Recent Advances in Aptamers Targeting Immune System

Ensemble and single-molecule biophysical characterization of D17.4 DNA aptamer–IgE interactions

(2016) Mohan-Vivekanandan Poongavanam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A time-resolved luminescent competitive assay to detect L-selectin using aptamers as recognition elements

(2015) Piotr J. Cywiński et al.   ANALYTICA CHIMICA ACTA

Modern affinity reagents: Recombinant antibodies and aptamers

(2015) Katherine Groff et al.   BIOTECHNOLOGY ADVANCES

An Act of Balance Between Adaptive and Maladaptive Immunity in Depression: a Role for T Lymphocytes

(2015) Catherine Toben et al.   Journal of Neuroimmune Pharmacology

Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications

(2015) Ken-ichiro Matsunaga et al.   Scientific Reports

The Role of Chemokines in Shaping the Balance Between CD4+ T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases

(2015) Nathan Karin et al.   Frontiers in Immunology

Subverting Toll-Like Receptor Signaling by Bacterial Pathogens

(2015) Victoria A. McGuire et al.   Frontiers in Immunology

Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides

(2015) Mulu Wu et al.   Acta Pharmaceutica Sinica B

Identification and Characterization of an Agonistic Aptamer Against the T Cell Costimulatory Receptor, OX40

(2015) Elizabeth D. Pratico et al.   Nucleic Acid Therapeutics

Detecting Transforming Growth Factor-β Release from Liver Cells Using an Aptasensor Integrated with Microfluidics

(2014) Zimple Matharu et al.   ANALYTICAL CHEMISTRY

Cellular Adhesion and the Endothelium

(2014) Abdullah Kutlar et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Aptamers in immunological research

(2014) Roald Nezlin   IMMUNOLOGY LETTERS

Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor

(2014) Shashi Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

(2014) Andreas Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct Roles of the Anaphylatoxins C3a and C5a in Dendritic Cell–Mediated Allergic Asthma

(2014) Carsten Engelke et al.   JOURNAL OF IMMUNOLOGY

The Role of TGF-β2 and Bone Morphogenetic Proteins in the Trabecular Meshwork and Glaucoma

(2014) Robert J. Wordinger et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

DNA Aptamers against Exon v10 of CD44 Inhibit Breast Cancer Cell Migration

(2014) Joji Iida et al.   PLoS One

Selection of a Novel DNA Aptamer for Assay of Intracellular Interferon-Gamma

(2014) Beibei Cao et al.   PLoS One

The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer Immunotherapy

(2014) Joanne Leung et al.   Immune Network

Toll-Like Receptors’ Pathway Disturbances are Associated with Increased Susceptibility to Infections in Humans

(2013) Josias Brito Frazão et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8

(2013) Ho Jin Sung et al.   BIOMATERIALS

Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agents

(2013) Maria Laura Belladonna et al.   Biotechnology & Genetic Engineering Reviews

Use of Oligonucleotide Aptamer Ligands to Modulate the Function of Immune Receptors

(2013) E. Gilboa et al.   CLINICAL CANCER RESEARCH

Targeting CD28 to prevent transplant rejection

(2013) Melissa Y Yeung et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Target replacement strategy for selection of DNA aptamers against the Fc region of mouse IgG

(2013) Jun Ma et al.   GENETICS AND MOLECULAR RESEARCH

Aptamers: multifunctional molecules for biomedical research

(2013) Jayeeta Banerjee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A Novel C5a-neutralizing Mirror-image (l-)Aptamer Prevents Organ Failure and Improves Survival in Experimental Sepsis

(2013) Kai Hoehlig et al.   MOLECULAR THERAPY

Targeting co-stimulatory pathways: transplantation and autoimmunity

(2013) Mandy L. Ford et al.   Nature Reviews Nephrology

Potential Capacity of Aptamers to Trigger Immune Activation in Human Blood

(2013) Meltem Avci-Adali et al.   PLoS One

Update on current and future novel therapies for dry age-related macular degeneration

(2013) Ella Leung et al.   Expert Review of Clinical Pharmacology

CD28 Aptamers as Powerful Immune Response Modulators

(2013) Fernando Pastor et al.   Molecular Therapy-Nucleic Acids

Simultaneous detection of cell-secreted TNF-α and IFN-γ using micropatterned aptamer-modified electrodes

(2012) Ying Liu et al.   BIOMATERIALS

Therapeutic RNA aptamers in clinical trials

(2012) Padma Sundaram et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing

(2012) Alexey Berezhnoy et al.   MOLECULAR THERAPY

Metastatic Cells Can Escape the Proapoptotic Effects of TNF-  through Increased Autocrine IL-6/STAT3 Signaling

(2011) S. Li et al.   CANCER RESEARCH

Roles for microRNAs in the regulation of cell adhesion molecules

(2011) S. Valastyan et al.   JOURNAL OF CELL SCIENCE

Randomized Phase III Trial of Paclitaxel/Carboplatin With or Without PF-3512676 (Toll-Like Receptor 9 Agonist) As First-Line Treatment for Advanced Non–Small-Cell Lung Cancer

(2011) Vera Hirsh et al.   JOURNAL OF CLINICAL ONCOLOGY

Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 Inhibition

(2011) Jiehua Zhou et al.   METHODS

Activation of the Alternative NFκB Pathway Improves Disease Symptoms in a Model of Sjogren's Syndrome

(2011) Adi Gilboa-Geffen et al.   PLoS One

RNA Aptamer Therapy for Vaso-Occlusion in Sickle Cell Disease

(2011) Angela D. Burnette et al.   Nucleic Acid Therapeutics

Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells

(2010) Hui Ying Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Is Interleukin-6 Receptor Blockade the Holy Grail for Inflammatory Diseases?

(2010) M A Febbraio et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Conformational plasticity of RNA for target recognition as revealed by the 2.15 Å crystal structure of a human IgG–aptamer complex

(2010) Yusuke Nomura et al.   NUCLEIC ACIDS RESEARCH

A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia

(2010) Prabodhika R. Mallikaratchy et al.   NUCLEIC ACIDS RESEARCH

Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses

(2009) Yi-Chung Chang et al.   FASEB JOURNAL

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Crystallization and preliminary X-ray diffraction studies of an RNA aptamer in complex with the human IgG Fc fragment

(2008) Shigeru Sugiyama et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Rabbit antibody detection with RNA aptamers

(2008) Yoshihito Yoshida et al.   ANALYTICAL BIOCHEMISTRY

Enrichment of Cell‐Targeting and Population‐Specific Aptamers by Fluorescence‐Activated Cell Sorting

(2008) Marie‐Sophie L. Raddatz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combinatorial selection of a single stranded DNA thioaptamer targeting TGF-β1 protein

(2008) Jonghoon Kang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

(2008) Claudia M. Dollins et al.   CHEMISTRY & BIOLOGY

Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G

(2008) S. Miyakawa et al.   RNA