Repurposing Natural Dietary Flavonoids in the Modulation of Cancer Tumorigenesis: Decrypting the Molecular Targets of Naringenin, Hesperetin and Myricetin

Nitrogen-containing naringenin derivatives for reversing multidrug resistance in cancer

(2020) Ricardo J. Ferreira et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo

(2020) Bharat Pateliya et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interconnection between Metabolism and Cell Cycle in Cancer

(2019) Philippe Icard et al.   TRENDS IN BIOCHEMICAL SCIENCES

Apoptosis: A mammalian cell bioprocessing perspective

(2019) Antonio L. Grilo et al.   BIOTECHNOLOGY ADVANCES

Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2/ARE/glyoxalase 1 pathway

(2019) Ya-Jing Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma

(2019) Yadong Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Naringenin ameliorates progression of endometriosis by modulating Nrf2/Keap1/ HO1 axis and inducing apoptosis in rats

(2019) Radhika Kapoor et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hesperetin is a potent bioactivator that activates SIRT1-AMPK signaling pathway in HepG2 cells

(2019) Hajar Shokri Afra et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways

(2019) Zhenjiang Zhao et al.   INFLAMMOPHARMACOLOGY

Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways

(2019) Sun Hyo Jo et al.   ARCHIVES OF PHARMACAL RESEARCH

Protective effects of hesperetin on lipopolysaccharide-induced acute lung injury by targeting MD2

(2019) Jinyan Ye et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation

(2019) Qiang Li et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Akt in cancer: Mediator and more

(2019) Sundaramoorthy Revathidevi et al.   SEMINARS IN CANCER BIOLOGY

Flavonoids showed anticancer effects on the ovarian cancer cells: Involvement of reactive oxygen species, apoptosis, cell cycle and invasion

(2019) Zehra Tavsan et al.   BIOMEDICINE & PHARMACOTHERAPY

Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis

(2019) Xinliang Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Enhanced cellular cholesterol efflux by naringenin is mediated through inhibiting endoplasmic reticulum stress - ATF6 activity in macrophages

(2019) Xiaoting Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Naringenin-induced HO-1 ameliorates high glucose or free fatty acids-associated apoptosis via PI3K and JNK/Nrf2 pathways in human umbilical vein endothelial cells

(2019) Jian Feng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cellular demolition: Proteins as molecular players of programmed cell death

(2019) Yogesh Kumar Dhuriya et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Naringenin attenuates the progression of liver fibrosis via inactivation of hepatic stellate cells and profibrogenic pathways

(2019) Erika Hernández-Aquino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship

(2019) Xiaoqing Fan et al.   TOXICOLOGY IN VITRO

Inhibition of PP2A by hesperetin may contribute to Akt and ERK1/2 activation status in cortical neurons

(2018) David Vauzour et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chemopreventive effect of Myricetin, a natural occurring compound, on colonic chronic inflammation and inflammation-driven tumorigenesis in mice

(2018) Mei-Jia Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

The citrus flavonone hesperetin attenuates the nuclear translocation of aryl hydrocarbon receptor

(2018) Yan Qin Tan et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Myricetin enhances on apoptosis induced by serum deprivation in PC12 cells mediated by mitochondrial signaling pathway

(2018) Gongxun Tan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Flavonoids from Chinese bayberry leaves induced apoptosis and G1 cell cycle arrest via Erk pathway in ovarian cancer cells

(2018) Yu Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Natural Products for the Management and Prevention of Breast Cancer

(2018) Sarmistha Mitra et al.   Evidence-based Complementary and Alternative Medicine

Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide

(2018) Allison Knickle et al.   FOOD AND CHEMICAL TOXICOLOGY

Front Cover

(2018)   IEEE SENSORS JOURNAL

Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1

(2018) Zike Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Naringenin Ameliorates Radiation-Induced Lung Injury by Lowering IL-1βLevel

(2018) Chao Zhang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Combination of Asiatic Acid and Naringenin Modulates NK Cell Anti-cancer Immunity by Rebalancing Smad3/Smad7 Signaling

(2018) Guang-Yu Lian et al.   MOLECULAR THERAPY

Myricetin suppresses breast cancer metastasis through down-regulating the activity of matrix metalloproteinase (MMP)-2/9

(2018) Yingqian Ci et al.   PHYTOTHERAPY RESEARCH

The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β

(2018) Kenji W. Ruiz-Miyazawa et al.   Journal of Functional Foods

Two birds, one stone: hesperetin alleviates chemotherapy-induced diarrhea and potentiates tumor inhibition

(2018) Yaping Yu et al.   Oncotarget

TGF-β Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction

(2018) Robert Furler et al.   Cancers

The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction

(2018) Chen Ye et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Myricetin attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models

(2018) Wei Hou et al.   Future Medicinal Chemistry

Combinatorial anti-proliferative effects of tamoxifen and naringenin: The role of four estrogen receptor subtypes

(2018) Zhixiang Xu et al.   TOXICOLOGY

Naringenin Attenuated Prostate Cancer Invasion via Reversal of Epithelial–to–Mesenchymal Transition and Inhibited uPA Activity

(2018) KUEI-YANG HAN et al.   ANTICANCER RESEARCH

Suppression of Taxanes Cytotoxicity by Citrus Flavonoid Hesperetin in PPC-1 Human Prostate Cancer Cells

(2018) KATRIN SAK et al.   ANTICANCER RESEARCH

Naringenin inhibited migration and invasion of glioblastoma cells through multiple mechanisms

(2018) Yen-Yu Chen et al.   ENVIRONMENTAL TOXICOLOGY

Anticancer Activity of Natural Compounds from Plant and Marine Environment

(2018) Anna Lichota et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biotinylated naringenin intensified anticancer effect of gefitinib in urethane-induced lung cancer in rats: favourable modulation of apoptotic regulators and serum metabolomics

(2018) Poonam Parashar et al.   Artificial Cells Nanomedicine and Biotechnology

Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats

(2018) Tajdar Husain Khan et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Nanocrystalline solid dispersions (NSD) of hesperetin (HRN) for prevention of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in Sprague-Dawley (SD) rats

(2018) Sneha Sheokand et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Further enhanced dissolution and oral bioavailability of docetaxel by coamorphization with a natural P-gp inhibitor myricetin

(2018) Yuanfeng Wei et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Combined cereal and pulse flavonoids show enhanced bioavailability by downregulating phase II metabolism and ABC membrane transporter function in Caco-2 model

(2018) Shreeya Ravisankar et al.   FOOD CHEMISTRY

Enhanced oral bioavailability of docetaxel in rats combined with myricetin: In situ and in vivo evidences

(2017) Tianyun Hao et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Naringenin causes ASK1-induced apoptosis via reactive oxygen species in human pancreatic cancer cells

(2017) Hyun Jin Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Hesperetin induces an apoptosis-triggered extrinsic pathway and a p53- independent pathway in human lung cancer H522 cells

(2017) Ramesh Elango et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Naringenin-Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways

(2017) Whasun Lim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Naringenin Ameliorates Acute Inflammation by Regulating Intracellular Cytokine Degradation

(2017) Lingtao Jin et al.   JOURNAL OF IMMUNOLOGY

Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice

(2017) Samar M. Hassan et al.   PHARMACEUTICAL BIOLOGY

Naringenin suppresses growth of human placental choriocarcinoma via reactive oxygen species-mediated P38 and JNK MAPK pathways

(2017) Sunwoo Park et al.   PHYTOMEDICINE

Naringenin ameliorates LPS-induced acute lung injury through its anti-oxidative and anti-inflammatory activity and by inhibition of the PI3K/AKT pathway

(2017) Minghong Zhao et al.   Experimental and Therapeutic Medicine

Myricetin induces apoptosis and enhances chemosensitivity in ovarian cancer cells

(2017) Ai-Wen Zheng et al.   Oncology Letters

Molecular effects of hesperetin, a citrus flavanone on7,12-dimethylbenz(a)anthracene induced buccal pouch squamous cell carcinoma in golden Syrian hamsters

(2017) Sukumar Babukumar et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

MMP proteolytic activity regulates cancer invasiveness by modulating integrins

(2017) Alakesh Das et al.   Scientific Reports

Anti-inflammatory activity of myricetin fromDiospyros lotusthrough suppression of NF-κB and STAT1 activation and Nrf2-mediated HO-1 induction in lipopolysaccharide-stimulated RAW264.7 macrophages

(2016) Byoung Ok Cho et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Role of hesperetin in LDL-receptor expression in hepatoma HepG2 cells

(2016) Nora A. Bawazeer et al.   BMC Complementary and Alternative Medicine

Targeting Inflammation in Cancer Prevention and Therapy

(2016) J. Todoric et al.   Cancer Prevention Research

Flavonoid myricetin inhibits TNF-α-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-κB pathways in human keratinocytes

(2016) Da Hee Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFκB and PCNA expression

(2016) Lakshmi Narendra Bodduluru et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors

(2016) Bhavya Balan Chandrika et al.   LIFE SCIENCES

Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells

(2016) Nouha Nasr Bouzaiene et al.   LIFE SCIENCES

Naringenin-induced migration of embrynoic trophectoderm cells is mediated via PI3K/AKT and ERK1/2 MAPK signaling cascades

(2016) Whasun Lim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Myricetin induces apoptosis via endoplasmic reticulum stress and DNA double-strand breaks in human ovarian cancer cells

(2016) YE XU et al.   Molecular Medicine Reports

Myricetin suppresses p21-activated kinase 1 in human breast cancer MCF-7 cells through downstream signaling of the β-catenin pathway

(2016) DE JIAO et al.   ONCOLOGY REPORTS

Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway

(2016) Lei Bao et al.   TUMOR BIOLOGY

Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and −9

(2016) Huai-Lu Chang et al.   Experimental and Therapeutic Medicine

Myricetin: A Dietary Molecule with Diverse Biological Activities

(2016) Deepak Semwal et al.   Nutrients

Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APCMin/+ mice

(2016) Ye Li et al.   Oncotarget

Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice

(2015) Lakshmi Narendra Bodduluru et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

(2015) Hung-Rong Yen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hesperetin Induces the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species

(2015) Jixiang Zhang et al.   DIGESTIVE DISEASES AND SCIENCES

Implications of Akt2/Twist crosstalk on breast cancer metastatic outcome

(2015) Lucília Pereira et al.   DRUG DISCOVERY TODAY

Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway

(2015) HAIZHI HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway

(2015) Shreyasi Palit et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calcium

(2015) Jixiang Zhang et al.   MEDICAL ONCOLOGY

Myricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinoma

(2015) Soumya C. Iyer et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Fisetin and hesperetin induced apoptosis and cell cycle arrest in chronic myeloid leukemia cells accompanied by modulation of cellular signaling

(2015) Aysun Adan et al.   TUMOR BIOLOGY

The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks

(2015) Aysun Adan et al.   TUMOR BIOLOGY

Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species

(2015) Dandan Wu et al.   TUMOR BIOLOGY

Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis

(2015) Haizhi Huang et al.   Journal of Functional Foods

Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells

(2015) HAIYANG ZHANG et al.   Experimental and Therapeutic Medicine

Hesperetin Activates the Notch1 Signaling Cascade, Causes Apoptosis, and Induces Cellular Differentiation in Anaplastic Thyroid Cancer

(2014) Priyesh N. Patel et al.   ANNALS OF SURGICAL ONCOLOGY

Deconstructing breast cancer cell biology and the mechanisms of multidrug resistance

(2014) Mafalda Videira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Enhancement of recombinant myricetin on the radiosensitivity of lung cancer A549 and H1299 cells

(2014) Shijie Zhang et al.   Diagnostic Pathology

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Myricetin exerts anti-proliferative, anti-invasive, and pro-apoptotic effects on esophageal carcinoma EC9706 and KYSE30 cells via RSK2

(2014) Wenqiao Zang et al.   TUMOR BIOLOGY

Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells

(2012) Yong Yang et al.   CELL BIOCHEMISTRY AND FUNCTION

Antiproliferative Efficacy of Hesperetin (Citrus Flavanoid) in 1,2-Dimethylhydrazine-Induced Colon Cancer

(2012) Selvaraj Aranganathan et al.   PHYTOTHERAPY RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Myricetin Inhibits Akt Survival Signaling and Induces Bad-mediated Apoptosis in a Low Dose Ultraviolet (UV)-B-irradiated HaCaT Human Immortalized Keratinocytes

(2010) Wanyeon KIM et al.   JOURNAL OF RADIATION RESEARCH

Myricetin Suppresses Invasion and Migration of Human Lung Adenocarcinoma A549 Cells: Possible Mediation by Blocking the ERK Signaling Pathway

(2009) Yuan-Wei Shih et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY