Metformin reduces neuroinflammation and improves cognitive functions after traumatic brain injury

Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury

(2020) Yunxiang Zhou et al.   Cell Communication and Signaling

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

(2020) Kevin A. Guttenplan et al.   Cell Reports

Crosstalk Between Astrocytes and Microglia: An Overview

(2020) Agata Matejuk et al.   Frontiers in Immunology

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury

(2019) Victoria L. DiBona et al.   Journal of Neuroinflammation

Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis

(2019) Lukas Muri et al.   Journal of Neuroinflammation

Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke

(2019) Rebecca M. Ruddy et al.   Science Advances

Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway

(2018) Li Tao et al.   BRAIN RESEARCH BULLETIN

Mild TBI and risk of Parkinson disease

(2018) Raquel C. Gardner et al.   NEUROLOGY

Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy

(2018) Khashayar Afshari et al.   SPINAL CORD

Metformin treatment ameliorates diabetes-associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1

(2018) Daisuke Tanokashira et al.   FEBS Open Bio

Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity

(2017) Qian Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mild Traumatic Brain Injury Produces Long-Lasting Deficits in Synaptic Plasticity in the Female Juvenile Hippocampus

(2017) Emily R. White et al.   JOURNAL OF NEUROTRAUMA

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Head Injury as a Risk Factor for Dementia and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of 32 Observational Studies

(2017) Yanjun Li et al.   PLoS One

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

Alterations of functional properties of hippocampal networks following repetitive closed-head injury

(2016) Omar C. Logue et al.   EXPERIMENTAL NEUROLOGY

Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome

(2016) Julia L. Hill et al.   JOURNAL OF NEUROCHEMISTRY

Do microglia play a role in sex differences in TBI?

(2016) Henry W. Caplan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Erratum: Corrigendum: Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats

(2016) Frank A Duca et al.   NATURE MEDICINE

Severity-Dependent Long-Term Spatial Learning-Memory Impairment in a Mouse Model of Traumatic Brain Injury

(2016) Chengrui An et al.   Translational Stroke Research

Traumatic brain injuries

(2016) Kaj Blennow et al.   Nature Reviews Disease Primers

MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism

(2015) Laura P. Bernard et al.   PLoS One

Repeated Mild Traumatic Brain Injury Causes Chronic Neuroinflammation, Changes in Hippocampal Synaptic Plasticity, and Associated Cognitive Deficits

(2014) Stephanie L Aungst et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Working memory capacity links cognitive reserve with long-term memory in moderate to severe TBI: a translational approach

(2014) Joshua Sandry et al.   JOURNAL OF NEUROLOGY

Burrowing and nest building behavior as indicators of well-being in mice

(2014) Paulin Jirkof   JOURNAL OF NEUROSCIENCE METHODS

Changing patterns in the epidemiology of traumatic brain injury

(2013) Bob Roozenbeek et al.   Nature Reviews Neurology

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

(2013) H. A. Hirsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation

(2012) Jing Wang et al.   Cell Stem Cell

The Polarity Protein Partitioning-defective 1 (PAR-1) Regulates Dendritic Spine Morphogenesis through Phosphorylating Postsynaptic Density Protein 95 (PSD-95)

(2012) Qian Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rate of Neurodegeneration in the Mouse Controlled Cortical Impact Model Is Influenced by Impactor Tip Shape: Implications for Mechanistic and Therapeutic Studies

(2011) Jennifer M. Pleasant et al.   JOURNAL OF NEUROTRAUMA

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Gender and the Injured Brain

(2009) Kamila Vagnerova et al.   ANESTHESIA AND ANALGESIA

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells

(2008) Zhonglin Xie et al.   CIRCULATION