RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7

Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity

(2021) Rui Zhang et al.   SEMINARS IN CANCER BIOLOGY

YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy

(2020) Barry J. Thompson   BIOESSAYS

Progress in systemic therapy for triple-negative breast cancer

(2020) Hongnan Mo et al.   Frontiers of Medicine

Hippo Signaling in Embryogenesis and Development

(2020) Zhengming Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

YAP and TAZ Are Not Identical Twins

(2020) Francesca Reggiani et al.   TRENDS IN BIOCHEMICAL SCIENCES

Efficacy and safety of pembrolizumab based therapies in triple-negative breast cancer: A systematic review of clinical trials

(2020) Muhammad Ashar Ali et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

LIN28: A cancer stem cell promoter for immunotherapy in head and neck squamous cell carcinoma

(2019) Mengxue Li et al.   ORAL ONCOLOGY

Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28

(2018) Longfei Wang et al.   Cell Reports

H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance

(2017) Fei Peng et al.   Cell Death & Disease

LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation

(2017) Longfei Wang et al.   Cell Reports

The LIN28/let-7 Pathway in Cancer

(2017) Julien Balzeau et al.   Frontiers in Genetics

Hippo pathway and breast cancer stem cells

(2016) Marcello Maugeri-Saccà et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

(2016) Peng Li et al.   GENES & DEVELOPMENT

Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression

(2016) Yaxue Zeng et al.   MOLECULAR CELL

Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer

(2016) M-H Kang et al.   ONCOGENE

DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer

(2016) Y M Choi et al.   ONCOGENE

YAP and TAZ Take Center Stage in Cancer

(2015) Kun Zhang et al.   BIOCHEMISTRY

LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans

(2015) Ho-Chou Tu et al.   GENES & DEVELOPMENT

Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy

(2015) A Borah et al.   Oncogenesis

Lin28: Primal Regulator of Growth and Metabolism in Stem Cells

(2013) Ng Shyh-Chang et al.   Cell Stem Cell

LIN28/LIN28B: An emerging oncogenic driver in cancer stem cells

(2013) Jianbiao Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma

(2012) S. H. Beachy et al.   BLOOD

Lin28 regulates HER2 and promotes malignancy through multiple mechanisms

(2012) Chen Feng et al.   CELL CYCLE

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

(2012) Jan J Molenaar et al.   NATURE GENETICS

lin-28 Controls the Succession of Cell Fate Choices via Two Distinct Activities

(2012) Bhaskar Vadla et al.   PLoS Genetics

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes

(2011) J. Jin et al.   NUCLEIC ACIDS RESEARCH

LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms

(2011) C E King et al.   ONCOGENE

LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro

(2010) E. Balzer et al.   DEVELOPMENT

Epithelial Mesenchymal Transition Traits in Human Breast Cancer Cell Lines Parallel the CD44hi/CD24lo/- Stem Cell Phenotype in Human Breast Cancer

(2010) Tony Blick et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The CD44+/CD24− phenotype relates to ‘triple-negative’ state and unfavorable prognosis in breast cancer patients

(2010) Alexandra Giatromanolaki et al.   MEDICAL ONCOLOGY

Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer

(2010) S Peng et al.   ONCOGENE

Direct cell reprogramming is a stochastic process amenable to acceleration

(2009) Jacob Hanna et al.   NATURE

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells

(2009) Caihong Qiu et al.   NUCLEIC ACIDS RESEARCH

Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells

(2009) B. Xu et al.   RNA

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY