Article
Environmental Sciences
Xiaoying Zhu, Wudi Hao, Ziyue Liu, Yushuai Song, Chenyu Hao, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Cuihong Jin
Summary: Aluminum exposure activates microglia and induces neuroinflammation through P2X7-NLRP3 pathway. P2X7 and HIF-1 alpha have a mutual regulatory relationship in the progression of neuroinflammation. BBG and YC-1 intervention can relieve the injuries caused by aluminum-induced neuroinflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Roberta Fusco, Rosalba Siracusa, Daniela Impellizzeri, Alessio Filippo Peritore, Enrico Gugliandolo, Livia Interdonato, Andrea Maria Sforza, Rosalia Crupi, Salvatore Cuzzocrea, Tiziana Genovese, Marika Cordaro, Rosanna Di Paola
Summary: Fibromyalgia is a chronic condition causing widespread pain and reduced quality of life. In this study, the inhibitor BBG showed positive effects in reducing pain and behavioral deficits in a rat model of fibromyalgia induced by reserpine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhihao Xu, Guoqing Zhang, Xiaoyue Zhang, Yu Lei, Yuliang Sun, Ya'nan He, Fen Yang, Wenbin Nan, Xuekun Xing, Yonghai Li, Juntang Lin
Summary: This study found that menstrual blood-derived endometrial stem cells can partially suppress neuroinflammatory reactions by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 signaling pathway. These findings could be very useful for the development of an alternative stem cell-based therapy for neuroinflammation-associated disorders.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Review
Immunology
Yunna Li, Yun Xia, Sijia Yin, Fang Wan, Junjie Hu, Liang Kou, Yadi Sun, Jiawei Wu, Qiulu Zhou, Jinsha Huang, Nian Xiong, Tao Wang
Summary: Recent studies have shown that the excessive activation of microglia and release of pro-inflammatory cytokines play crucial roles in the pathogenesis and progression of Parkinson's disease (PD). The elevated level of NLRP3 inflammasome in activated microglia in the substantia nigra of PD patients exacerbates the pathology and accelerates disease progression. Current therapeutic drugs for PD primarily focus on relieving clinical symptoms, as there are no established strategies to stop or reverse the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Duo Chen, Lu Sui, Cao Chen, Sanchuan Liu, Xianfeng Sun, Junhong Guan
Summary: Atorvastatin has therapeutic effects on patients with ICH by inhibiting the activities of glial cells and inflammasomes, protecting neurons from damage and preventing neurological deficits.
Article
Multidisciplinary Sciences
Dalia Zaafar, Heba M. A. Khalil, Rabab Ahmed Rasheed, Rania Farag A. Eltelbany, Sawsan A. A. Zaitone
Summary: This study investigated the protective effect of hesperetin against sorafenib-induced cardiotoxicity by modulating the NLRP3/TLR4 signaling pathway and apoptosis. The combination of hesperetin and sorafenib reduced inflammation and improved cardiac tissue damage. Clinical studies are needed to support the use of hesperetin as an adjuvant for mitigating sorafenib cardiotoxicity.
Article
Food Science & Technology
Wudi Hao, Chenyu Hao, Chengrong Wu, Yuqing Xu, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Cuihong Jin
Summary: Aluminum exposure can induce neuronal cell pyroptosis and neuroinflammation through the DDX3X-NLRP3 inflammasome signaling pathway, which can be alleviated by Rsv through activating SIRT1.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Wudi Hao, Xiaoying Zhu, Ziyue Liu, Yushuai Song, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Cuihong Jin
Summary: This study found that aluminum exposure can induce pyroptosis and neurotoxicity, causing adverse effects on the nervous system. DDX3X plays a role in determining cell survival or death by regulating the NLRP3 pyroptosis pathway or stress granules. Excessive activation of microglia may damage neurons and worsen nerve injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, Research & Experimental
Amany A. Alzokaky, Ahmed A. Al-Karmalawy, Mohamed A. Saleh, Walied Abdo, Amira E. Farage, Amany Belal, Mohammed A. S. Abourehab, Samar A. Antar
Summary: The study aims to investigate the preventive role of Metformin in DOX-induced cardiotoxicity. The results showed that Metformin reduced cardiac toxicity caused by DOX, possibly by inhibiting the HMGB1/NF-Kappa B inflammatory pathway and preserving heart function.
Review
Neurosciences
Qiu-Qin Han, Weidong Le
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopamine neurons and the formation of Lewy bodies. Alpha-synuclein and the NLRP3 inflammasome play crucial roles in neuroinflammation in PD. Understanding the molecular mechanisms and targeting strategies of the NLRP3 inflammasome may contribute to the development of effective therapies for PD.
NEUROSCIENCE BULLETIN
(2023)
Article
Pharmacology & Pharmacy
Ping Yu, Yuangeng Li, Wenwen Fu, Xin Li, Yanzhe Liu, Yaozhen Wang, Xiaofeng Yu, Huali Xu, Dayun Sui
Summary: Panax quinquefolius L. saponins (PQS) have shown potential in alleviating the symptoms of no-reflow (NR) by reducing inflammation in a myocardial ischemia/reperfusion (MI/R) model.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Xiao Tong, Li Chen, Shijun He, Shuangshuang Liu, Jiaying Yao, Zhenguang Shao, Yang Ye, Sheng Yao, Zemin Lin, Jianping Zuo
Summary: Philadelphia possesses significant anti-inflammatory properties and is expected to be a potential drug for UC treatment. Our study delves into the underlying mechanisms of Philadelphia therapy and highlights the potential for further research in developing Philadelphia-based treatments for UC.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Cell Biology
Shan-Shan Zhang, Man Liu, Dong-Ni Liu, Ying-Lin Yang, Guan-Hua Du, Yue-Hua Wang
Summary: TLR4-IN-C34 exhibits anti-neuroinflammatory activity through inhibition of the TLR4/MyD88/NF-κB/NLRP3 signaling pathway and reducing ROS production in BV2 cells stimulated by LPS.
Article
Behavioral Sciences
Yicong Wei, Yonghong Hu, Keming Qi, Ye Li, Jianxiong Chen, Ruiguo Wang
Summary: This study found that dihydromyricetin (DMY) can improve sickness and depressive-like behavior caused by neuroinflammation. It exerts its anti-depressive effects by suppressing the activation of the TLR4/Akt/HIF1a/NLRP3 signaling pathway.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Immunology
Adrianne F. Pike, Francesca Longhena, Gaia Faustini, Jean-Marc Van Eik, Iris Gombert, Maaike A. C. Herrebout, Mona M. H. E. Fayed, Michele Sandre, Tatiana Varanita, Charlotte E. Teunissen, Jeroen J. M. Hoozemans, Arianna Bellucci, Robert Veerhuis, Luigi Bubacco
Summary: This study reveals that dopamine inhibits the activation of NLRP3 inflammasome in primary human microglia, providing insights into the potential therapeutic target for Parkinson's disease.
JOURNAL OF NEUROINFLAMMATION
(2022)
