IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice

TH17 Cell Induction and Effects of IL-17A and IL-17F Blockade in Experimental Colitis

(2013) Esben Gjerløff Wedebye Schmidt et al.   INFLAMMATORY BOWEL DISEASES

A Novel Role for IL-27 in Mediating the Survival of Activated Mouse CD4 T Lymphocytes

(2013) G. Kim et al.   JOURNAL OF IMMUNOLOGY

Type I IFNs Regulate Effector and Regulatory T Cell Accumulation and Anti-Inflammatory Cytokine Production during T Cell-Mediated Colitis

(2013) A. Kole et al.   JOURNAL OF IMMUNOLOGY

SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer

(2012) Yi Li et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology

(2012) Aisling O’Hara Hall et al.   IMMUNITY

Interleukin-27 Priming of T Cells Controls IL-17 Production In trans via Induction of the Ligand PD-L1

(2012) Kiyoshi Hirahara et al.   IMMUNITY

RETRACTED: Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization

(2012) Shaun Spence et al.   IMMUNITY

Human Primary Keratinocytes Show Restricted Ability to Up-regulate Suppressor of Cytokine Signaling (SOCS)3 Protein Compared with Autologous Macrophages

(2012) Jana Zeitvogel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Generation of Colitogenic Th17 CD4 T Cells Is Enhanced by IL-17+    T Cells

(2011) J.-s. Do et al.   JOURNAL OF IMMUNOLOGY

IL-27 Enhances LPS-Induced Proinflammatory Cytokine Production via Upregulation of TLR4 Expression and Signaling in Human Monocytes

(2011) C. Guzzo et al.   JOURNAL OF IMMUNOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

IL-27 promotes T cell–dependent colitis through multiple mechanisms

(2010) Jennifer H. Cox et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical Role of the IFN-Stimulated Gene Factor 3 Complex in TLR-Mediated IL-27p28 Gene Expression Revealing a Two-Step Activation Process

(2010) Céline Molle et al.   JOURNAL OF IMMUNOLOGY

A role for IL-27p28 as an antagonist of gp130-mediated signaling

(2010) Jason S Stumhofer et al.   NATURE IMMUNOLOGY

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

IL-27 Regulates Homeostasis of the Intestinal CD4+ Effector T Cell Pool and Limits Intestinal Inflammation in a Murine Model of Colitis

(2009) A. E. Troy et al.   JOURNAL OF IMMUNOLOGY

IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells

(2009) C. Diveu et al.   JOURNAL OF IMMUNOLOGY

Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) Marcin Imielinski et al.   NATURE GENETICS

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

Regulation of the class II and class I MHC pathways in human THP-1 monocytic cells by interleukin-27

(2008) Xiao Ming Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY