Article
Nutrition & Dietetics
Adam Darago, Michal Klimczak, Joanna Stragierowicz, Mateusz Jobczyk, Anna Kilanowicz
Summary: The concentrations of zinc, copper, and selenium in different parts of the prostate gland are associated with men's age and the nature of pathological changes. Zinc levels increase with age in the central part of the prostate, while lower zinc levels in the peripheral part may be linked to the development of prostate adenocarcinoma and benign prostatic hyperplasia. These results suggest a disruption in the homeostasis of essential elements in the etiology of BPH and PCa.
Article
Biochemistry & Molecular Biology
Cui-Ping Li, Yu-Xin Song, Zi-Jun Lin, Mei-Lin Ma, Lian-Ping He
Summary: This study explores the relationship between serum trace elements and lipid metabolism. It found no significant association between serum zinc and dyslipidemia, while other serum trace elements (iron, selenium, copper, chromium, and manganese) were associated with hyperlipidemia. The study suggests that zinc, copper, and calcium content in the human body may be related to lipid metabolism, but further research is needed.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Ophthalmology
Parul C. Gupta, Mona Pathak, Bhaskar Thakur, Rajesh Fogla, Aniruddha Agarwal, Jagat Ram
Summary: The aim of this study was to summarize and compare the levels of vitamin D and antioxidant trace elements in keratoconus (KC) patients and healthy controls. The results showed that KC patients had significantly lower serum levels of vitamin D, zinc, and selenium compared to the control group. The decrease in serum vitamin D level was greater in progressive patients compared to stable patients. Regular evaluation of these markers could be valuable in predicting disease progression and severity in KC patients.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hua Wang, Xian-Bao Li, Rong-Gui Huang, Nv-Wei Cao, Hong Wu, Kai-Di Li, Yi-Yu Wang, Bao-Zhu Li
Summary: This meta-analysis comprehensively assessed the levels of zinc, copper, iron, and selenium in systemic lupus erythematosus (SLE) patients and healthy controls. The results showed that SLE patients had lower levels of zinc and iron, higher levels of copper, and no significant difference in selenium compared to healthy controls. Further studies are needed to investigate the mechanisms of zinc, copper, and iron in SLE patients.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Nutrition & Dietetics
Branly Kilola Mbunga, Ingunn M. S. Engebretsen, Tor A. Strand, Elin L. F. Gjengdal, Pierre Z. Akilimali, Mina M. Langfjord, Pierrot L. Tugirimana, Mala Ali Mapatano
Summary: Prevalence of zinc and selenium deficiencies is high among children under five in Popokabaka, Democratic Republic of Congo. These deficiencies may be associated with inflammation and linear growth.
Article
Multidisciplinary Sciences
Sana Sadat Sajjadi, Sahar Foshati, Sajjad Haddadian-Khouzani, Mohammad Hossein Rouhani
Summary: The results of human studies on the relationship between selenium and depression are inconsistent. This systematic review and meta-analysis suggests that selenium may have a protective role against postpartum depression and can be considered as a beneficial adjuvant therapy in patients with depression. Further studies are needed to draw definitive conclusions.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Dong Huang, Shuming Zhong, Hong Yan, Shunkai Lai, Meifong Lam, Yanbin Jia
Summary: This study found that decreased serum zinc levels may increase susceptibility to suicidal ideation, but there is no significant relationship between serum copper or selenium levels and suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Kristina Lossow, Maria Schwarz, Anna P. Kipp
Summary: Cancer remains a major cause of death worldwide, and early diagnosis is critical for improved survival rates and treatment success. Studies have shown that cancer patients generally have elevated serum copper levels and diminished zinc levels, with inconsistent changes in selenium and iron levels depending on the type of cancer. Further research is needed to investigate whether these element concentrations can predict the survival probability of cancer patients.
Article
Nutrition & Dietetics
Vishwanath Pattan, Maria Mercedes Chang Villacreses, Rudruidee Karnchanasorn, Ken C. Chiu, Raynald Samoa
Summary: Trace elements like copper, selenium, and zinc play important roles in metabolism. A study in the representative U.S. population found that higher supplementation and serum concentrations of copper and selenium were associated with abnormal glucose metabolism. Therefore, caution is advised in supplementing copper, selenium, and zinc in non-deficient individuals.
Article
Nutrition & Dietetics
Hannah Wozniak, Christophe Le Terrier, Steve Primmaz, Noemie Suh, Sebastien Lenglet, Aurelien Thomas, Nicolas Vuilleumier, Sabrina Pagano, Aude de Watteville, Silvia Stringhini, Idris Guessous, Herve Quintard, Claudia Paula Heidegger, Jerome Pugin
Summary: The study compared the plasma levels of copper, selenium, and zinc in critically ill COVID-19 patients and less severe COVID-19 patients. It found that ICU patients had lower selenium and zinc levels and higher copper levels compared to hospitalized and non-hospitalized patients. Lower zinc levels were associated with more septic shock and increased mortality, while lower copper or selenium levels were associated with a longer time under mechanical ventilation. The data support the need for further studies on the potential benefits of zinc, copper, and selenium supplementation in severe COVID-19 patients.
Article
Cell Biology
John W. Steele, Ying Linda Lin, Nellie Chen, Bogdan J. Wlodarczyk, Qiuying Chen, Nabeel Attarwala, Madhu Venkatesalu, Robert M. Cabrera, Steven S. Gross, Richard H. Finnell
Summary: In conclusion, the adverse effects of VPA on pregnancy may be related to embryonic hypotaurine levels, and supplementation of hypotaurine may reduce VPA-induced NTDs. In the sensitive strain, administration of hypotaurine significantly reduced the occurrence of NTDs, while L-carnitine and coenzyme A reduced resorption rates but did not significantly affect NTD risk.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ruksar Sande, Gaurav Doshi, Angel Godad
Summary: Metals and non-metals can affect the normal functions of the central nervous system (CNS), leading to neurological conditions such as epilepsy. Different metals and non-metals have various effects on CNS, such as manganese acting as a cofactor for antioxidant enzymes, iron and zinc leading to the formation of reactive species, and copper blocking neuronal transmission. Utilizing the potential of metals and non-metals in epilepsy treatment can help develop new adjuvant therapies.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Amin Atazadegan, Motahar Heidari-Beni, Roya Riahi, Roya Kelishadi
Summary: The literature review found significant associations between selenium, zinc, and copper levels in maternal blood during pregnancy with birth weight, indicating that copper levels in SGA infants were higher than AGA infants.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shih-Yin Ho, Li Lin, I-Chun Chen, Che-Wen Tsai, Fang-Chia Chang, Horng-Huei Liou
Summary: The study evaluated the antiepileptic effect of the AMPA receptor antagonist perampanel (PER) on a mouse model of Dravet syndrome, showing significant therapeutic potential in reducing spontaneous recurrent seizures and improving hyperthermia-induced seizures. PER also demonstrated a synergistic effect in combination with stiripentol or valproic acid for attenuating heat-induced seizures, highlighting its potential as a treatment option for Dravet syndrome.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tingting Chen, Hongliang Zhang, Yang Zhang, Mengqi Yang, Juntao Wu, Minjun Yang, Jiangbo Lin, Weixu Gao, Lijiang Tang, Baohui Xu, Jianjun Jiang, Xiaofeng Chen
Summary: The meta-analysis found that circulating zinc and Zn/Cu ratio were significantly lower in AAA patients, and aneurysmal aorta associated with AAA also had significantly lower zinc levels and Zn/Cu ratio. However, there was no significant difference in circulating or aortic copper levels between AAA patients and the control group.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Cell Biology
Malwina Lisek, Joanna Stragierowicz, Feng Guo, Phillipp P. Prosseda, Magdalena Wiktorska, Bozena Ferenc, Anna Kilanowicz, Ludmila Zylinska, Tomasz Boczek
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Neurosciences
Tomasz Boczek, Qian Yu, Ying Zhu, Kimberly L. Dodge-Kafka, Jeffrey L. Goldberg, Michael S. Kapiloff
Summary: This study demonstrates that a neuronal perinuclear cAMP compartment is locally regulated by activity-dependent Ca2+ influx, providing local control for the enhancement of neurite extension.
Review
Biochemistry & Molecular Biology
Tomasz Boczek, Marta Sobolczyk, Joanna Mackiewicz, Malwina Lisek, Bozena Ferenc, Feng Guo, Ludmila Zylinska
Summary: Calcium plays crucial roles in mammalian neurons, with its concentration tightly regulated by calcium pumps to prevent detrimental consequences. These pumps not only transport calcium ions but also have tissue-specific functionalities and are regulated by calmodulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Waldemar Kryszkowski, Tomasz Boczek
Summary: Schizophrenia, a severe neuropsychiatric disease, is associated with disrupted glutamate neurotransmission, particularly involving ionotropic NMDA receptor hypofunction. Metabotropic glutamate receptors have emerged as crucial for cognitive and psychomotor function, with potential as molecular targets for novel antipsychotics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Tomasz Boczek, Joanna Mackiewicz, Marta Sobolczyk, Julia Wawrzyniak, Malwina Lisek, Bozena Ferenc, Feng Guo, Ludmila Zylinska
Summary: Schizophrenia is a common psychiatric illness characterized by psychosis episodes, with G protein-coupled receptors (GPCRs) playing a critical role in its development and treatment. Dysfunctions in neurotransmitter-GPCRs signaling likely underly the complex symptoms of schizophrenia, offering potential for new avenues in drug development.
Review
Pharmacology & Pharmacy
Ruixue Shi, Yu Fu, Dongyi Zhao, Tomasz Boczek, Wuyang Wang, Feng Guo
Summary: TRPM channels, important members of the TRP family, play crucial roles in cell physiology and cell death. Studies have shown their involvement in various cell death modalities, suggesting their potential as therapeutic targets in cell death-related diseases.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tomasz Boczek, Ludmila Zylinska
Summary: The activity of specific populations of neurons in different brain areas plays a critical role in decision-making processes related to synaptic transmission, adaptations to external signals, and the maintenance of neural function. The endocannabinoid system (ECS) is identified as a vital control system in the central nervous system (CNS), allowing for rapid responses to synaptic processes and inducing long-term changes. Endocannabinoids are bioactive lipid mediators that act primarily through two receptors, CB1R and CB2R, which can regulate downstream Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Malwina Lisek, Tomasz Boczek, Joanna Stragierowicz, Julia Wawrzyniak, Feng Guo, Michal Klimczak, Anna Kilanowicz, Ludmila Zylinska
Summary: PCN67 is considered the most toxic congener among polychlorinated naphthalenes, affecting human health by causing hepatotoxicity and disrupting reproductive, endocrine, and hematological systems. Studies have shown that PCN67 disturbs dopaminergic transmission by reducing dopamine synthesis, affecting the expression of antioxidant enzymes, and altering vesicular monoamine transporter 1 expression.
Article
Cell Biology
Jialu Wang, Xiaoxue Xu, Wanying Jia, Dongyi Zhao, Tomasz Boczek, Qinghua Gao, Qianhui Wang, Yu Fu, Miao He, Ruixue Shi, Xin Tong, Meixuan Li, Yu Tong, Dongyu Min, Wuyang Wang, Feng Guo
Summary: In this study, CaMKII inhibition was found to affect epileptogenesis by influencing CREB protein activity and activating the JNK signaling pathway, leading to learning and memory impairment and neuronal death.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Clinical Neurology
Mengmeng Wang, Xiaohong Zhang, Wanying Jia, Congcong Zhang, Tomasz Boczek, Meghan Harding, Yudan Liu, Ming Li, Shiqi Zhang, Shuai Lei, Dongfang Zhang, Feng Guo
Summary: The meta-analysis revealed significantly lower SOD levels in erythrocytes, serum, and plasma in patients with epilepsy compared to healthy controls, indicating potential oxidative damage. However, there was only a trend of decreased GSH-Px levels in erythrocytes of epilepsy patients without significant difference from healthy controls. This is the first meta-analysis examining circulating GSH-Px and SOD levels in patients with epilepsy and healthy controls.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Public, Environmental & Occupational Health
Lei Jiang, Huazhang Wu, Yang Song
Summary: This study aims to identify the key factors influencing the development of health tourism in China. The results show that the total health expenditure per capita and the number of domestic health consumers are the foremost factors affecting the health tourism trade. Additionally, China should diversify health tourism offerings for different consumer groups.
SOCIAL SCIENCE & MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ludmila Zylinska, Malwina Lisek, Feng Guo, Tomasz Boczek
Summary: Vitamin C is important for antioxidant defense and its deficiency in the nervous tissue can lead to disruptions in neurotransmission and brain function. Calcium plays a crucial role in neuronal processes and Vitamin C has a unique role in regulating calcium-involved pathways in the brain.
Review
Biochemistry & Molecular Biology
Malwina Lisek, Oskar Przybyszewski, Ludmila Zylinska, Feng Guo, Tomasz Boczek
Summary: The family of myocyte enhancer factor 2 (MEF2) transcription factors plays a crucial role in neuronal development and synaptic plasticity. MEF2s are involved in regulating the growth, pruning, and survival of neurons in the developing brain. They also impact learning and memory formation by controlling the number of synapses in the hippocampus. Dysfunctions in MEF2 activity have been linked to age-dependent neuronal dysfunctions and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Malwina Lisek, Ludmila Zylinska, Tomasz Boczek
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
