Shiben Ji, Jianxin Ying, Yongchang Sun, Jun Liu, Guohong Yin
Summary: This study identifies a novel biomarker, KRT6A, for early diagnosis of bladder tumors and reveals its role in promoting bladder tumor progression. Additionally, it uncovers the regulatory axis of KRT6A/miR-31-5p in bladder tumor growth.
Article
Cell Biology
Xuan Ma, Tian Fu, Zhi-Yin Ke, Shen-Lin Du, Xue-Chun Wang, Ning Zhou, Mu-Yi Zhong, Yong-Jun Liu, Ai-Ling Liang
Summary: The study aimed to investigate the regulatory roles of the miR-17-5p/RRM2 axis in gemcitabine resistance in A549/G+ cells. Cell viability was assessed using CCK8 and clonogenic assays. Gene expression levels were analyzed by RT-qPCR and Western blotting. Cell cycle analysis was performed using flow cytometry. The results showed that up-regulating miR-17-5p expression reduced drug resistance and altered cell cycle distribution in gemcitabine-resistant cells. Down-regulating miR-17-5p had the opposite effects in gemcitabine-sensitive cells. The miR-17-5p/RRM2 axis could potentially regulate gemcitabine resistance in A549 cells through the p-PTEN/PI3K/AKT signaling pathway.
Article
Cell Biology
Maristella Canovai, Monica Evangelista, Alberto Mercatanti, Romina D'Aurizio, Letizia Pitto, Francesca Marrocolo, Valentina Casieri, Marco Pellegrini, Vincenzo Lionetti, Sergio Bracarda, Milena Rizzo
Summary: In this study, we found that miR-96-5p, miR-183-5p, and miR-210-3p released by DCT resistant PCa clones decrease the efficacy of DCT in PCa cells. These miRNAs were found to interact with genes including FOXO1, IGFBP3, PDCD4, PPP2CB, and INSIG1, affecting the sensitivity of DCT. Additionally, circulating miR-183-5p and miR-21-5p were identified as potential biomarkers for predicting DCT resistance in PCa patients.
CELL DEATH DISCOVERY
(2023)
Article
Veterinary Sciences
Aparna Hebbar, Rajeev Chandel, Payal Rani, Suneel Kumar Onteru, Dheer Singh
Summary: This study aimed to evaluate the potential of miRNAs as estrus biomarkers in buffalo, finding that certain miRNAs showed altered levels in different estrous cycle phases, while others were undetected in buffalo urine. Future studies should further explore the biomarker potential of miR-99a-5p in a larger cohort.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Oncology
Kazuki Kuroshima, Hirofumi Yoshino, Shunsuke Okamura, Masafumi Tsuruda, Yoichi Osako, Takashi Sakaguchi, Satoshi Sugita, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida
Article
Oncology
Hirofumi Yoshino, Hideki Enokida, Yoichi Osako, Nijiro Nohata, Masaya Yonemori, Satoshi Sugita, Kazuki Kuroshima, Masafumi Tsuruda, Shuichi Tatarano, Masayuki Nakagawa
MOLECULAR ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Masafumi Tsuruda, Hirofumi Yoshino, Shunsuke Okamura, Kazuki Kuroshima, Yoichi Osako, Takashi Sakaguchi, Satoshi Sugita, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida
Article
Immunology
Yasutoshi Yamada, Hideki Enokida, Hiroki Harada, Saiki Saito, Taichi Miyauchi, Shuji Nagatomi, Masato Minami, Akihiko Mitsuke, Tomoaki Ishihara, Hiroaki Nishimura, Shuichi Tatarano, Norihiko Goto, Yuichi Akasaki, Masayuki Nakagawa
TRANSPLANTATION PROCEEDINGS
(2020)
Article
Multidisciplinary Sciences
Hirofumi Yoshino, Yasutoshi Yamada, Hideki Enokida, Yoichi Osako, Masafumi Tsuruda, Kazuki Kuroshima, Takashi Sakaguchi, Satoshi Sugita, Shuichi Tatarano, Masayuki Nakagawa
Article
Oncology
Shunsuke Okamura, Hirofumi Yoshino, Kazuki Kuroshima, Masafumi Tsuruda, Yoichi Osako, Takashi Sakaguchi, Masaya Yonemori, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida
Summary: The study established cisplatin-resistant BC cell lines and identified miR-486-5p as a tumor suppressor microRNA that targets EHHADH gene, affecting cancer cell proliferation, migration, invasion, and cisplatin sensitivity.
Article
Oncology
Katsuhiro Ito, Takashi Kobayashi, Takahiro Kojima, Kensuke Hikami, Takeshi Yamada, Kosuke Ogawa, Kenji Nakamura, Naoto Sassa, Akira Yokomizo, Takashige Abe, Kazunari Tsuchihashi, Shuichi Tatarano, Junichi Inokuchi, Ryotaro Tomida, Maki Fujiwara, Atsushi Takahashi, Kazumasa Matsumoto, Kosuke Shimizu, Hiromasa Araki, Ryoma Kurahashi, Yu Osaki, Yu Tashiro, Masayuki Uegaki, Osamu Ogawa, Hiroshi Kitamura, Hiroyuki Nishiyama
Summary: The study found that despite comparable safety profiles, patients with PS >= 2 showed worse overall response rates and overall survival compared to those with PS <= 1. Among patients with impaired performance status, those with NLR <3.5 and no liver metastasis may benefit the most from pembrolizumab therapy.
Article
Urology & Nephrology
Minoru Kato, Takashi Kobayashi, Yoshiyuki Matsui, Katsuhiro Ito, Kensuke Hikami, Takeshi Yamada, Kosuke Ogawa, Kenji Nakamura, Naoto Sassa, Akira Yokomizo, Takashige Abe, Kazunari Tsuchihashi, Shuichi Tatarano, Junichi Inokuchi, Ryotaro Tomida, Maki Fujiwara, Atsushi Takahashi, Kazumasa Matsumoto, Kosuke Shimizu, Hiromasa Araki, Ryoma Kurahashi, Yu Ozaki, Yu Tashiro, Masayuki Uegaki, Takahiro Kojima, Junji Uchida, Osamu Ogawa, Hiroyuki Nishiyama, Hiroshi Kitamura
Summary: This study investigated the impact of chemotherapy cycles and response on overall survival in metastatic urothelial carcinoma patients treated with pembrolizumab. The results showed that the therapeutic benefit of pembrolizumab can be expected regardless of the response to or number of cycles of platinum-based first-line chemotherapy.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Meeting Abstract
Oncology
Akira Yokomizo, Futoshi Morokuma, Masatoshi Eto, Masaki Shiota, Hideyasu Matsuyama, Hiroaki Matsumoto, Toshiyuki Kamoto, Naoki Terada, Kazuya Kawahara, Hideki Enokida, Shuichi Tatarano, Naohiro Fujimoto, Katsuyoshi Higasijima, Hideki Sakai, Tomoaki Hakariya, Tsukasa Igawa, Shigetaka Suekane, Tomomi Kamba, Yutaka Sugiyama, Seiji Naito
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Shuichi Tatarano, Akihiko Mitsuke, Takashi Sakaguchi, Ryosuke Matsushita, Satoru Inoguchi, Hirofumi Yoshino, Hiroaki Nishimura, Yasutoshi Yamada, Hideki Enokida
Summary: This study analyzed the clinical outcomes of laparoscopic adrenalectomy for pheochromocytomas in hemodialysis compared with nonhemodialysis patients. The results showed that increasing intravascular volume before surgery in hemodialysis patients made perioperative hemodynamic management safer. The study also found that an increase in systolic blood pressure at CO2 insufflation was an independent predictor of a hypertensive spike during the surgery.
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hirofumi Yoshino, Shuichi Tatarano, Motoki Tamai, Masafumi Tsuruda, Sayaka Iizasa, Junya Arima, Issei Kawakami, Wataru Fukumoto, Ichiro Kawahara, Gang Li, Takashi Sakaguchi, Satoru Inoguchi, Yasutoshi Yamada, Hideki Enokida
Summary: Exosomes containing miR-1 were found to inhibit tumor growth in renal cell carcinoma (RCC), and the study explored the functional role of exosomal miR-1 and its potential as a tumor marker in RCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Masaki Shiota, Shuichi Tatarano, Toshiyuki Kamoto, Hideyasu Matsuyama, Hideki Sakai, Tsukasa Igawa, Tomomi Kamba, Naohiro Fujimoto, Yuya Sekine, Hiroko Kimura, Shintaro Narita, Naoki Terada, Yukihide Momozawa, Shusuke Akamatsu, Tomonori Habuchi, Akira Yokomizo, Seiji Naito, Masatoshi Eto
Summary: This study aimed to identify genetic markers that could predict the outcome of androgen-deprivation therapy (ADT) for advanced prostate cancer. Through a genome-wide association study (GWAS), single-nucleotide polymorphisms (SNPs) associated with radiographic progression-free survival (rPFS) and adverse events (AEs) were identified. Validation studies confirmed the association of these SNPs with ADT outcomes, and a genetic prognostic model using these SNPs showed excellent predictive efficacy for progression-free survival and overall survival. The study also revealed SNPs associated with AEs in ADT, such as de novo diabetes mellitus, arthralgia, and de novo dyslipidemia.
ENDOCRINE-RELATED CANCER
(2023)
Article
Urology & Nephrology
Shuichi Tatarano, Hideki Enokida, Masaya Yonemori, Rumiko Eura, Hirofumi Yoshino, Hiroaki Nishimura, Yasutoshi Yamada, Masayuki Nakagawa
Summary: The study found that the incidence of pre-DVT was 6.3% in patients undergoing urological surgery. Elderly patients and/or a cutoff D-dimer level of 1.8 μg/mL might be good indicators for pre-DVT screening by CUS. No patient developed symptomatic VTE during the 90-day postoperative follow-up period.
INVESTIGATIVE AND CLINICAL UROLOGY
(2021)
Correction
Oncology
Hideki Enokida, Yasutoshi Yamada, Shuichi Tatarano, Hirofumi Yoshino, Masaya Yonemori, Takashi Sakaguchi, Hiroaki Nishimura, Rumiko Eura, Masayuki Nakagawa
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)