Article
Cell Biology
Peter Deak, Bradley Studnitzer, Trevor Ung, Rachel Steinhardt, Melody Swartz, Aaron Esser-Kahn
Summary: In this study, a distinctive subpopulation of dendritic cells (DCs) that respond to pathogen-associated molecular patterns (PAMPs) was isolated and characterized. These cells, known as first responders (FRs), show increased responses to PAMPs and play a role in facilitating adaptive immune responses. Furthermore, they can be selectively targeted by vaccines to modulate antibody and T cell responses in vivo.
Article
Biochemistry & Molecular Biology
Anne-Kathrin Knuth, Arnaud Huard, Zumer Naeem, Peter Rappl, Rebekka Bauer, Ana Carolina Mota, Tobias Schmid, Ingrid Fleming, Bernhard Bruene, Simone Fulda, Andreas Weigert
Summary: The interaction between apoptotic cells and macrophages can significantly affect macrophage proliferation, which may play a critical role in the efficient clearance and resolution of inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Arthur Mortha, Romain Remark, Diane Marie Del Valle, Ling-Shiang Chuang, Zhi Chai, Ines Alves, Catarina Azevedo, Joana Gaifem, Jerome Martin, Francesca Petralia, Kevin Tuballes, Vanessa Barcessat, Siu Ling Tai, Hsin-Hui Huang, Ilaria Laface, Yeray Arteaga Jerez, Gilles Boschetti, Nicole Villaverde, Mona D. Wang, Ujunwa M. Korie, Joseph Murray, Rok-Seon Choung, Takahiro Sato, Renee M. Laird, Scott Plevy, Adeeb Rahman, Joana Torres, Chad Porter, Mark S. Riddle, Ephraim Kenigsberg, Salome S. Pinho, Judy H. Cho, Miriam Merad, Jean-Frederic Colombel, Sacha Gnjatic
Summary: This study found that anti-granulocyte macrophage-colony stimulating factor autoantibodies (aGMAbs) can predict the diagnosis of complicated Crohn's disease (CD) long before the actual diagnosis. These antibodies recognize uniquely glycosylated epitopes, and their presence is associated with impaired immune balance and altered myeloid cell and innate lymphoid cell function.
Review
Immunology
Yingzi Chen, Fan Li, Mengqing Hua, Meng Liang, Chuanwang Song
Summary: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that induces the differentiation of bone marrow progenitor cells into granulocytes and macrophages. However, it is now known that GM-CSF has multiple origins and pleiotropic effects. GM-CSF activates JAK2 and induces nuclear signals through JAK-STAT, MAPK, PI3K, and other pathways. GM-CSF plays a crucial role in interstitial lung disease, allergic lung disease, alcoholic lung disease, and pulmonary infections caused by bacteria, fungi, and viruses. This article reviews the latest understanding of the relationship between GM-CSF and lung homeostasis and diseases, highlighting the broader functions of GM-CSF beyond its name suggests.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Torki Alothaimeen, Evan Trus, Sameh Basta, Katrina Gee
Summary: The study reveals differences in macrophage development and cytokine expression between M-CSF and GM-CSF cells after virus infection. While R848-induced cytokine expression is enhanced, signaling molecule activation is decreased in LCMV-infected macrophages. Interestingly, TLR7 expression is maintained at higher levels in M-CSF cells compared to GM-CSF.
JOURNAL OF GENERAL VIROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ruipeng Wang, Tiankang Guo, Junliang Li
Summary: Peritoneal adhesion (PA) is a fibrotic tissue that connects abdominal or visceral organs to the peritoneum, and its formation can lead to various clinical diseases. Damage to peritoneal mesothelial cells (PMCs) is believed to be one of the causes of PA. This review aims to understand the mechanism of action of PMCs in PA and provide a theoretical foundation for the treatment and prevention of PA.
Article
Multidisciplinary Sciences
Juan Pablo Arnoletti, Joseph Reza, Armando Rosales, Alberto Monreal, Na'im Fanaian, Suzanne Whisner, Milan Srivastava, Julia Rivera-Otero, Gongxin Yu, Otto Phanstiel, Deborah A. Altomare, Quang Tran, Sally A. Litherland
Summary: PDAC CTCs have the potential to influence myeloid differentiation and/or antigen presenting cell activation in the PDAC portal blood microenvironment. Disrupting the interactions between CTCs and M-FBs may be a potential target for reversing the immunosuppression supporting CTC survival in the portal blood.
Article
Cell Biology
Rebecca Herzog, Juan Manuel Sacnun, Guadalupe Gonzalez-Mateo, Maria Bartosova, Katarzyna Bialas, Anja Wagner, Markus Unterwurzacher, Isabel J. Sobieszek, Lisa Daniel-Fischer, Krisztina Rusai, Lucia Pascual-Anton, Klaus Kaczirek, Andreas Vychytil, Claus Peter Schmitt, Manuel Lopez-Cabrera, Seth L. Alper, Christoph Aufricht, Klaus Kratochwill
Summary: Adding lithium chloride to peritoneal dialysis fluid can improve mesothelial cell survival, reduce angiogenesis and fibrosis, and provide a translatable intervention to counteract peritoneal membrane deterioration during PD therapy. This study identified a potential therapeutic strategy in repurposing LiCl as a cytoprotective PDF additive to combat PD-induced mesothelial cytotoxicity.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Muhammad S. Alam, Shizuka Otsuka, Nathan Wong, Aamna Abbasi, Matthias M. Gaida, Yu Fan, Daoud Meerzaman, Jonathan D. Ashwell
Summary: The study revealed that TNF can induce the differentiation of mouse CD4(+) T cells into proinflammatory Th17 cells, mediated by the nondeath TNF receptor TNFR2, and also has an impact on the generation of proinflammatory Th1 cells. Additionally, TNFR2-deficient CD4(+) T cells showed lower pathogenicity in EAE and colitis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pediatrics
Fook-Choe Cheah, Pietro Presicce, Tian-Lee Tan, Brenna C. Carey, Suhas G. Kallapur
Summary: The study found that exposure to GM-CSF antenatally results in accumulation of immature macrophages in the fetal lung interstitium. Lack of GM-CSF did not eliminate but delayed the transitioning of interstitial macrophages. These results suggest that other perinatal factors may play a role in modulating the maturation of alveolar macrophages in the developing fetal lung.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Sara Fuentelsaz-Romero, Andrea Cuervo, Lizbeth Estrada-Capetillo, Raquel Celis, Raquel Garcia-Campos, Julio Ramirez, Sergi Sastre, Rafael Samaniego, Amaya Puig-Kroger, Juan D. Canete
Summary: GM-CSF plays a key role in macrophage polarization in different types of arthritis, with CD163(+) macrophages expressing pro-inflammatory markers in all groups. Macrophage density is higher in the early stages of RA and PsA compared to persistent UA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Chiara Bernardi, Gaetan Maurer, Tao Ye, Patricia Marchal, Bernard Jost, Manuela Wissler, Ulrich Maurer, Philippe Kastner, Susan Chan, Celine Charvet
Summary: The transcription factor Ikaros regulates gene expression and chromatin accessibility in T cells to suppress the expression of pathogenic genes, particularly GM-CSF. This mechanism plays a critical role in preventing excessive GM-CSF expression in T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Tarani Kanta Barman, Amit K. Singh, Jesse L. Bonin, Tanvir Noor Nafiz, Sharon L. Salmon, Dennis W. Metzger
Summary: This study found that coinfection of SARS-CoV-2 and Streptococcus pneumoniae leads to lung inflammation and death, and the treatment methods differ. Treatment with murine GM-CSF can reduce bacteria and pathology, partially protecting from death, but therapeutic targeting of IFNs does not work. Combined vaccination provides 100% protection against subsequent coinfection.
Article
Immunology
Tatsuma Honzawa, Kazuhiko Matsuo, Shunya Hosokawa, Mayu Kamimura, Yuichiro Kaibori, Yuta Hara, Daisuke Nagakubo, Naoki Oiso, Akira Kawada, Atsushi Otsuka, Osamu Yoshie, Takashi Nakayama
Summary: This study investigated the role of CCR4 in collagen-induced arthritis (CIA) and found that CCR4 plays a critical role in the pathogenesis of CIA and may represent a new therapeutic target for rheumatoid arthritis (RA).
INTERNATIONAL IMMUNOLOGY
(2022)
Article
Oncology
Pingping Wang, Liqing Tao, Yudu Yu, Qiong Wang, Peihong Ye, Yi Sun, Jingping Zhou
Summary: This study aimed to investigate whether the JAK2/STAT3 pathway regulates PD-L1 expression in tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC), which can help us achieve further understanding of immune escape mechanisms in OSCC. The results showed that GM-CSF in tumor-conditioned medium from OSCC cells increased PD-L1 expression in TAMs through JAK2/STAT3 signaling pathway.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Anatomy & Morphology
Orsolya Kantor, Zsigmond Benko, Anna Enzsoly, Csaba David, Angela Naumann, Roland Nitschke, Arnold Szabo, Emese Palfi, Jozsef Orban, Miklos Nyitrai, Janos Nemeth, Agoston Szel, Akos Lukats, Bela Volgyi
BRAIN STRUCTURE & FUNCTION
(2016)
Article
Cell Biology
Petra Balogh, Arnold Szabo, Istvan Liko, Attila Patocs, Anna L. Kiss
CELL AND TISSUE RESEARCH
(2015)
Article
Cell Biology
Petra Balogh, Marton Magyar, Arnold Szabo, Nandor Muellner, Istvan Liko, Attila Patocs, Anna L. Kiss
EUROPEAN JOURNAL OF CELL BIOLOGY
(2015)
Article
Cell Biology
Orsolya Kantor, Szilvia Mezey, Jennifer Adeghate, Angela Naumann, Roland Nitschke, Anna Enzsoly, Arnold Szabo, Akos Lukats, Janos Nemeth, Zoltan Somogyvari, Bela Volgyi
CELL AND TISSUE RESEARCH
(2016)
Article
Neurosciences
Keisuke Yonehara, Michele Fiscella, Antonia Drinnenberg, Federico Esposti, Stuart Trenholm, Jacek Krol, Felix Franke, Brigitte Gross Scherf, Akos Kusnyerik, Jan Mueller, Arnold Szabo, Josephine Juettner, Francisco Cordoba, Ashrithpal Police Reddy, Janos Nemeth, Zoltan Zsolt Nagy, Francis Munier, Andreas Hierlemann, Botond Roska
Article
Multidisciplinary Sciences
Klaudia Szabo, Anna Enzsoly, Bulcsu Dekany, Arnold Szabo, Rozina I. Hajdu, Tamas Radovits, Csaba Matyas, Attila Olah, Lenke K. Laurik, Gabor M. Somfai, Bela Merkely, Agoston Szel, Akos Lukats
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Josephine Juttner, Arnold Szabo, Brigitte Gross-Scherf, Rei K. Morikawa, Santiago B. Rompani, Peter Hantz, Tamas Szikra, Federico Esposti, Cameron S. Cowan, Arjun Bharioke, Claudia P. Patino-Alvarez, Ozkan Keles, Akos Kusnyerik, Thierry Azoulay, Dominik Hartl, Arnaud R. Krebs, Dirk Schubeler, Rozina I. Hajdu, Akos Lukats, Janos Nemeth, Zoltan Z. Nagy, Kun-Chao Wu, Rong-Han Wu, Lue Xiang, Xiao-Long Fang, Zi-Bing Jin, David Goldblum, Pascal W. Hasler, Hendrik P. N. Scholl, Jacek Krol, Botond Roska
NATURE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Rozina Hajdu, Lenke K. Laurik, Klaudia Szabo, Bulcsu Dekany, Zsuzsanna Almasi, Anna Enzsoly, Arnold Szabo, Tunas Radovits, Csaba Matyas, Attila Olah, Agoston Szel, Gabor M. Somfai, Csaba David, Akos Lukats
SCIENTIFIC REPORTS
(2019)
Article
Rehabilitation
Julia Szita, Laszlo Kiss, Adam Biczo, Katalin Feher, Peter P. Varga, Aron Lazary
Summary: The STarT Back Tool is developed to identify modifiable prognostic factors for non-specific low back pain and classify patients into low, medium, and high risk of chronicity. The Hungarian version of the STarT Back Tool showed good reliability and validity in identifying risk groups of chronicity for low back pain patients. It can also be used to predict global treatment outcome in patients receiving group physical therapy.
DISABILITY AND REHABILITATION
(2022)
Article
Multidisciplinary Sciences
Dasha Nelidova, Rei K. Morikawa, Cameron S. Cowan, Zoltan Raics, David Goldblum, Hendrik P. N. Scholl, Tamas Szikra, Arnold Szabo, Daniel Hillier, Botond Roska
Article
Biochemistry & Molecular Biology
Cameron S. Cowan, Magdalena Renner, Martina De Gennaro, Brigitte Gross-Scherf, David Goldblum, Yanyan Hou, Martin Munz, Tiago M. Rodrigues, Jacek Krol, Tamas Szikra, Rachel Cuttat, Annick Waldt, Panagiotis Papasaikas, Roland Diggelmann, Claudia P. Patino-Alvarez, Patricia Galliker, Stefan E. Spirig, Dinko Pavlinic, Nadine Gerber-Hollbach, Sven Schuierer, Aldin Srdanovic, Marton Balogh, Riccardo Panero, Akos Kusnyerik, Arnold Szabo, Michael B. Stadler, Selim Orgul, Simone Picelli, Pascal W. Hasler, Andreas Hierlemann, Hendrik P. N. Scholl, Guglielmo Roma, Florian Nigsch, Botond Roska
Article
Anatomy & Morphology
Orsolya Kantor, Alexandra Varga, Roland Nitschke, Angela Naumann, Anna Enzsoely, Akos Lukats, Arnold Szabo, Janos Nemeth, Bela Voelgyi
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Cell Biology
Anna Enzsoely, Arnold Szabo, Klaudia Szabo, Agoston Szel, Janos Nemeth, Akos Lukats
HISTOLOGY AND HISTOPATHOLOGY
(2015)