Calcium-/Calmodulin-Dependent Protein Kinase II (CaMKII) Inhibition Induces Learning and Memory Impairment and Apoptosis

Cell death modulation by transient receptor potential melastatin channels TRPM2 and TRPM7 and their underlying molecular mechanisms

(2021) Ruixue Shi et al.   BIOCHEMICAL PHARMACOLOGY

Tilianin Ameliorates Cognitive Dysfunction and Neuronal Damage in Rats with Vascular Dementia via p-CaMKII/ERK/CREB and ox-CaMKII-Dependent MAPK/NF-κB Pathways

(2021) Hailun Jiang et al.   Oxidative Medicine and Cellular Longevity

BRAF mutation and its inhibitors in sarcoma treatment

(2020) Haotian Liu et al.   Cancer Medicine

Advances in Understanding CREB Signaling-Mediated Regulation of the Pathogenesis and Progression of Epilepsy

(2020) Guangming Wang et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1

(2020) Xuejiao Zhou et al.   Molecular Medicine Reports

The changes of serum zinc, copper, and selenium levels in epileptic patients: a systematic review and meta-analysis

(2020) Wanying Jia et al.   Expert Review of Clinical Pharmacology

Effects of ketogenic diet on cognitive function in pentylenetetrazol-kindled rats

(2020) Xueying Wang et al.   EPILEPSY RESEARCH

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

Histone demethylase PHF2 activates CREB and promotes memory consolidation

(2019) Hye‐Jin Kim et al.   EMBO REPORTS

Abnormal changes in voltage-gated sodium channels subtypes Na V 1.1, Na V 1.2, Na V 1.3, Na V 1.6 and CaM/CaMKII pathway in low-grade astrocytoma

(2018) Gefei Guan et al.   NEUROSCIENCE LETTERS

The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to NaV1.1

(2018) Jianing Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Calmodulin kinases: essential regulators in health and disease

(2017) Sayaka Takemoto-Kimura et al.   JOURNAL OF NEUROCHEMISTRY

Ischaemia- and excitotoxicity-induced CaMKII-Mediated neuronal cell death: The relative roles of CaMKII autophosphorylation at T286 and T253

(2017) John A.P. Rostas et al.   NEUROCHEMISTRY INTERNATIONAL

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

mTOR and MAPK: from localized translation control to epilepsy

(2016) Helena F. Pernice et al.   BMC NEUROSCIENCE

The Modulatory Effect of Metabotropic Glutamate Receptor Type-1α on Spike-Wave Discharges in WAG/Rij Rats

(2016) Fariba Karimzadeh et al.   MOLECULAR NEUROBIOLOGY

L-Ascorbate Protects Against Methamphetamine-Induced Neurotoxicity of Cortical Cells via Inhibiting Oxidative Stress, Autophagy, and Apoptosis

(2016) Ya-Ni Huang et al.   MOLECULAR NEUROBIOLOGY

Roles of NMDARs in maintenance of the mouse cerebrovascular endothelial cell-constructed tight junction barrier

(2016) Jui-Tai Chen et al.   TOXICOLOGY

Low-Mg2+ treatment increases sensitivity of voltage-gated Na+ channels to Ca2+/calmodulin-mediated modulation in cultured hippocampal neurons

(2015) Feng Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Continuous neurodegeneration and death pathway activation in neurons and glia in an experimental model of severe chronic epilepsy

(2015) Paola Nobili et al.   NEUROBIOLOGY OF DISEASE

Neonatal chlorpyrifos exposure induces loss of dopaminergic neurons in young adult rats

(2015) Jie Zhang et al.   TOXICOLOGY

Nonylphenol affects myocardial contractility and L-type Ca2+ channel currents in a non-monotonic manner via G protein-coupled receptor 30

(2015) Qinghua Gao et al.   TOXICOLOGY

Change of MicroRNA-134, CREB and p-CREB expression in epileptic rat

(2015) Yan Zhu et al.   Asian Pacific Journal of Tropical Medicine

A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis

(2015) Sylvia Ortega-Martínez   Frontiers in Molecular Neuroscience

Regulation of CaMKII signaling in cardiovascular disease

(2015) Mariya Y. Mollova et al.   Frontiers in Pharmacology

Grouping Pentylenetetrazol-Induced Epileptic Rats According to Memory Impairment and MicroRNA Expression Profiles in the Hippocampus

(2015) Xixia Liu et al.   PLoS One

The Ca2+-dependent interaction of calpastatin domain L with the C-terminal tail of the Cav1.2 channel

(2014) Wei Sun et al.   FEBS LETTERS

The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart

(2014) Dongxue Shao et al.   FEBS LETTERS

Inhibition of ERK1/2 signaling prevents epileptiform behavior in rats prone to audiogenic seizures

(2014) Margarita V. Glazova et al.   JOURNAL OF NEUROCHEMISTRY

NDEL1 was decreased in the CA3 region but increased in the hippocampal blood vessel network during the spontaneous seizure period after pilocarpine-induced status epilepticus

(2014) Q. Wu et al.   NEUROSCIENCE

Abnormal changes in voltage-gated sodium channels NaV1.1, NaV1.2, NaV1.3, NaV1.6 and in calmodulin/calmodulin-dependent protein kinase II, within the brains of spontaneously epileptic rats and tremor rats

(2013) Xiaoxue Xu et al.   BRAIN RESEARCH BULLETIN

Comparison between standard protocol and a novel window protocol for induction of pentylenetetrazol kindled seizures in the rat

(2013) Mahnaz Davoudi et al.   EPILEPSY RESEARCH

(−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75NTR Signaling in APP/PS1 Transgenic Mice

(2013) Mingyan Liu et al.   MOLECULAR NEUROBIOLOGY

Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy

(2013) Jan A. Gorter et al.   NEUROBIOLOGY OF DISEASE

The up-regulation of voltage-gated sodium channels subtypes coincides with an increased sodium current in hippocampal neuronal culture model

(2013) Feng Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Ca2+/Calmodulin-Dependent Protein Kinase II Contributes to Hypoxic Ischemic Cell Death in Neonatal Hippocampal Slice Cultures

(2013) Qing Lu et al.   PLoS One

Increasing levels of wild-type CREB up-regulates several activity-regulated inhibitor of death (AID) genes and promotes neuronal survival

(2012) Yan-Wei Tan et al.   BMC NEUROSCIENCE

CaMKII, MAPK, and CREB are coactivated in identified neurons in a neocortical circuit required for performing visual shape discriminations

(2012) Guo-Rong Zhang et al.   HIPPOCAMPUS

Role of signal transduction crosstalk between adenylyl cyclase and MAP kinase in hippocampus-dependent memory

(2012) Z. Xia et al.   LEARNING & MEMORY

Excitotoxic neuroprotection and vulnerability with CaMKII inhibition

(2011) Nicole M. Ashpole et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Gene expression and phosphoprotein profile of certain key neuronal signaling proteins following soman intoxication

(2011) G. RamaRao et al.   TOXICOLOGY

Hippocampal cell loss and propagation of abnormal discharges accompanied with the expression of tonic convulsion in the spontaneously epileptic rat

(2010) Ryosuke Hanaya et al.   BRAIN RESEARCH

Effective Post-insult Neuroprotection by a Novel Ca2+/ Calmodulin-dependent Protein Kinase II (CaMKII) Inhibitor

(2010) Rebekah S. Vest et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIα and cAMP-response element binding protein in the pentylenetetrazol-kindled rats

(2008) Pei Wang et al.   BRAIN RESEARCH

Selective blockade of CaMKII-α inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons

(2008) Dennis J. Goebel   BRAIN RESEARCH

Epileptogenesis causes an N-methyl-d-aspartate receptor/Ca2+-dependent decrease in Ca2+/calmodulin-dependent protein kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent epileptiform discharges

(2008) Robert E. Blair et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Voltage-gated sodium channel Nav1.1, Nav1.3 and β1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat

(2007) Feng Guo et al.   BRAIN RESEARCH BULLETIN