Review
Cell Biology
Ruben Lopez-Bueno, Lars Louis Andersen, Ai Koyanagi, Rodrigo Nunez-Cortes, Joaquin Calatayud, Jose Casana, Borja Del Pozo Cruz
Summary: Handgrip strength is inversely associated with all-cause, cancer, and cardiovascular mortality risk, with varying dose-response relationships depending on the cause of mortality.
AGEING RESEARCH REVIEWS
(2022)
Article
Multidisciplinary Sciences
Laura Marie Hesselberg, Julie Nyholm Kyvsgaard, Jakob Stokholm, Hans Bisgaard, Klaus Bonnelykke, Bo Chawes
Summary: This study investigated the relationship between handgrip strength (HGS) and lung function metrics, as well as its role in diagnosing asthma. The results showed that HGS was positively associated with measures of forced flows, but not with airway resistance, reactivity, inflammation, or asthma status. However, HGS improved the accuracy of FEV1 estimation.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Laura Marie Hesselberg, Julie Nyholm Kyvsgaard, Jakob Stokholm, Hans Bisgaard, Klaus Bonnelykke, Bo Chawes
Summary: Studies have found an association between handgrip strength (HGS) and FEV1, but its importance in asthma pathophysiology and diagnosis is unclear. This study investigated the relationship between HGS and lung function metrics and its role in diagnosing asthma. The results showed that HGS is associated with forced flows, but not with airway resistance, reactivity, inflammation, or asthma status. However, HGS improves the accuracy of FEV1 estimation and further research is needed to explore its potential in asthma diagnostics.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Rayne de Almeida Marques, Vanusa Felicio de Souza, Thaina Cezini do Rosario, Maria Rita Pereira da Silva Garcia, Taisa Sabrina Silva Pereira, Jose Luiz Marques-Rocha, Valdete Regina Guandalini
Summary: This study analyzed the agreement between maximum and mean handgrip strength (HGS) measurements in identifying probable sarcopenia in cancer patients. The results showed a satisfactory agreement between maximum and mean HGS values, but individuals with probable sarcopenia were better identified through mean values.
Article
Medicine, General & Internal
Haofeng Zhou, Zepeng Chen, Yuting Liu, Yingxue Liao, Lan Guo, Mingyu Xu, Bingqing Bai, Fengyao Liu, Huan Ma, Xiaoxuan Yao, Qingshan Geng
Summary: This study used machine learning and data from the China Health and Retirement Longitudinal Study (CHARLS) to investigate the prognostic importance of handgrip strength (HGS) and establish sex-specific thresholds for health screening. The study found that HGS was a significant prognostic variable for all-cause mortality and improved prediction of a traditional office-based risk score.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nnamdi Mgbemena, Anne Jones, Pankaj Saxena, Nicholas Ang, Siva Senthuran, Anthony Leicht
Summary: The aim of this study was to investigate the acute changes in handgrip strength, lung function, and health-related quality of life (HRQoL) in adults undergoing elective cardiac surgery, as well as the relationships between these variables. The study found that undergoing cardiac surgery significantly reduced lung function, handgrip strength, and the physical component of HRQoL. Handgrip strength was a significant predictor of lung function pre-operatively, but not at physiotherapy discharge. Pre-operative lung function, HRQoL, and other variables were significant predictors of lung function and HRQoL during physiotherapy discharge.
Article
Multidisciplinary Sciences
Qing Li, Zhen Lin, Ye Hong, Yang Fu, Yueyun Chen, Ting Liu, Yue Zheng, Jiangfang Tian, Chunhua Liu, Wei Pu, Zhenyu Ding, Chun Wang
Summary: Patients with advanced non-small cell lung cancer are susceptible to brain metastases, including brain parenchymal metastases and leptomeningeal metastases. Patients with leptomeningeal metastases have a higher proportion of EGFR exon 21 point mutations and shorter survival compared to patients without brain metastases or with brain parenchymal metastases. Two prediction models were developed to predict the development of brain parenchymal metastases and leptomeningeal metastases in advanced non-small cell lung cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Jingsheng Cai, Fan Yang, Xun Wang
Summary: This study aims to investigate occult non-small cell lung cancer (NSCLC), an underappreciated tumor, and found that it is an aggressive tumor with poor prognosis. Surgery is the preferred treatment. More attention should be paid to this overlooked disease due to no evidence of tumor imaging.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Xiao-Ming Zhang, Zhi-Biao Zhang, Wei Chen, Xinjuan Wu
Summary: This study explores the association between handgrip strength and depression in cancer survivors, and finds a negative correlation between handgrip strength and depressive symptoms. Low handgrip strength is associated with an increased risk of depression in cancer survivors.
Article
Multidisciplinary Sciences
Olga-Cecilia Vargas-Pinilla, Eliana-Isabel Rodriguez-Grande
Summary: The study aimed to determine the reproducibility and level of agreement between handgrip dynamometry measurements in different positions. Results showed nearly perfect reproducibility in all positions, indicating that reliable results can be obtained as long as the standardization process is followed.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Bor-Shiuan Shyr, Chien-Sheng Huang, Hui-Shan Chen, Po-Kuei Hsu, Chao-Hua Chiu, Han-Shui Hsu, Chun-Ming Tsai, Yuh-Min Chen
Summary: This study aimed to investigate the impact of primary lung resection and systemic treatment on disease progression and survival in patients with oligometastatic NSCLC. The results showed no significant differences in perioperative complications, hospital length of stay, disease progression, overall death, median PFS, and OS between patients who received primary lung resection and systemic treatment. It was also found that patients with single-organ metastasis had significantly longer PFS and OS than those with oligometastases. Nonsolitary metastasis was identified as the only independent predictor of PFS.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Nasser Altorki, Xiaofei Wang, David Kozono, Colleen Watt, Rodney Landrenau, Dennis Wigle, Jeffrey Port, David R. Jones, Massimo Conti, Ahmad S. Ashrafi, Moishe Liberman, Kazuhiro Yasufuku, Stephen Yang, John D. Mitchell, Harvey Pass, Robert Keenan, Thomas Bauer, Daniel Miller, Leslie J. Kohman, Thomas E. Stinchcombe, Everett Vokes
Summary: This study compared lobectomy and sublobar resection in lung cancer patients. The results showed that in patients with tumors sized 2 cm or less and negative lymph nodes, sublobar resection was not inferior to lobectomy in terms of disease-free survival, and overall survival was similar between the two procedures.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Shawn J. Rice, Chandra P. Belani
Summary: Blood-based biomarkers, including systemic inflammation indicators and circulating factors, are associated with poor prognosis in lung cancer patients. Elevated levels of inflammation markers were found in non-small cell lung cancer (NSCLC) patients compared to small cell lung cancer (SCLC) and disease-free (DF) patients. Specific markers were identified as predictors of progression and overall survival in NSCLC patients, highlighting the potential for personalized treatment strategies.
Article
Oncology
Ambika S. Bhatt, Matthew B. Schabath, Aasha I. Hoogland, Heather S. L. Jim, Renee Brady-Nicholls
Summary: This study analyzed the dynamics of patient-reported outcomes (PROs) to predict tumor volume changes in non-small cell lung cancer patients undergoing immunotherapy. The study found significant correlations between changes in tumor volume over time and dizziness, insomnia, and fatigue. Cumulative changes in insomnia were able to predict progressive disease with 77% accuracy, an average of 45 days prior to the next imaging scan.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Pietro Rosellini, Samuel Amintas, Charline Caumont, Remi Veillon, Sigolene Galland-Girodet, Alain Cuguilliere, Laurent Nguyen, Charlotte Domblides, Amandine Gouverneur, Jean-Philippe Merlio, Julien Bezin, Pierre-Olivier Girodet
Summary: STK11 mutation is associated with poor prognosis in non-small cell lung cancer (NSCLC), leading to decreased response to immunotherapy treatment.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Nutrition & Dietetics
Zhenyu Huo, Feifei Chong, Liangyu Yin, Zongliang Lu, Jie Liu, Hongxia Xu
Summary: This study assessed the accuracy of the Global Leadership Initiative on Malnutrition (GLIM) criteria for diagnosing malnutrition through a meta-analysis. The results showed that the GLIM criteria have high diagnostic accuracy and the potential to be used as a gold standard for diagnosing malnutrition in clinical practice. Subgroup analysis also indicated better diagnostic value for the GLIM criteria compared to existing reference standards.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Xi Zhang, Qi Zhang, Meng Tang, Kang-Ping Zhang, Xiao-Wei Zhang, Meng-Meng Song, Guo-Tian Ruan, Qiang Sun, Wei Li, Hong-Xia Xu, Ming-Hua Cong, Li Deng, Han-Ping Shi
Summary: The nutrition-inflammation marker LCR is strongly associated with overall survival in overweight or obese cancer patients, providing additional prognostic information on top of ECOG-PS performance status.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Oncology
Jian Yin, Neal D. Freedman, Yiwei Liu, Sanford M. M. Dawsey, Huan Yang, Philip R. R. Taylor, Liangyu Yin, Bin Liu, Jianfeng Cui, Jinhu Fan, Wen Chen, Youlin Qiao, Christian C. C. Abnet
Summary: This study found that serum insulin and HOMA-IR may be risk factors for the development of primary liver cancer (PLC) or chronic liver disease (CLD) death. In HBV-positive patients, glucose was also associated with an increased risk of these diseases.
BRITISH JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Liangyu Yin, Feifei Chong, Zhenyu Huo, Na Li, Jie Liu, Hongxia Xu
Summary: This meta-analysis found a significant negative association between malnutrition defined by GLIM and overall survival in cancer patients based on analysis of 9 studies. However, due to the low quality of the source data, definitive conclusions cannot be made.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Letter
Biology
Liangyu Yin, Jie Liu, Ming Liu, Jin Zheng, Aiguo Xu, Quanjun Lyu, Yongdong Feng, Zengqing Guo, Hu Ma, Jipeng Li, Zhikang Chen, Hui Wang, Zengning Li, Chunling Zhou, Xi Gao, Min Weng, Qinghua Yao, Wei Li, Tao Li, Hanping Shi, Hongxia Xu
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Oncology
Zhenyu Huo, Feifei Chong, Liangyu Yin, Na Li, Mengyuan Zhang, Jing Guo, Xin Lin, Yang Fan, Ling Zhang, Hongmei Zhang, Muli Shi, Xiumei He, Zongliang Lu, Jie Liu, Wei Li, Hanping Shi, Hongxia Xu
Summary: This study developed an accurate and high-efficiency diagnostic system for cancer cachexia (CC), which can help clinicians and dieticians estimate the probability of cachexia in cancer patients.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Geriatrics & Gerontology
Liangyu Yin, Jiuwei Cui, Xin Lin, Long Li, Na Li, Yang Fan, Ling Zhang, Jie Liu, Feifei Chong, Zongliang Lu, Chang Wang, Tingting Liang, Xiangliang Liu, Li Deng, Mei Yang, Jiami Yu, Xiaojie Wang, Minghua Cong, Zengning Li, Min Weng, Qinghua Yao, Pingping Jia, Zengqing Guo, Wei Li, Chunhua Song, Hanping Shi, Hongxia Xu
Summary: This study evaluated the combined prognostic value of fat mass and nutritional status for mortality in patients with cancer cachexia. A new prognostic index, the triceps skinfold-albumin index (TA), was defined and evaluated. The TA showed better performance in predicting mortality and may improve the selection of intervention strategies to optimize the survival of patients with cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Immunology
Lihua Kang, Xiangliang Liu, Wei Ji, Kaiwen Zheng, Yuguang Li, Yanqiu Song, Hua He, Xiaomeng Wang, Tingting Yang, Meng Guan, Ge Zhu, Yangyang Gao, Yanjie Guan, Lei Wang, Wei Li
Summary: The study aims to clarify the role of neutrophil-to-lymphocyte ratio (NLR) in body functional status, nutritional risk, and nutritional status in cancer patients. A multi-center cross-sectional study was conducted, and the results showed that NLR significantly influenced body functions, nutritional risks, and nutritional status.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Nutrition & Dietetics
Lingyu Li, Wenqian Li, Dongsheng Xu, Hua He, Wang Yang, Hanfei Guo, Xiangliang Liu, Wei Ji, Chunhua Song, Hongxia Xu, Wei Li, Hanping Shi, Jiuwei Cui
Summary: This study investigated the impact of adipose tissue indicators on the prognosis of cancer patients and found that visceral fat area (VFA) is a more effective indicator associated with higher risk of mortality in various types of cancer.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Wei Ji, XiangLiang Liu, Pengfei Liu, YuWei He, YiXin Zhao, Kaiwen Zheng, JiuWei Cui, Wei Li
Summary: Research shows that reduced muscle mass is an indicator of malnutrition. By using the appendicular skeletal muscle mass index (ASMI) and fat-free mass index (FFMI), the presence of reduced muscle mass can be determined. These indicators have a significant impact in diagnosing severe malnutrition and predicting survival rates in cancer patients.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.
